Bat pluripotent stem cells reveal unusual entanglement between host and viruses

Déjosez, Marion; Marin, Arturo; Hughes, Graham M.; Morales, Ariadna E.; Godoy-Parejo, Carlos; Gray, Jonathan L.; Qin, Yiren; Singh, Arun A; Xu, Hui; Juste, Javier; Ibáñez, Carlos; White, Kris M.; Rosales, Romel; Francoeur, Nancy; Sebra, Robert; Alcock, Dominic; Volkert, Thomas L.; Puechmaille, Sébastien J.; Pastusiak, Andrzej; Frost, Simon D. W.; Hiller, Michael; Young, Richard A.; Teeling, Emma C.; García‐Sastre, Adolfo; Zwaka, Thomas P.

doi:10.1016/j.cell.2023.01.011

Cited by 32 publications

(11 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several bat species exhibit an exceptional lifespan and a remarkably low incidence of onco-genesis. Studies have revealed that their longevity may be attributed to attenuated senescence response, resulting from a dampened cGAS and STING pathway (Déjosez et al, 2023;Gorbunova et al, 2020).…”

Section: Cellular Senescencementioning

confidence: 99%

“…Several bat species exhibit an exceptional lifespan and a remarkably low incidence of oncogenesis. Studies have revealed that their longevity may be attributed to attenuated senescence response, resulting from a dampened cGAS and STING pathway (Déjosez et al., 2023; Gorbunova et al., 2020). Thus, given the unique mechanisms that bats have evolved to attenuate the senescence stage, further research in this area may yield valuable insights and novel approaches to combat age‐related diseases and promote healthy aging in humans.…”

Section: “Old” Hallmarks Of Aging—longevity Perspectivementioning

confidence: 99%

See 1 more Smart Citation

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova,

Savova,

Mihaylova

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

The revolution in aging research through the past decade has driven the progress in interventions that promote longevity. Dissection of the “old” hallmarks of aging has provided solid data for the definition of at least three “new” ones, opening avenues for the development of novel hallmark‐targeted pro‐longevity approaches. The quest for geroprotectors is of enormous interest with the ultimate goal of finding the alchemical stone that induces healthy aging and increases lifespan, pushing the limits of human longevity or even uncovering the absence of such limits. Several of the well‐appreciated geroprotectors that are recognized as longevity promoters are of natural origin such as metformin, resveratrol, aspirin, and spermidine. As the search for pharmacological modulators of healthspan and lifespan continues, numerous studies are focusing on the potential of plant secondary metabolites. The current review attempts to critically assess the available interventions and the breakthrough discoveries in the field of longevity research over the past decade. Correspondingly, novel approaches targeting the hallmarks of aging have been outlined, and the future goals in longevity research have been enlightened. Special emphasis has been placed on the potential of plant‐derived compounds as pro‐longevity agents.

show abstract

Section: Cellular Senescencementioning

confidence: 99%

Section: “Old” Hallmarks Of Aging—longevity Perspectivementioning

confidence: 99%

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova,

Savova,

Mihaylova

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

show abstract

“…For many proteins encoded by TE transcripts, their role and how they continue to escape transcriptional and translational silencing remain unclear. Recently, it was shown that certain reactivated and translated ERVs maintain the ability to form viral particles in mouse early embryos and in stem cells derived from bats (Déjosez et al, 2023 ; Ribet et al, 2008 ). In rare cases, however, the proteins translated from TE sequences have been shown to be adapted by the host and to contribute to the function of a healthy cell.…”

Section: Transcriptional Activation Of Tes During Developmentmentioning

confidence: 99%

Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo

Oomen,

Torres-Padilla

2024

EMBO Rep

View full text Add to dashboard Cite

Remnants of transposable elements (TEs) are widely expressed throughout mammalian embryo development. Originally infesting our genomes as selfish elements and acting as a source of genome instability, several of these elements have been co-opted as part of a complex system of genome regulation. Many TEs have lost transposition ability and their transcriptional potential has been tampered as a result of interactions with the host throughout evolutionary time. It has been proposed that TEs have been ultimately repurposed to function as gene regulatory hubs scattered throughout our genomes. In the early embryo in particular, TEs find a perfect environment of naïve chromatin to escape transcriptional repression by the host. As a consequence, it is thought that hosts found ways to co-opt TE sequences to regulate large-scale changes in chromatin and transcription state of their genomes. In this review, we discuss several examples of TEs expressed during embryo development, their potential for co-option in genome regulation and the evolutionary pressures on TEs and on our genomes.

show abstract

“…With this particular immune disposition, bats allow a low level of ongoing viral replication. In addition, bat stem cells contain a large number of endogenous viruses that can be activated under specific conditions (Déjosez et al., 2023 ). Even if bats represent a rich reservoir of mammalian viruses, bats come rarely in close contact with humans.…”

Section: Ecology‐oriented Searches For Candidate Pandemic Virusesmentioning

confidence: 99%

Pandemic preparedness: On the efficacy of non‐pharmaceutical interventions in COVID‐19 and about approaches to predict future pandemic viruses

Brüssow

2024

Microbial Biotechnology

View full text Add to dashboard Cite

With three major viral pandemics over the last 100 years, namely the Spanish flu, AIDS and COVID‐19 each claiming many millions of lives, pandemic preparedness has become an important issue for public health. The economic, social and political consequences of the upheaval caused by such pandemics also represent a major challenge for governments with respect to sustainable development goals. The field of pandemic preparedness is vast and the current article can only address selected aspects. The article looks first backwards and addresses the question of the efficacy of non‐pharmaceutical interventions (NPI) on the trajectory of the COVID‐19 pandemic. The article looks then forward by asking to what extent viral candidates for future pandemics can be predicted by virome analyses from metagenome and transcriptome sequencing, by focusing on the virome from specific animal species and using ecological and epidemiological data about spillover viral infections in veterinary and human medicine. As a comprehensive overview on pandemic preparedness is beyond the capacity of a single reviewer, only selected topics will be discussed using recent key scientific publications. Since COVID‐19 has not run its course, a computational program able to predict the future evolution of SARS‐CoV‐2 is mentioned that could assist proactive mRNA vaccine developments against possible future variants of concern. Ending the COVID‐19 epidemic necessitates mucosal vaccines that can suppress the transmission of SARS‐CoV‐2 and therefore this article closes by discussing a promising and versatile protein nanoparticle experimental vaccine approach for inhalation that does not depend on needles nor a cold chain for distribution.

show abstract

Bat pluripotent stem cells reveal unusual entanglement between host and viruses

Cited by 32 publications

References 118 publications

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo

Pandemic preparedness: On the efficacy of non‐pharmaceutical interventions in COVID‐19 and about approaches to predict future pandemic viruses

Contact Info

Product

Resources

About