The prediction of possible future incidents or accidents and the efficiency assessment of the Occupational Safety and Health (OSH) interventions are essential for the effective protection of healthcare workers, as the occupational risks in their workplace are multiple and diverse. Machine learning algorithms have been utilized for classifying post-incident and post-accident data into the following 5 classes of events: Needlestick/Cut, Falling, Incident, Accident, and Safety. 476 event reports from Metaxa Cancer Hospital (Greece), during 2014-2019, were used to train the machine learning models. The developed models showed high predictive performance, with area under the curve range 0.950-0.990 and average accuracy of 93% on the 10-fold cross set, compared to the safety engineer’s study reports. The proposed DSS model can contribute to the prediction of incidents or accidents and efficiency evaluation of OSH interventions.