Basic Principles of the Using of Medicinal Plants and Their Collections for Treatment and Prevention of Diabetes Mellitus Type 2 (Literature Review)

Savych, Alona; Marchyshyn, S. М.; Kozyr, G. R.; Skrynchuk, O. Ya.

doi:10.33617/2522-9680-2019-4-43

Cited by 5 publications

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“…In addition, the hydrolysis of bound carbohydrates led to the formation of polyalcohols, of which two were found in samples 1, 2, 3 and 5, and three polyalcohols in sample 4 (Figs. 2,4,6,8,10).…”

Section: Qualitative Analysesmentioning

confidence: 99%

“…The combinations of different medicinal plants deserve particular attention. Herbal mixtures are expected to have several biologically active substances with a wide range of pharmacological actions and a variety of mechanisms for influencing the development of diabetes (pathogenesis of which involves the development of insulin resistance, relative insulin deficiency, which leads to the decrease of secretory activity of β-cells of the pancreatic gland) and diabetic angiopathies (inactivation of the antioxidant protection system, activation of lipid peroxidation and development of oxidative stress) (6)(7)(8).…”

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Determination of carbohydrates in the herbal antidiabetic mixtures by GC-MC

2020

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Due to the wide range of biologically active substances, the herbal mixtures can influence the development of diabetes mellitus and its complications. Carbohydrates attract particular attention due to their hypoglycemic, hypolipidemic, anticholesterolemic, antioxidant, antiinflammatory and detoxifying activities. The aim of this study was to investigate the content of carbohydrates through their monomeric composition in the herbal mixture samples: a) Urtica dioica leaf, Cichorium intybus roots, Rosa majalis fruits, Elymys repens rhizome, Taraxacum officinale roots, b) Arctium lappa roots, Elymys repens rhizome, Zea mays columns with stigmas, Helichrysum arenarium flowers, Rosa majalis fruits, c) Inula helenium rhizome with roots, Helichrysi arenarium flowers, Zea mays columns with stigmas, Origanum vulgare herb, Rosa majalis fruits, Taraxacum officinale roots, d) Cichorium intybus roots, Elymys repens rhizome, Helichrysum arenarium flowers, Rosa majalis fruits, Zea mays columns with stigmas and e) Urtica dioica leaf, Taraxacum officinale roots, Vaccinium myrtillus leaf, Rosa majalis fruits, Mentha piperita herb, which were used in Ukrainian folk medicine for the prevention and treatment of diabetes mellitus type 2.The carbohydrates were separated by gas chromatography-mass spectrometry after conversion into volatile aldononitrile acetate derivatives. The monomeric composition of polysaccharides was studied after their hydrolysis to form monosaccharides and poly-alcohols.Quantitative analyses of free carbohydrates showed that the predominant sugars were fructose, glucose and disaccharide – sucrose, in all samples. Concerning the determination of polysaccharide monomers after hydrolysis, glucose was the most abundant in all samples. The chromatographic study revealed a number of polyalcohols that are important for the treatment and prevention of progression of diabetes mellitus and its complications, namely, mannitol, pinitol and myo-inositol.

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Section: Qualitative Analysesmentioning

confidence: 99%

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confidence: 99%

Determination of carbohydrates in the herbal antidiabetic mixtures by GC-MC

2020

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Screening study of hypoglycemic activity of the herbal mixtures (message 1)

Savych

Marchyshyn

Basaraba

2020

ScienceRise: Pharmaceutical Science

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The aim. To study the hypoglycemic activity of the herbal mixtures, which are used in folk medicine for the prevention and treatment of diabetes mellitus type 2, but do not have a scientific basis and to establish their conditional therapeutic dose. Materials and methods. The study was performed on male albino rats weighing 180-200 g, which for preventive treatment during 20 days orally received aqueous extracts (1:10) of the studied herbal mixtures at a dose 6 mL/kg/day, 9 mL/kg/day and 12 mL/kg/day and comparison drugsthe officinal herbal mixtures "Arfazetin" at a dose 9 mL/kg/day and metformin tablets at a dose 60 mg/kg/day. The stu dy of hypoglycemic properties and the establishment of a conditional therapeutic dose of the studied mixtures was carried out u sing glucose loading tests. All experiments were performed in accordance with general ethical principles with the recommendations of the EEC Council directive 2010/63/EU about the protection of animals, which are used for scientific purposes. Results. The results of the study showed that the 20-day preventive treatment by the herbal mixtures reduced alimentary hyperglycemia at the 30th minutes of OGTT and helped regulate carbohydrate tolerance disorders by reducing hyperglycemia at the 15th minutes of IPGTT. The highest hypoglycemic activity showed the herbal mixtures No. 3 (12 mL/kg/day) and No. 4 (12 mL/kg/day), which was almost on a par with the comparison drugmetformin tablets, but exceeded the officinal herbal mixture "Arfazetin". In addition, the dose-dependence of the effectiveness of all five studied herbal mixtures was established. Conclusions. For the first time, it was conducted the screening study of hypoglycemic activity of the herbal mixtures, which are used in folk medicine for the prevention and treatment of diabetes mellitus type 2. It was determined that the greatest effectiveness in terms of the ability to reduce alimentary hyperglycemia during OGTT and reduce impaired carbohydrate tolerance during IPGTT show the herbal mixtures No. 3 (which includes Urticea folia, Cichorii radices, Rosae fructus, Elymi repens rhizomata, Taraxaci radices) and No. 4 (which includes Arctii lappae radices, Elymi repens rhizomata, Maydis style cum sigmatis, Helichrysi arenarii flores, Rosae fructus). It was established their conditional therapeutic dose of 12 mL/kg/day

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Determination of fatty acid composition content in the herbal antidiabetic collections

Savych¹,

Marchyshyn²,

Basaraba³

2020

PHAR

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It was determined the qualitative composition and the quantitative content of fatty acids in the herbal antidiabetic collection № 3, № 4, № 7, № 13, № 19, which are used in folk medicine for prevention and treatment of diabetes mellitus type 2 in Ukraine by GC/MS method. According to the results it was identified 8 fatty acids in the herbal antidiabetic collection № 3, 13 fatty acids in the herbal antidiabetic collection № 4, 12 fatty acids in the herbal antidiabetic collection № 7, 13 fatty acids in the herbal antidiabetic collection № 13 and 11 fatty acids in the herbal antidiabetic collection № 19. The saturated fatty acids were found to be dominated in the raw plant material. The results of the quantitative research showed that the herbal antidiabetic collection № 3 contains 16.13 mg/g of fatty acids, the herbal antidiabetic collection № 4 – 27.17 mg/g, the herbal antidiabetic collection № 7 – 31.98 mg/g, the herbal antidiabetic collection № 13 – 27.37 mg/g, the herbal antidiabetic collection № 19 – 18.79 mg/g. The GC/MS analysis of the fatty acid composition in the herbal antidiabetic collections has shown that this raw material has a lot of fatty acids, which can have a positive effect for the treatment and prevention of diabetes mellitus type 2.

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Basic Principles of the Using of Medicinal Plants and Their Collections for Treatment and Prevention of Diabetes Mellitus Type 2 (Literature Review)

Cited by 5 publications

References 0 publications

Determination of carbohydrates in the herbal antidiabetic mixtures by GC-MC

Determination of carbohydrates in the herbal antidiabetic mixtures by GC-MC

Screening study of hypoglycemic activity of the herbal mixtures (message 1)

Determination of fatty acid composition content in the herbal antidiabetic collections

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