Basosquamöses Karzinom der Haut

Lehnerdt, Goetz; Manz, D.; Jahnke, K.; Schmitz, Klaus

doi:10.1007/s00106-007-1559-z

Cited by 6 publications

(9 citation statements)

References 17 publications

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“…Basosquamous carcinoma (BSC) is an uncommon skin cancer entity. As a rare variant or subtype of basal cell carcinoma (BCC), it features characteristics of both BCC (especially histologic characteristics) and squamous cell carcinoma (SCC; mainly clinical behavior) [1] , [2] , [3] , [4] , [5] . First described by MacCormac in 1910 [6] , BSC is a rare tumor with an incidence of less than 2% of all non-melanoma skin cancers and is predominant in men [5] , [7] , [8] , [9] .…”

Section: Introductionmentioning

confidence: 99%

“…First described by MacCormac in 1910 [6] , BSC is a rare tumor with an incidence of less than 2% of all non-melanoma skin cancers and is predominant in men [5] , [7] , [8] , [9] . Its etiology is multifactorial, but UV radiation, aging, and tobacco exposure seem to play key roles in the onset of BSC [1] , [5] , [10] , [11] . BSCs mainly occur in older Caucasian males and are usually located in the head and neck area (BSC-HN) or in other sun-exposed areas [5] , [7] , [12] .…”

Section: Introductionmentioning

confidence: 99%

“…BSC-HN appearance can vary and can include BCC signs (e.g., telangiectasia) or SCC characteristics or can appear as a palpable mass with or without ulceration. The symptoms of BSC-HN are not specific and depend on tumor location [1] , [5] , [20] , [21] , [22] . The histogenesis of BSC-HN is not yet clear, but it is thought that the tumor originates from totipotent cells in the basal layer [2] , [3] , [23] .…”

Section: Introductionmentioning

confidence: 99%

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Basosquamous Carcinoma of the Head and Neck: Clinical and Histologic Characteristics and Their Impact on Disease Progression

et al. 2015

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OBJECTIVES: Basosquamous carcinoma (BSC) is a rare tumor entity, and the most common onset is in the head and neck region (BSC-HN). The data on diagnosis, treatment, and especially risk assessment concerning disease course and outcome are deficient or inconsistent. This study aimed to evaluate risk factors for local relapse (LR) and lymph node metastasis (LNM) and their impact on progression-free survival (PFS). MATERIALS AND METHODS: In a retrospective monocentric study, patients with BSC-HN treated between 1999 and 2011 were analyzed regarding clinical and histologic characteristics. Prognostic parameters for LR, LNM, and PFS were evaluated. In total, 89 patients (55 male, 34 female, mean age of 71.8 years) with a mean follow-up time of 47.7 months (range 12-112) were included. RESULTS: LR occurred in four patients (4.5%), LNM occurred in five patients (5.6%). Patients with LNM had a significantly shorter PFS time (16.1 months) compared with patients without LNM (154.2 months; P < .001). Tumor depth and size (T classification), incomplete resection, localization at the ear, deep maximal vertical infiltration, muscle and vessel invasion all showed significant (P < .05) associations with LR, LNM, and shorter PFS time. BSC showed more histologic features of basal cell carcinoma (BCC), especially with regard to BerEP4 expression. CONCLUSION: While histology shows some typical characteristics of BCC, the biologic behavior and aggressiveness of BSC are similar to those of cutaneous squamous cell carcinoma. This is the first study to show that LR and, especially, LNM indicate a higher risk of an unfavorable outcome.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Basosquamous Carcinoma of the Head and Neck: Clinical and Histologic Characteristics and Their Impact on Disease Progression

et al. 2015

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“…6 years). [ 3 ] However, very rarely basosquamous carcinoma of skin in children with XP has been mentioned in literature. [ 4 ] Our patient is an 8-year-old child with dermal basaloid squamous cell carcinoma and XP.…”

Section: Discussionmentioning

confidence: 99%

Basaloid squamous carcinoma of skin associated with xeroderma pigmentosum in an 8-year-old child: A rare entity

et al. 2014

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Xeroderma pigmentosum (XP) is a rare autosomal recessive genodermatosis associated with hypersensitivity to ultraviolet (UV) light, due to defects in deoxyribonucleic acid (DNA) repair. Basaloid squamous cell carcinoma is a rare aggressive variant of squamous cell carcinoma. Patients with XP are at increased risk of developing cutaneous malignancy and are commonly associated with squamous carcinoma. We report an extremely rare case of 8-year-old child with XP along with basaloidsquamous carcinoma of skin; and review of literature related to it.

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“…Wichtig ist neben der vollständigen schnittrandkontrollierten Exzision die histologische Abgrenzung zum basaloiden Plattenepithelkarzinom, das im Gegensatz zum Basalzellkarzinom BerEp4-Antikörper-negativ ist [10].…”

Section: Basalzellkarzinomunclassified

Chronische und akute Analulzera

Weyandt¹

2009

Hautarzt

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Classic types of anal ulcers are acute and chronic anal fissure. Characteristic symptoms of chronic fissures are severe pain during defecation accompanied by the triad of ulceration, hypertrophic anal papilla and external skin tag. If the symptoms deviate other causes of ulceration must be considered. Primarily, malignancies should be excluded. The special setting in the anal fold, especially with concurrent immunosuppression, could lead to nonspecific manifestations of different proctological, dermatological and infectious diseases, which can only be clarified by further diagnostic workup and histopathology. Only the correct diagnosis will lead to causal and effective therapy. Successfully treated inflammatory dermatoses and precancerous lesions require regular follow-up because a recurrent or persistent course of the disease may result in malignant transformation.

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Basosquamöses Karzinom der Haut

Cited by 6 publications

References 17 publications

Basosquamous Carcinoma of the Head and Neck: Clinical and Histologic Characteristics and Their Impact on Disease Progression

Basosquamous Carcinoma of the Head and Neck: Clinical and Histologic Characteristics and Their Impact on Disease Progression

Basaloid squamous carcinoma of skin associated with xeroderma pigmentosum in an 8-year-old child: A rare entity

Chronische und akute Analulzera

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