The analytic method of optimization of production process models is developed in this article. The purpose is the optimization of work schedule based on using mathematic methods in operational management of operational processes of flexible production systems in machine-building enterprises. The task of constructing an optimal production schedule for jobs is being considered (work modules or centers), which is the systems of operational management of flexible production’ core. The author offers a model of the dynamics of the intellectual potential of the enterprise, which will improve the efficiency of its use and can be used as a tool for analysis and management of the company's intellectual capital in the process of innovative development. Theoretical and methodological base of researching the problem is the mathematic modeling and systematic approach, on the basis of which the specific features of interrelated factors are analyzed, which define the complex nature of flexible engineering, which are essential for development and realization the effective system of operational management. The proposed method can be used in improving operational management systems during the organization of flexible production and in the process of its functioning under various external and internal changes.