Basic Concepts of High-Voltage Pulse Generation

Redondo, Luis

doi:10.1007/978-3-319-26779-1_209-1

Cited by 2 publications

(10 citation statements)

References 18 publications

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“…For electroporation research it is essential to have a pulse generator suitable to deliver controllable energy to biological tissue via application of repetitive electrical pulses with the predefined pulse waveform, voltage amplitude and pulse widths. The pulse forming circuits of the electroporator can be based on relatively simple circuits, which are discussed in the following works [15,[26][27][28]34,[38][39][40][41][42] and summarized in this section. The energy delivery can be provided by capacitor, inductor or transmission lines with the control of the switching element.…”

Section: Basic Generator Topologiesmentioning

confidence: 99%

“…The output voltage will be the sum of the voltages from separate stages, so adjusting the output voltage is possible. However, many stages are required to have enough output voltage levels, which consequently increases the cost of the device [38,39].…”

Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%

“…In case when the semiconductor switches are used, a partial discharge of the capacitors can be achieved. The output voltages are frequently determined by the switch breakdown voltage and the number of stages, however, devices in the range of 1-6 kV are common [31,39,53]. The circuit includes several galvanically isolated high-voltage power supplies V1,2...n. Each is controlled individually and can be set to a different amplitude.…”

Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%

“…In case when the semiconductor switches are used, a partial discharge of the capacitors can be achieved. The output voltages are frequently determined by the switch breakdown voltage and the number of stages, however, devices in the range of 1-6 kV are common [31,39,53]. The full Marx topology is based on separate stages/cells, where each stage has an energy storing capacitor C, a resistor R and a switch SW.…”

Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%

“…While the up to date review of commercial available PEF generators is available [27], there is no (at our knowledge) extensive overview of in-house built nanosecond and high-frequency electroporators. Currently, the works are mainly focused on the review of the general topologies used for generator design [28,30,[34][35][36][37][38][39][40]. In the scope of this article, we reviewed the scientific papers reporting the developed nsPEF generators for electroporation in the last two decades.…”

Section: Introductionmentioning

confidence: 99%

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Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art

et al. 2020

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Electroporation is a pulsed electric field triggered phenomenon of cell permeabilization, which is extensively used in biomedical and biotechnological context. There is a growing scientific demand for high-voltage and/or high-frequency pulse generators for electropermeabilization of cells (electroporators). In the scope of this article we have reviewed the basic topologies of nanosecond pulsed electric field (nsPEF) generators for electroporation and the parametric capabilities of various in-house built devices, which were introduced in the last two decades. Classification of more than 60 various nsPEF generators was performed and pulse forming characteristics (pulse shape, voltage, duration and repetition frequency) were listed and compared. Lastly, the trends in the development of the electroporation technology were discussed.

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Section: Basic Generator Topologiesmentioning

confidence: 99%

Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%

Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%

“…In case when the semiconductor switches are used, a partial discharge of the capacitors can be achieved. The output voltages are frequently determined by the switch breakdown voltage and the number of stages, however, devices in the range of 1-6 kV are common [31,39,53]. The full Marx topology is based on separate stages/cells, where each stage has an energy storing capacitor C, a resistor R and a switch SW.…”

Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%