2021
DOI: 10.48550/arxiv.2108.05127
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Bayesian local exchangeability design for phase II basket trials

Yilin Liu,
Michael Kane,
Denise Esserman
et al.

Abstract: We propose an information borrowing strategy for the design and monitoring of phase II basket trials based on the local multisource exchangeability assumption between baskets (disease types). We construct a flexible statistical design using the proposed strategy. Our approach partitions potentially heterogeneous baskets into non-exchangeable blocks. Information borrowing is only allowed to occur locally, i.e., among similar baskets within the same block. The amount of borrowing is determined by between-basket … Show more

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