Basic Mechanisms of the Aging Gastrointestinal Tract

Salles, Nathalie

doi:10.1159/000099474

Cited by 152 publications

(82 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Este grupo etario es más vulnerable a experimentar defi ciencias de micronutrientes debido a un menor consumo de alimentos por limitaciones socioeconómicas, aislamiento social, menor actividad física o por una anorexia originada por alteraciones sensoriales, consumo de algunos medicamentos o a factores psicológicos 5,6 . A esto se agregan difi cultades en la digestión por problemas en la masticación por la pérdida de piezas dentales y en la absorción de algunos nutrientes a consecuencias de posibles alteraciones en la función gastrointestinal 7,8 .…”

unclassified

Prevalencia de las deficiencias de zinc y cobre en adultos mayores de la Región Metropolitana de Santiago

et al. 2011

View full text Add to dashboard Cite

unclassified

Prevalencia de las deficiencias de zinc y cobre en adultos mayores de la Región Metropolitana de Santiago

et al. 2011

View full text Add to dashboard Cite

“…Another reason is the age-related differences in bowel function, which have been reported in able-bodied person. 18 In able-bodied person, it is commonly assumed that chronic constipation or changes in colonic function are natural consequences of the aging process, 18 reflecting the tendency for a longer mean colonic transit time in the elderly. 18 Furthermore, it is possible that the elderly group perform less favorably compared with young groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of age on bowel management in traumatic central cord syndrome

Furusawa¹,

Tokuhiro²,

Ikeda³

et al. 2011

Spinal Cord

View full text Add to dashboard Cite

Study Design: A retrospective multicenter study. Objectives: To investigate the characteristics of bowel dysfunction in elderly people with traumatic central cord syndrome (TCCS). Setting: A total of 28 Rosai hospitals in Japan. Methods: The Rosai Hospital registry included 3006 persons with spinal cord injury during 1997-2007. The study subjects were 186 patients with TCCS (160 men, 26 women; mean age, 61.7 ± 11.6 years, ± s.d.). Patients were divided according to age into the young group (o50 years, n ¼ 30), the middle-age group (50-69 years, n ¼ 112) and the elderly group (X70 years, n ¼ 44). We assessed the differences in bowel management techniques (spontaneous, rectal medications and manual emptying) and activity of daily living (ADL) with respect to bowel care at discharge among the three groups. Results: Continent spontaneous defecation was the most common bowel management method (50%, 93/186). The percentage of elderly subjects on continent spontaneous defecation (36.4%) was significantly less than that of the young group (66.7%; Po0.05). Furthermore, the percentage of elderly patients who required no bowel care (18.2%) was significantly less than those of the young (53.3%) and middle-age groups (41.1%; Po0.01). However, few differences in bowel care-related ADL were recognized among the three groups in patients who required manual emptying. Conclusion: The results identified significantly fewer patients aged X70 years with 'continent spontaneous defecation' or 'independent for bowel care' compared with younger patients. The results also highlighted the clinical importance of bowel dysfunction associated with TCCS especially in elderly people.

show abstract

“…Ageing is typically accompanied by a milieu of changes including substantiated alterations and deterioration of gut functions, such as secretion of digestive fluids and enzymes, saliva, GIT contractions and chyme passage rates (Di Francesco et al, 2005;Feldman, Cryer, McArthur, Huet, & Lee, 1996;Laugier, Bernard, Berthezene, & Dupuy, 1991;Nagler & Hershkovich, 2005;Russell et al, 1993;Salles, 2007;Vellas et al, 1988). Due to the irreversible nature of the changes in GIT functions, there is a growing need to deepen our understanding of foods' digestive fate in the elderly GI.…”

Section: Elderlymentioning

confidence: 99%

Extending in vitro digestion models to specific human populations: Perspectives, practical tools and bio-relevant information

Shani-Levi

Alvito

Andrés

et al. 2017

Trends in Food Science & Technology

154

View full text Add to dashboard Cite

a b s t r a c tBackground: In vitro digestion models show great promise in facilitating the rationale design of foods. This paper provides a look into the current state of the art and outlines possible future paths for developments of digestion models recreating the diverse physiological conditions of specific groups of the human population. Scope and approach: Based on a collective effort of experts, this paper outlines considerations and parameters needed for development of new in vitro digestion models, e.g. gastric pH, enzymatic activities, gastric emptying rate and more. These and other parameters are detrimental to the adequate development of in vitro models that enable deeper insight into matters of food luminal breakdown as well as nutrient and nutraceutical bioaccessibility. Subsequently, we present an overview of some new and emerging in vitro digestion models mirroring the gastro-intestinal conditions of infants, the elderly and patients of cystic fibrosis or gastric bypass surgery. Key findings and conclusions: This paper calls for synchronization, harmonization and validation of potential developments in in vitro digestion models that would greatly facilitate manufacturing of foods tailored or even personalized, to a certain extent, to various strata of the human population.

show abstract

Basic Mechanisms of the Aging Gastrointestinal Tract

Cited by 152 publications

References 73 publications

Prevalencia de las deficiencias de zinc y cobre en adultos mayores de la Región Metropolitana de Santiago

Prevalencia de las deficiencias de zinc y cobre en adultos mayores de la Región Metropolitana de Santiago

Effect of age on bowel management in traumatic central cord syndrome

Extending in vitro digestion models to specific human populations: Perspectives, practical tools and bio-relevant information

Contact Info

Product

Resources

About