Basophils drive the resolution and promote wound healing in adult and aged mice
Julie Bex,
Victoria Peter,
Chaimae Saji
et al.
Abstract:An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here, we show that basophils infiltrate the periphery of mouse skin wounds for at least three weeks, during both the inflammation and resolution phases of wound healing. Depletion of basophils induces an increased secretion of inflammatory molecules, accumulation and activation of… Show more
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