Bayesian Analysis for Estimation of Genetic Parameters of Calving Ease and Stillbirth for Canadian Holsteins

Luo, Michael; Boêttcher, P.; Dekkers, Jack C. M.; Schaeffer, L.R.

doi:10.3168/jds.s0022-0302(99)75416-0

Cited by 42 publications

(62 citation statements)

References 13 publications

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“…Qanbari et al (2011) suggested that this selection signature is the outcome of strong and recent selective pressure because of the long run of homozygosity observed in this region. This SNP ss86324977 was also shown to be associated with perinatal mortality in the present study thereby substantiating the known genetic association between both traits (Luo et al,1999); the allele substitution effect for the A allele of this SNP was positive for both direct calving difficulty and perinatal mortality. This suggests this genomic region harbours either a gene with pleiotrophic effects on both traits or harbours two or more linked (i.e.…”

Section: Chromosome 18supporting

confidence: 86%

“…ss86324977), whereas others are novel previously unreported associations but have been reported to be associated with growth, skeletal development, birth weight and stature (Cole et al, 2009;McClure et al, 2010;Meyers et al, 2010). QTL regions that were solely associated with one trait were also identified facilitating direct genomic selection for these regions thereby possibly aiding in resolving known genetic antagonisms between the calving performance traits (Luo et al, 1999;Steinbock et al, 2003). However, caution has to be taken when interpreting these QTL regions, as the power of detecting QTLs associated with perinatal mortality in comparison with the other traits was reduced because of the lower quantity of records.…”

Section: Discussionmentioning

confidence: 96%

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Genome-wide association study for calving traits in Holstein–Friesian dairy cattle

Purfield

Bradley

Kearney

et al. 2014

Animal

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Dystocia and perinatal mortality are quantitative traits that significantly impact animal productivity and welfare. Their economic importance is reflected by their inclusion in the national breeding goals of many cattle populations. The genetic architecture that influences these traits, however, has still yet to be thoroughly defined. Regions of the bovine genome associated with calving difficulty (direct and maternal) and perinatal mortality were detected in this study using a Bayesian approach with 43 204 single nucleotide polymorphisms (SNPs) on up to 1970 Holstein-Friesian bulls. Several SNPs on chromosomes 5, 6, 11, 12, 17,18 and 28 were detected to be strongly associated with these calving performance traits. Novel genomic regions with previously reported associations with growth, stature, birth weight and bone morphology were identified in the present study as being associated with the three calving performance traits. Morphological abnormalities are a known contributor to perinatal mortality and the most significantly associated SNP for perinatal mortality in the present study was located in a region in linkage disequilibrium with the gene SLC26A7. This gene, SLC26A7, has similarities and colocalises with SLC4A2, which has previously been associated with osteoporosis and mortality in cattle populations. The HHIP gene that is known to be associated with stature in humans was strongly associated with direct calving difficulty in the present study; large calves are known to, on average, have a greater likelihood of dystocia. A stemloop microRNA, bta-mir-1256, on chromosome 12, involved in post-transcriptional regulation of gene expression was associated with maternal calving difficulty. Previously reported quantitative trait loci associated with calving performance traits in other populations were again identified in this study; with one genomic region on chromosome 18 supporting very strong evidence of an underlying causative mutation and accounting for 2.1% of the genetic variation in direct calving difficulty. Overlapping genomic regions associated with one or more of the calving traits were also detected substantiating the known genetic covariances existing between these traits. Moreover, some genomic regions were only associated with one of the calving traits implying the selective genomic breeding programs exploiting these regions could help resolve genetic antagonisms.Keywords: dystocia, mortality, calving difficulty, genomic, quantitative trait loci ImplicationsThis study contributes to the understanding of the underlying genetic architecture and aetiology of dystocia and perinatal mortality both of which are quantitative traits that have a significant economic farm impact. Moreover, the detection of quantitative trait loci associated with only one calving trait can help resolve genetic antagonisms if targeted in genomic breeding programs -for example, selecting for decreased calving difficulty without impacting maternal calving difficulty.

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Section: Chromosome 18supporting

confidence: 86%

Section: Discussionmentioning

confidence: 96%

Genome-wide association study for calving traits in Holstein–Friesian dairy cattle

Purfield

Bradley

Kearney

et al. 2014

Animal

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“…The results of direct and maternal heritabilities for stillbirth and calving ease in this study were lower than the results from other studies ranging from 0.07 to 0.10 for direct stillbirth, 0.05 to 0.13 for direct calving ease, 0.06 to 0.13 for maternal stillbirth and 0.05 to 0.06 for maternal calving ease (LUO et al 1999, AMIN et al 2000, HANSEN et al 2004, HERINGSTAD et al 2007. Lower heritabilities for calving ease in cows (0.017 direct, 0.014 maternal) were however found by CUE et al (1990).…”

Section: Discussioncontrasting

confidence: 55%

“…However, in this study we followed the linear model applied in the Austrian-German routine breeding value estimation. The genetic correlation between direct and maternal effects of stillbirth and calving ease were found to be negative like in other studies (LUO et al 1999, FÜRST and FÜRST-WALTL 2006, HERINGSTAD et al 2007, LÓPEZ DE MATURANA et al 2007. Genetic correlations between direct and maternal effect of gestation length (0.002-0.063) were lower than results found in earlier studies (PHILIPSSON 1976, NADARAJAH et al 1989, HANSEN et al 2004.…”

Section: Discussioncontrasting

confidence: 55%

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Genetic parameters for calving ease, gestation length and stillbirth in three endangered Austrian blond cattle breeds

2009

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Genetic parameters were estimated for stillbirth, calving ease and gestation length in three endangered Austrian blond cattle breeds, Carinthian Blond, Murboden and Waldviertel Blond. REML analysis based on an animal model including direct and maternal genetic effects was applied. Direct heritability estimates for calving ease, stillbirth and gestation length varied from 0.003 to 0.111, 0.006 to 0.044 and 0.235 to 0.512, respectively, while maternal heritabilities ranged from 0.001 to 0.007 for calving ease, 0.005 to 0.014 for stillbirth, and 0.002 to 0.063 for gestation length. All pairwise genetic correlations for direct traits were generally moderate to high except for stillbirth-calving ease (−0.077, Carinthian Blond). The genetic correlations of all pairs of the 3 direct traits were positive for Murboden (0.520 to 0.700) and Waldviertel Blond (0.253 to 0.707) while negative genetic correlations were detected for Carinthian Blond (−0.077 to −0.943). Close positive genetic correlations were found between direct stillbirth and calving ease of Murboden (0.700) and between direct calving ease and gestation length of Waldviertel Blond (0.707), while a close negative genetic correlation was found between direct calving ease and gestation length of Carinthian Blond (−0.943). Keywords

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Confirming QTL for calving and fertility traits on bovine chromosomes 7 and 10 in German Holsteins

2010

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Bayesian Analysis for Estimation of Genetic Parameters of Calving Ease and Stillbirth for Canadian Holsteins

Cited by 42 publications

References 13 publications

Genome-wide association study for calving traits in Holstein–Friesian dairy cattle

Genome-wide association study for calving traits in Holstein–Friesian dairy cattle

Genetic parameters for calving ease, gestation length and stillbirth in three endangered Austrian blond cattle breeds

Confirming QTL for calving and fertility traits on bovine chromosomes 7 and 10 in German Holsteins

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