Baseline serum exosome‐derived miRNAs predict HBeAg seroconversion in chronic hepatitis B patients treated with peginterferon

Hu, Qiankun; Wang, Qianqian; Zhang, Yi; Tao, Shuai; Zhang, Xueyun; Liu, Xiaoqin; Li, Xinyan; Jiang, Xuhua; Huang, Chenlu; Xu, Wei; Qi, Xun; Chen, Liang; Li, Qiang; Huang, Yuxian

doi:10.1002/jmv.26916

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…Exosomes contribute to the life cycle of hepatitis viruses, including replication, transition, and pathogenesis. 99 Hepatitis viruses (HBV 100,101 and HCV 102,103 ) efficiently transfer bioactive components utilizing the exosome pathway from infected cells to naïve cells. Additionally, hepatitis B virus e antigen was demonstrated to induce the activation of HSCs.…”

Section: Chronic Viral Hepatitismentioning

confidence: 99%

Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases

Yin¹,

Li²,

Song³

et al. 2022

J Clin Transl Hepatol

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Hepatic stellate cells (HSCs) play an essential role in various liver diseases, and exosomes are critical mediators of intercellular communication in local and distant microenvironments. Cellular crosstalk between HSCs and surrounding multiple tissue-resident cells promotes or inhibits the activation of HSCs. Substantial evidence has revealed that HSC-derived exosomes are involved in the occurrence and development of liver diseases through the regulation of retinoid metabolism, lipid metabolism, glucose metabolism, protein metabolism, and mitochondrial metabolism. HSCderived exosomes are underpinned by vehicle molecules, such as mRNAs and microRNAs, that function in, and significantly affect, the processes of various liver diseases, such as acute liver injury, alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, fibrosis, and cancer. As such, numerous exosomes derived from HSCs or HSCassociated exosomes have attracted attention because of their biological roles and translational applications as potential targets for therapeutic targets. Herein, we review the pathophysiological and metabolic processes associated with HSC-derived exosomes, their roles in various liver diseases and their potential clinical application.

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Section: Chronic Viral Hepatitismentioning

confidence: 99%

Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases

Yin¹,

Li²,

Song³

et al. 2022

J Clin Transl Hepatol

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“…EVs can also carry microRNA, downgrade inflammatory response in neighbouring macrophages and induce macrophage polarization (Ganguly et al, 2022). Therefore, EVs and their bioactive substances can be potentially used as biomarkers for disease diagnosis, drug delivery and prediction of disease prognosis and clinical outcomes for infectious disease (Choi et al, 2020;Hu et al, 2021;Jung et al, 2023). (Manzoor et al, 2023).…”

Section:  Of mentioning

confidence: 99%

Extracellular vesicles and endothelial dysfunction in infectious diseases

Zhang,

Chi,

et al. 2024

J of Extracellular Bio

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Cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity globally. Studies have shown that infections especially bacteraemia and sepsis are associated with increased risks for endothelial dysfunction and related CVDs including atherosclerosis. Extracellular vesicles (EVs) are small, sealed membrane‐derived structures that are released into body fluids and blood from cells and/or microbes and are critically involved in a variety of important cell functions and disease development, including intercellular communications, immune responses and inflammation. It is known that EVs‐mediated mechanism(s) is important in the development of endothelial dysfunction in infections with a diverse spectrum of microorganisms including Escherichia coli, Candida albicans, SARS‐CoV‐2 (the virus for COVID‐19) and Helicobacter pylori. H. pylori infection is one of the most common infections globally. During H. pylori infection, EVs can carry H. pylori components, such as lipopolysaccharide, cytotoxin‐associated gene A, or vacuolating cytotoxin A, and transfer these substances into endothelial cells, triggering inflammatory responses and endothelial dysfunction. This review is to illustrate the important role of EVs in the pathogenesis of infectious diseases, and the development of endothelial dysfunction in infectious diseases especially H. pylori infection, and to discuss the potential mechanisms and clinical implications.

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“…Therefore, it is essential to identify potential responders and non-responders before starting Peg-IFN therapy. Exosomal miR-194-5p, miR-22-3p, and IFITM2 can improve prediction accuracy and reduce the treatment exposure for these potential non-responders [ 67 , 139 ].…”

Section: Potential Applications Of Exosomes In Hepatitis Bmentioning

confidence: 99%

Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment

Wu,

Niu,

Shi

2024

J Nanobiotechnol

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Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due to its hepatotropism, the hepatitis B virus (HBV) cannot infect other cells. The mechanisms underlying the intercellular communication among different liver cells in HBV-infected individuals and the immune microenvironment imbalance remain elusive. Exosomes, as important intercellular communication and cargo transportation tools between HBV-infected hepatocytes and immune cells, have been shown to assist in HBV cargo transportation and regulate the immune microenvironment. However, the role of exosomes in hepatitis B has only gradually received attention in recent years. Minimal literature has systematically elaborated on the role of exosomes in reshaping the immune microenvironment of the liver. This review unfolds sequentially based on the biological processes of exosomes: exosomes’ biogenesis, release, transport, uptake by recipient cells, and their impact on recipient cells. We delineate how HBV influences the biogenesis of exosomes, utilizing exosomal covert transmission, and reshapes the hepatic immune microenvironment. And based on the characteristics and functions of exosomes, potential applications of exosomes in hepatitis B are summarized and predicted. Graphical Abstract

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Baseline serum exosome‐derived miRNAs predict HBeAg seroconversion in chronic hepatitis B patients treated with peginterferon

Cited by 10 publications

References 35 publications

Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases

Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases

Extracellular vesicles and endothelial dysfunction in infectious diseases

Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment

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