Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models

Cortés, Alba; Clare, Simon; Costain, Alice; Almeida, Alexandre; McCarthy, Catherine; Harcourt, Katherine; Brandt, Cordelia; Tolley, Charlotte; Rooney, James; Berriman, Matthew; Lawley, Trevor D.; MacDonald, Andrew S.; Rinaldi, Gabriel; Cantacessi, Cinzia

doi:10.3389/fimmu.2020.593838

Cited by 31 publications

(81 citation statements)

References 70 publications

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“…Lactobacillus). This disruption in the gut microbiota was directly associated with higher worm and egg burden, together with amplified immune responses to Schistosoma antigens [84] . Interestingly, higher abundance of Fusobacterium spp.…”

Section: Escherichia Coli Live Bacteria Protects E Histolytica Against Oxidation By Two Patterns Of Mechanismsmentioning

confidence: 99%

Conceptions in parasite-microbiota relationships

Elsaftawy

Wassef

2021

Parasitologists United Journal

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Intracellular parasites(1) Toxoplasma gondii is an intracellular sporozoa that can cause infection in any nucleated cell. Toxoplasmosis has been shown to induce massive necrosis and extensive pathology in the distal intestinal mucosa and villi in murine models. These pathological changes were attributed to bacterial dysbiosis besides immune factors such as the CD-4 T cells and interferon gamma (IFN-γ) cytokine [15] . Dysbiosis had been proposed to be dependent on the destabilization of the intestinal barrier either by the lytic replication of the parasite or from the toxic by-products of the host immune reactions, such as nitrogen intermediates or reactive oxygen species. For instance, production of IFN-γ during toxoplasmosis leads to loss of Paneth cells resulting in reduced levels of the antimicrobial peptides and dysbiosis [16,17] dominated chiefly by Enterobacteriaceae [14] . In fact, the induced IFN-γ/ signal transducer and activator of transcription-1/ inducible nitric oxide synthase (IFN-γ/STAT-1/i-NOS) axis, was described as crucial for parasite resistance [18] . It was assumed to provide a pool of nitrate that acts as a source for anaerobic respiration and promotes overgrowth of Enterobacteriaceae.Similarly, in experimentally induced colitis using dextran sulphate sodium (DSS), host-derived nitrate was found to directly promote the flush of Enterobacteriaceae bacteria in the colon [19] . This proves that local inflammation in the large intestine causes upgrade of the respiratory electron acceptors

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Section: Escherichia Coli Live Bacteria Protects E Histolytica Against Oxidation By Two Patterns Of Mechanismsmentioning

confidence: 99%

Conceptions in parasite-microbiota relationships

Elsaftawy

Wassef

2021

Parasitologists United Journal

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“…Besides the risk factors mentioned above, infections with schistosomes disturb the host microbiota leading to intestinal dysbiosis before oviposition ( Jenkins et al, 2018 ). In addition, the original composition of host microbiota might affect the susceptibility to schistosome infection ( Córtes et al., 2020 ). In the context of UGS-bladder cancer, the urinary microbiome might be relevant for biomarker discovery to advance novel diagnostics and treatment ( Adebayo et al., 2017 ).…”

Section: Chemical Carcinogenesis May Be Responsible For Helminth Indumentioning

confidence: 99%

Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview

Costa

Gouveia

Rinaldi

et al. 2021

Front. Cell. Infect. Microbiol.

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Helminthiases are extremely prevalent in the developing world. In addition, the chronic infection with some parasitic worms are classified as carcinogenic. Therefore, it is utmost importance to understand the parasite-host interactions, the mechanisms underlay carcinogenesis and how they could be counteracted. This knowledge may ultimately guide novel control strategies that include chemotherapy-based approaches targeting these pathogens and associated pathologies caused by their infections. Little is known on how some helminthiases are associated with cancer; however, it has been hypothesized that chemical carcinogenesis may be involved in the process. Here, we summarize the current knowledge on chemical carcinogenesis associated with helminthiases, along with available therapeutic options and potential therapeutic alternatives including chemotherapy and/or immunotherapy. Ideally, the treatment of the carcinogenic helminthiases should target both the parasite and associated pathologies. The success of any chemotherapeutic regimen often depends on the host immune response during the infection and nutritional status among other factors. The close association between chemotherapy and cell-mediated immunity suggests that a dual therapeutic approach would be advantageous. In addition, there is a pressing need for complementary drugs that antagonize the carcinogenesis process associated with the helminth infections.

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Section: Parasites and Gut Microbiota Profilingmentioning

confidence: 99%

“…Experiments leaded in murine models of intestinal schistosomiasis have suggested the interactions between Schistosoma parasites and the host gut microbiota with a direct impact on the intestinal microbial communities [58]. In a study of Alba Cortés et al the gut microbiome composition of the host actually influenced the host susceptibility to S. mansoni infection, as well as infection-associated changes in gut microbiota profiles [58]. Some studies have evidenced that Necator americanus infection could alleviate chronic inflammation in celiac disease and improve prokaryotic species richness, reestablishing the eubiosis and immune homeostasis [59].…”

Section: Parasites and Gut Microbiota Profilingmentioning

confidence: 99%

Biome Profiling and Clinical Parasitology: Tools for Gut Microbiota Restoring

Pane¹,

Ristori²,

Gardini³

et al. 2021

Preprint

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A growing body of evidences is showing that dysbiotic gut microbiota may correlate with a wide range of disorders; hence, the clinical use of microbiota maps and fecal microbiota transplantation (FMT) can be exploited in the clinic of some infectious diseases. Through direct or indirect ecological and functional competition, FMT may stimulate decolonization of pathogens or opportunistic pathogens, modulating immune response and colonic inflammation, and restoring intestinal homeostasis, with reduction of host damage. Herein, we discuss how diagnostic parasitology may contribute to design clinical metagenomics pipelines and FMT programs, especially in pediatric subjects. The consequences of a more specialized diagnostics in the context of gut microbiota communities may improve the clinical parasitology and extend its applications to the prevention and treatment of several communicable and even noncommunicable disorders.

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Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models

Cited by 31 publications

References 70 publications

Conceptions in parasite-microbiota relationships

Conceptions in parasite-microbiota relationships

Control Strategies for Carcinogenic-Associated Helminthiases: An Integrated Overview

Biome Profiling and Clinical Parasitology: Tools for Gut Microbiota Restoring

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