Basophil activation testing, IgG, and IgG4 in the diagnosis of dog allergy in children with and without a dog at home

Abstract

To the editor, Obesity/overweight has been shown to be associated with an increased risk of asthma in both adults and children in several meta-analyses. Although asthma and allergic rhinitis (AR) are closely linked by the "one airway, one disease" concept, 1 the relationship between obesity/overweight and AR in adults and children remains unknown. Evidence that obesity/overweight and AR have several comorbid conditions and both are related to an inflammatory state suggests a potential association between these conditions. Thus, we conducted a meta-analysis to explore the relationship between

Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy

“…Also, mono‐sensitization was more common than poly‐sensitization and found to be an important predictor of asthma severity with increased blood eosinophils, fractional exhaled nitric oxide and airway hyperreactivity 2 . This aligns well with other data on molecular allergy diagnostics to refine characterization of sensitization 3 and basophil activation testing in the diagnosis of dog allergy in children 4 . The importance of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence has also been reported in this year's Clinical and Experimental Allergy 5 .…”

EAACIMolecular Allergology User's Guide 2.0

“…The recombinant fusion proteins exhibited more than 1000‐fold reduced allergenic activity in BAT in comparison to Fel d 1 261 . Recombinant mosaic proteins generated by reassembly of non‐IgE‐reactive peptides of Fel d 1 similarly showed a strong reduction in allergenic activity 262 …”

“…261 Recombinant mosaic proteins generated by reassembly of non-IgE-reactive peptides of Fel d 1 similarly showed a strong reduction in allergenic activity. 262 The dog allergen Can f 6 is a major allergen in dog-allergic Chinese children and it demonstrated allergenic activity in BAT. 263 Recently, a panel of recombinant dog allergens (Can f 1-6) was quantified in commercial skin prick test (SPT) solutions of dog extracts, and allergenicity to dog extract was assessed by BAT in three patients.…”

“…With respect to allergen-specific IgG and IgG4, Käck et al found no significant differences in IgG-or IgG4 levels to dog dander or to any dog allergen molecule between dog dander sensitized children with a positive and a negative provocation test with dog dander extract. 262 They concluded that the responses rather reflected exposure than tolerance to dog, in line with the study by Burnett and colleagues. 819 Epidemiological studies have shown that the presence of animal childhood have shown to be predictive markers of cat or dog allergy in adolescence.…”

Diagnostics of Allergy to Furry Animals—Possibilities in 2024

“…No patient with a negative BAT response to dog fur ( n = 4) reported manifestations of respiratory disorders after contact with a dog. Furthermore, the authors stressed that the BAT can be a useful complementary tool to reduce overdiagnosis of a dog allergy, whilst the presence of IgG and IgG4 antibodies may reflect vulnerability to dogs, rather than tolerance to their allergens [ 53 ].…”