Basilar Artery Aneurysm in a Woman With Syphilis

Figueiredo, Nathália Stela Visoná de; Angst, Débora Bartzen Moraes; Mendes, Lucas Silvestre; Machado, Michel Ferreira; Rocha, Maria Sheila Guimarães; Brucki, Sônia Maria Dozzi

doi:10.1001/jamaneurol.2015.0154

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…There is known association of another spirochete, Treponema pallidum causing syphilis, to aneurysm formation, indicates that there might be a causative relationship between Lyme disease, similar to syphilis in different stages of the disease, and aneurysm formation (76, 77). It is worth pointing out that a recent study on a group of 96 patients diagnosed with abdominal aortic aneurysms points out to a link between infection with B. burgdorferi and abdominal aortic aneurysms (78).…”

Section: Discussionmentioning

confidence: 99%

Cerebrovascular Manifestations of Lyme Neuroborreliosis—A Systematic Review of Published Cases

Garkowski

Zajkowska

et al. 2017

Front. Neurol.

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BackgroundLyme neuroborreliosis (LNB) is a disease caused by spirochete Borrelia burgdorferi, involving the nervous system. It usually manifests as lymphocytic meningoradiculitis, but in rare cases, it can also lead to cerebrovascular complications. We aimed to perform a systematic review of all reported cases of LNB complicated by central nervous system vasculitis and stroke or transient ischemic attack (TIA).Materials and methodsWe conducted a systematic review of literature between May 1987 and December 2016 with patients who presented with cerebrovascular course of LNB.ResultsThis study included 88 patients with a median age of 46 years. The median interval from onset of symptoms suggesting Lyme disease to first symptoms of cerebrovascular manifestations of LNB was 3.5 months. The most common cerebrovascular manifestation of LNB was ischemic stroke (76.1%), followed by TIA (11.4%). The posterior circulation was affected alone in 37.8% of patients, the anterior circulation in 24.4% of patients, and in 37.8% of cases, posterior and anterior circulations were affected simultaneously. The most common affected vessels were middle cerebral artery—in 19 cases, basilar artery—in 17 cases, and anterior cerebral artery—in 16 cases. A good response to antibiotic treatment was achieved in the vast number of patients (75.3%). The overall mortality rate was 4.7%.ConclusionCerebral vasculitis and stroke due to LNB should be considered, especially in patients who live in or have come from areas with high prevalence of tick-borne diseases, as well as in those without cardiovascular risk factors, but with stroke-like symptoms of unknown cause.

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Section: Discussionmentioning

confidence: 99%

Cerebrovascular Manifestations of Lyme Neuroborreliosis—A Systematic Review of Published Cases

Garkowski

Zajkowska

et al. 2017

Front. Neurol.

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“…51,68 Aneurysm formation has also been reported. 55,69,70 Pathology There is good correlation between clinical findings and pathology. On pathologic examination, diffuse thickening and fibrosis of the leptomeninges, rarely containing miliary gummas are seen.…”

Section: Imagingmentioning

confidence: 96%

Infectious Etiologies of Stroke

Shulman

Cervantes‐Arslanian

2019

Semin Neurol

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Central nervous system (CNS) infections are a frequently underappreciated potential etiology of cerebrovascular disease. Highlighted in this review are a selection of infectious agents that lead to cerebrovascular complications through various mechanisms including multifocal vasculopathy, focal infiltrative vasculitis and vasospasm, and direct vessel wall invasion and thrombus formation. Diagnosis of stroke due to underlying CNS infection requires a high index of clinical suspicion and careful consideration of neuroimaging, serum, and cerebrospinal fluid studies in addition to a detailed history and neurologic examination. Prompt and targeted treatment is essential in these conditions, which frequently herald a poor prognosis. Specifically, cerebrovascular complications associated with varicella zoster virus, syphilis, tuberculosis, aspergillosis, and acute bacterial meningitis are addressed here in detail.

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Infectious Vasculitides of the Central Nervous System

Cervantes‐Arslanian

Anand

2020

Curr Treat Options Cardio Med

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Basilar Artery Aneurysm in a Woman With Syphilis

Cited by 4 publications

References 2 publications

Cerebrovascular Manifestations of Lyme Neuroborreliosis—A Systematic Review of Published Cases

Cerebrovascular Manifestations of Lyme Neuroborreliosis—A Systematic Review of Published Cases

Infectious Etiologies of Stroke

Infectious Vasculitides of the Central Nervous System

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