Battling cancer: the latest on microwave hyperthermia

Bansal, Rajeev

doi:10.1109/mmw.2005.1511909

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…Antenna array synthesis techniques are very useful in the medical field, specifically related to the treatment of tumours by focused microwave or radiofrequency (RF) radiation. This method of focusing the beam by feeding the needed currents offers more controlled way of dealing with carcinoma using microwave hyperthermia [1][2][3]. A conformal array, with the precise current distribution can focus the antenna beam very precisely in the tumour-affected volume, with minimal radiation over the neighbouring healthy tissue [4][5][6][7].…”

Section: Applications Of Near-field Synthesis Techniquesmentioning

confidence: 99%

“…Coming back to the primary role in cancer treatment, tumours have traditionally been targeted by using radiation, chemotherapy and surgery, but alternative treatments for cancer are in the pipeline. Among the latter, Hyperthermia treatment is one of the more promising modalities against cancer, and in current times, it is transitioning from the experimental to clinical stage [1][2][3]. The mechanism behind hyperthermia therapy is based as follows: heating of cancer tissue by incident RF or microwave radiation sensitises the cells to the following radiation or chemotherapy treatment, sometimes even doubling the response, as compared with standalone radiation or chemotherapy [3].…”

Section: Near-field Focusing Using Conformal Array Technologymentioning

confidence: 99%

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Generalised method of current excitation reconstruction from near‐field data of planar, cylindrical and spherical antenna arrays

Sen¹,

Jerome-Surendran²,

Trivedi³

et al. 2013

IET Microwaves, Antennas & Propagation

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Currently chemotherapy, radiation and surgery are the widely accepted treatments for cancer. A fourth modality, hyperthermia, or heat treatment, is emerging as an adjuvant cancer treatment along with radiation or chemotherapy, and works as a booster, sometimes even doubling the effects of these standard treatments. Hyperthermia essentially heats the cancer region to around 42°C by precisely controlled electromagnetic radiation in the 27, 900 or 2400 MHz frequency range. The re-emergence of hyperthermia is primarily due to advanced antenna technology, which can precisely target the tumour volume, while delivering minimal energy to neighbouring healthy tissue. The precise focusing of the electromagnetic beam is realised either by focusing plates or lenses, or by conformal antenna arrays. In order to achieve efficient array near-field control for hyperthermia applications, electronic control of the array currents is essential to control the beam over the tumour volume and achieve uniform heating. This paper reports a generalised analytical technique to reconstruct the array currents from a specific near-zone electric field profile. This reconstruction technique is applicable to conformal arrays with planar, cylindrical or spherical geometry. Several simulations have been carried out to test the validity and accuracy of the reconstruction algorithm.

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Section: Applications Of Near-field Synthesis Techniquesmentioning

confidence: 99%

Section: Near-field Focusing Using Conformal Array Technologymentioning

confidence: 99%

Generalised method of current excitation reconstruction from near‐field data of planar, cylindrical and spherical antenna arrays

Sen¹,

Jerome-Surendran²,

Trivedi³

et al. 2013

IET Microwaves, Antennas & Propagation

View full text Add to dashboard Cite

show abstract

“…This method has found clinical application mostly in Europe and Asia [4,8]. While in the United States, microwave hyperthermia in conjunction with radiation has received approval from the Food and Drug Administration (FDA), it still remains mostly as an experimental method due to possible overheating and necrosis of normal tissue [11,12]. There is an urgent need for development of new hyperthermia heating agents and treatment methodologies that will be more effective than those currently available and help to unlock the full potential of the technology that can have a significant impact on management of cancer patients.…”

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confidence: 99%

Thermosensitive Magnetic Nanoparticles for Self-Controlled Hyperthermia Cancer Treatment

Martirosyan¹

2012

J Nanomedic Nanotechnol

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“…Recently, non-invasive microwave hyperthermia has been proposed as a promising alternative cancer treatment [26][27][28][29][30][31][32][33][34][35]. The benefits of this type of treatment, compared to other thermal treatments, is that it is a nonionising and non-invasive approach that can be applied to various types of cancer.…”

Section: Thermal Therapy In Cancer Treatmentmentioning

confidence: 99%

“…Despite the effectiveness of using microwave hyperthermia for the treatment of some cancers, its clinical application for breast cancer is still under development. This is mainly due to the inadequacy of required tools which restrict the utilisation of microwave hyperthermia in the treatment of breast cancer [5,7,35,45]. Generally, developing clinically effective systems for microwave hyperthermia will be difficult because it associates with solving several engineering problems within a complicated environment.…”

Section: Thermal Therapy In Cancer Treatmentmentioning

confidence: 99%

Focusing microwave hyperthermia in realistic environment for breast cancer treatment

Nguyen¹

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Microwave hyperthermia, a process that involves heating tumour cells, has been proposed as an alternative method of treating breast cancer. By sending microwave energy of a suitable frequency range to the breast, localised heating is induced by the applied electromagnetic radiation. It is important that the tumour is heated to a temperature greater than 42℃, (the required temperature for hyperthermia treatment) while keeping healthy tissue at normal body temperature. Several useful approaches have been proposed to direct microwave hyperthermia to cancerous tissue, including novel focusing methods and innovative microwave hardware designs. However, a number of challenges restricting the use of microwave systems in clinical medicine remain. Arguably, the most persisting engineering problem to overcome is achieving locally focused microwave power in the heterogeneous environment of the breast. In order to understand the challenges of microwave hyperthermia, considerably large computational efforts are required to solve 3D Electromagnetic (EM) problems in a complex model of breast tissue.The success of using microwave hyperthermia to treat breast cancer is highly dependent on the accuracy of the excitation signals utilised for each antenna element. Several research papers have reported various approaches on this topic. Although recent progress has been made in the investigation of microwave hyperthermia, the studies were mainly reliant upon oversimplified Radio Frequency (RF) models which assume point source applicators, and human breast phantoms which are mostly 2D models lacking tissue thermal-electric properties. As a result, it is infeasible to implement the proposed systems for clinical applications. This thesis aims to address the limitations of these earlier studies by modelling and constructing realistic human breast models and 3D antenna arrays. This will require the determination of correct phases and amplitudes for the excitation signals in a realistic environment by using a global optimisation method.The approaches proposed use actual antenna arrays to transmit microwave power while the excitation signals are optimised based on power distributions and thermal profiles induced in the patient-specific breast models. The first study based on 2D antenna arrays and patient-specific breast models is demonstrated in Chapter 3. In this study, microwave hyperthermia is performed in a realistic environment rather than over-simplified scenarios. In the recommended technique, electromagnetic focusing on patient-specific breast models concentrates the power at the tumour position while successfully keeping the power levels at other positions (healthy tissue) at minimum values. Several patient-specific breast models ranging from fatty tissue to highly dense tissue are used to investigate the effect of breast anatomy on the proposed focusing technique.ii Chapter 4 introduces an improved hyperthermia approach for breast cancer treatment, overcoming the limitations of previously analysed techniques. In this appro...

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Battling cancer: the latest on microwave hyperthermia

Cited by 14 publications

References 6 publications

Generalised method of current excitation reconstruction from near‐field data of planar, cylindrical and spherical antenna arrays

Generalised method of current excitation reconstruction from near‐field data of planar, cylindrical and spherical antenna arrays

Thermosensitive Magnetic Nanoparticles for Self-Controlled Hyperthermia Cancer Treatment

Focusing microwave hyperthermia in realistic environment for breast cancer treatment

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