Basophil histamine release activity and disease severity in chronic idiopathic urticaria

Baker, Rosalyn; Vasagar, Kavitha; Ohameje, Nkiruka U.; Gober, Laura; Chen, Shuo; Sterba, Patricia M.; Saini, Sarbjit S.

doi:10.1016/s1081-1206(10)60449-8

Cited by 36 publications

(25 citation statements)

References 27 publications

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“…Two articles [29,35] reported the association between basophil function and CSU severity. Neither study found a significant difference between responders and nonresponders to basophil histamine release assay with regard to CSU severity.…”

Section: Resultsmentioning

confidence: 99%

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Rabelo-Filardi

Daltro-Oliveira

Campos

2013

Int Arch Allergy Immunol

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Background: Although some authors have already evaluated the predictive value of various parameters regarding the duration of chronic spontaneous urticaria (CSU), it remains uncertain which ones have importance in clinical practice as prognostic factors that indeed enable prediction. Similarly, some authors have investigated parameters that might be related to severe cases of CSU. However, the results of studies evaluating several parameters as markers of disease severity are fragmented. Thus, we performed a systematic review to summarize the findings of studies investigating the parameters associated with CSU duration and severity. Methods: Two authors independently searched PubMed until June 2012 for observational retrospective or prospective studies addressing clinical or laboratory parameters associated with disease duration or severity in CSU patients. Results: We found 1,136 potentially relevant published papers related to the subject, 34 of which were included in the systematic review. A total of 16, 6 and 12 articles evaluated CSU parameters on severity, duration or both, respectively. Conclusions: Our findings suggest that disease severity might predict CSU duration. Similarly, evidence suggests that plasma levels of prothrombin fragment 1 + 2, D-dimer and C-reactive protein may function as markers of CSU severity.

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Section: Resultsmentioning

confidence: 99%

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Rabelo-Filardi

Daltro-Oliveira

Campos

2013

Int Arch Allergy Immunol

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“…13 Studies to examine the relationship of disease activity to these functional categories are underway. 38 The altered protein expression of SHIP-1 and SHIP-2 phosphatases in basophils may also provide insights into pathways that are involved in CIU. Evidence suggests that the activities of SHIP-1 and SHIP-2 appear to be regulated in part by altering their protein expression as we observed in CIU NR and CIU R basophils.…”

Section: Discussionmentioning

confidence: 99%

Basophil FcɛRI histamine release parallels expression of Src-homology 2–containing inositol phosphatases in chronic idiopathic urticaria

Vonakis¹,

Vasagar²,

Gibbons³

et al. 2007

Journal of Allergy and Clinical Immunology

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109

121

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“…Adults with active CSU (ages 18-75) were recruited into an IRB-approved observational study between 2004 and 2012 at the Johns Hopkins Asthma and Allergy Center (6,7). Following informed consent, each participant completed a disease activity survey and underwent venipuncture during a routine clinic visit.…”

Section: Methodsmentioning

confidence: 99%

Interval shifts in basophil measures correlate with disease activity in chronic spontaneous urticaria

Oliver

Sterba

Saini

2015

Allergy

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Chronic spontaneous urticaria (CSU) significantly impacts the quality of life of those affected through symptoms of pruritus and recurrent skin lesions. In active CSU disease, reduced IgE-mediated basophil histamine release (HR) and basopenia are observed. We sought to examine the relationship between interval changes in basophil measures and shifts in patient-reported disease impairment. Simultaneous symptom and basophil evaluations were completed at two sequential study visits, and interval changes in measures were compared between visits for each subject (n = 38). These measures included Skindex-29, current itch and hives scores, total leukocyte histamine content (an indirect measure of blood basophil presence), and basophil HR in response to anti-IgE and formyl-methionine-leucine-phenylalanine. Overall, interval improvements in disease measures in CSU subjects were associated with increased basophil numbers (total leukocyte histamine content) and IgE-mediated HR. This suggests these measures are potential biomarkers for CSU disease improvement and further implicates a role for basophils in CSU.

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Basophil histamine release activity and disease severity in chronic idiopathic urticaria

Cited by 36 publications

References 27 publications

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Basophil FcɛRI histamine release parallels expression of Src-homology 2–containing inositol phosphatases in chronic idiopathic urticaria

Interval shifts in basophil measures correlate with disease activity in chronic spontaneous urticaria

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