Baseline Values of Circulating IL-6 and TGF-β Might Identify Patients with HNSCC Who Do Not Benefit from Nivolumab Treatment

Merlano, Marco Carlo; Paccagnella, Matteo; Denaro, Nerina; Abbona, Andrea; Galizia, Danilo; Sangiolo, Dario; Gammaitoni, Loretta; Fiorino, Erika; Minei, Silvia; Bossi, Paolo; Licitra, Lisa; Garrone, Ornella

doi:10.3390/cancers15215257

Cited by 2 publications

(1 citation statement)

References 53 publications

(60 reference statements)

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“…Interestingly, elevated IL-6 values in serum collected prior to nivolumab therapy of HNSCC at patients were correlated with their poor survival [ 12 ]. Also, Tsai et al data revealed that IL-6 overexpression was associated with the increased risk of developing disease failure and poor prognosis for HNSCC [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features

Ostrowska,

Niewinski,

Piotrowski

et al. 2024

Clin Transl Oncol

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Background Cellular senescence is a state characterized by cell-cycle arrest and apoptotic resistance. Senescence in cancer may be induced by oncogenes or therapy. While cellular senescence might play an important role in protection against cancer development, elevated and uncontrolled senescent cells accumulation may promote carcinogenesis by secreting a collection of pro-inflammatory factors, collectively termed the senescence-associated secretory phenotype (SASP). Material and methods We determined the gene expression at mRNA level of selected cellular senescence markers (p16 and LMNB1) and SASP factors (IL-6, IL-1b, CXCL-1 and TNF-α) in 72 cancerous tissues and 64 normal tissues obtained from patients with head and neck squamous cell carcinoma (HNSCC) and correlated this data with patients’ clinical follow-up. Results Our results indicate higher levels of selected SASP factors in cancerous compared to normal tissues. We presented the relationship between SASP factors expression at the transcript level and the progression of the disease. Moreover, we proposed CXCL1 as a candidate biomarker differentiating normal tissues from cancerous ones and IL1b expression as a molecular factor related to increased TNM stage. Conclusion Our primary study indicates that SASP expression may be associated with some clinicopathological features. However, a more detailed study is needed to present specific role of senescence-related mechanism and SASPs especially in tumor therapy response and in relation to the patient’s immune system condition.

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Section: Discussionmentioning

confidence: 99%

Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features

Ostrowska,

Niewinski,

Piotrowski

et al. 2024

Clin Transl Oncol

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Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

Liu,

Han,

Wang

et al. 2024

Environmental Toxicology

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BackgroundHead and neck squamous cell carcinoma (HNSCC) presents a significant clinical challenge, particularly due to its high propensity for locoregional recurrence. Current research underscores the need to unravel the complex interactions within the tumor microenvironment. This study addresses the critical gap in understanding how FOS modulates the immune landscape in HNSCC, with a focus on its influence on fibroblast and myeloid cell dynamics.MethodsEmploying a comprehensive approach, we analyzed tissue samples from HNSCC patients and adjacent non‐cancerous tissues using bulk RNA sequencing complemented by in‐depth bioinformatics analyses, including gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis, and immune infiltration assessment. A pivotal aspect of our research involved dissecting single‐cell RNA‐seq data from GSE234933 to elucidate the cell‐type‐specific expression of FOS.ResultsWe found that FOS expression varies significantly in different cell populations in the HNSCC tumor microenvironment, especially in fibroblasts and myeloid cells. This expression difference may reflect the different roles of these cells in tumor progression and their impact on the tumor microenvironment.ConclusionOur results uncover a significant correlation between FOS expression and key immune and hypoxia‐related pathways, suggesting its integral role in the tumor microenvironment. These findings not only enhance our understanding of HNSCC pathogenesis but also highlight FOS as a potential therapeutic target. This study marks a significant step towards addressing the urgent need for targeted interventions in HNSCC, particularly in the context of locoregional recurrence.

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Baseline Values of Circulating IL-6 and TGF-β Might Identify Patients with HNSCC Who Do Not Benefit from Nivolumab Treatment

Cited by 2 publications

References 53 publications

Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features

Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features

Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC

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