Basic Principles of Oxygen Transport and Calculations

Vincent, Jean Louis; Theerawit, Pongdhep; Simion, Davide; Maniatis, Alice; Linden, Philippe Van der; Hardy, Jean‐François

doi:10.1002/9781444319583.ch17

Cited by 1 publication

(1 citation statement)

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“…An increased O 2 ER, calculated as [CaO 2 −CvO 2 ]/ CaO 2 ), is typically a marker of reduced DO 2 during earlystage shock, with a normal value of 25%-30%. [31] O 2 ER increases in hypoxic settings to match the metabolic demand, with an upper limit of 40%-50%. [32] O 2 ER is almost equal to 1−SvO 2 when arterial O 2 saturation (SaO 2 ) is 100%.…”

Section: O 2 Extraction Rate (O 2 Er)mentioning

confidence: 99%

Blood gas analysis as a surrogate for microhemodynamic monitoring in sepsis

Wang,

Weng,

et al. 2023

World Journal of Emergency Medicine

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BACKGROUND: Emergency patients with sepsis or septic shock are at high risk of death. Despite increasing attention to microhemodynamics, the clinical use of advanced microcirculatory assessment is limited due to its shortcomings. Since blood gas analysis is a widely used technique reflecting global oxygen supply and consumption, it may serve as a surrogate for microcirculation monitoring in septic treatment. METHODS:We performed a search using PubMed, Web of Science, and Google scholar. The studies and reviews that were most relevant to septic microcirculatory dysfunctions and blood gas parameters were identified and included. RESULTS:Based on the pathophysiology of oxygen metabolism, the included articles provided a general overview of employing blood gas analysis and its derived set of indicators for microhemodynamic monitoring in septic care. Notwithstanding flaws, several parameters are linked to changes in the microcirculation. A comprehensive interpretation of blood gas parameters can be used in order to achieve hemodynamic optimization in septic patients.CONCLUSION: Blood gas analysis in combination with clinical performance is a reliable alternative for microcirculatory assessments. A deep understanding of oxygen metabolism in septic settings may help emergency physicians to better use blood gas analysis in the evaluation and treatment of sepsis and septic shock.

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Section: O 2 Extraction Rate (O 2 Er)mentioning

confidence: 99%