We address the question of the intrinsic relation between mass, gravity, spacetime symmetry, and the Higgs mechanism implied by involvement of the de Sitter vacuum as its basic ingredient (a false vacuum). Incorporating the de Sitter vacuum, the Higgs mechanism implicitly incorporates the generic relation between mass, gravity, and spacetime symmetry revealed in the frame of General Relativity for all objects involving the de Sitter vacuum. We overview two observational cases which display and verify this relation, the case known as "negative mass square problem" for neutrino, and appearance of a minimal length scale in e + e − annihilation.