Basics of study design: Practical considerations

Chatburn, Robert L

doi:10.3949/ccjm.84.s2.03

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…First, RCTs are financially costly and time-consuming, particularly for rare outcomes or conditions requiring long-term follow-up. Second, RCTs may not always yield therapies that selectively affect the intended risk factors, and crucially, random assignment of many risk factors is often not feasible due to practical or ethical constraints (42). MR offers a time-and costeffective alternative for uncovering causal relationships (43).…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study

Ma,

Xu,

Xie

et al. 2023

Front. Med.

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BackgroundA potential link between asthma and frailty has been suggested in previous studies. However, the nature of the causal relationship between these two conditions warrants further investigation. Therefore, this study assessed the bidirectional causality between asthma and frailty risk using two-sample Mendelian randomization (MR).MethodsThe study data were obtained from the genome-wide association study (GWAS) dataset, with 337,159 samples representing asthma data and 175,226 samples representing frailty. The causal relationship between the two disorders was assessed by selecting the single nucleotide polymorphisms (SNPs), significantly associated with both asthma and frailty. The inverse variance weighting (IVW) method was used as the main analytical method to estimate the possible influence of causality. Sensitivity analysis was also performed using Mr-Egger intercept, funnel plot, “leave-one-out,” and Cochran Q test. In addition, potential mediators were investigated by risk factor analysis.ResultThe IVW method showed an increased risk of frailty due to increased genetic susceptibility factors and the number of to asthma (OR = 2.325, 95%CI:1.958–2.761; p = 6.527498e-22), while no horizontal pleiotropy was observed for the Mr-Egger intercept (p = 0.609) and the funnel plot. The Cochran Q value was 72.858, p = 0.024, and there was heterogeneity in the Cochran Q-value. No single SNP was observed for “leave-one-out” that had a biasing effect on the instrumental variables. In addition, genetic susceptibility to frailty was associated with asthma (OR = 1.088, 95%CI:1.058–1.119; p = 4.815589e-09). In the causal relationship described above, several risk factors for frailty are complex, with asthma leading to a significant reduction in physical activity endurance.ConclusionOur findings suggest a probable positive causal effect of asthma on the risk of developing frailty, potentially mediated by reduced physical activity endurance. At the same time, a causal relationship exists between frailty and asthma. Therefore, assessment strategies for frailty should include asthma and vice versa.

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Section: Discussionmentioning

confidence: 99%

The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study

Ma,

Xu,

Xie

et al. 2023

Front. Med.

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Evaluation of the design and methodology of applications to the local ethics committee

Altuntas

2021

Sisli Etfal

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Objectives: Proposals for scientific studies must have an original hypothesis and the appropriate design and methodology to test the premise. Methods: This study is an evaluation of the suitability of applications submitted to a local ethics committee (EC) and the rate of publication of that research. Results: A total of 899 files submitted for EC approval were retrospectively assessed. The EC found that the description of the methods in 44% of the applications was inaccurate, and that this type of error was most often seen in submissions from the surgical branch. In all, 52% of the applications for which we were informed about their final status were not published. Conclusion: The results suggest that improved training in epidemiology is required to reduce the number of application errors and that new regulations could help to motivate healthcare personnel to conduct scientific research and publish their findings.

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Basics of study design: Practical considerations

Cited by 2 publications

References 9 publications

The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study

The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study

Evaluation of the design and methodology of applications to the local ethics committee

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