Bayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: a nationwide study during 1985–2015

Konstantinoudis, Garyfallos; Schuhmacher, Dominic; Ammann, Roland A.; Diesch, Tamara; Kuehni, Claudia E.; Spycher, Ben D.

doi:10.1186/s12942-020-00211-7

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…Updated epidemiological data on the burden of brain and CNS cancers is thus required. However, there are few reports on the epidemiology of brain and CNS cancers in all age groups [ 14 – 16 ]. Some studies have focused only on the incidence and mortality of brain and CNS tumors in children, while ignoring incidence and mortality in elderly patients.…”

Section: Introductionmentioning

confidence: 99%

Burden and trends of brain and central nervous system cancer from 1990 to 2019 at the global, regional, and country levels

Yang¹,

Zhang²,

Gao³

et al. 2022

Arch Public Health

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Background Regularly updated epidemiological data on the burden of brain and central nervous system (CNS) cancers are important in the prioritization of research and the allocation of resources. This study aimed to investigate incidence, mortality, disability, and trends in brain and CNS cancers between 1990 and 2019. Methods Epidemiological data, including the cancer incidence, mortality, disability-adjusted life years(DALYs), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALY rate (per 100,000 population) stratified by region, country, sex, and age group were retrieved and extracted using the Global Health Data Exchange (GHDx) query tool. Results In 2019, there were 347,992(262,084–388,896) global cases of brain and CNS cancers, which showed a significant increase (94.35%) from the period between 1990 to 2019. The global ASIR in 2019 was 4.34 (3.27–4.86) per 100, 000 population, which showed an increasing trend for the years 1990–2019 (13.82% [-27.27–32.83]). In 2019, there were 246,253 (185,642–270,930) global deaths caused by brain and CNS cancers, which showed a significant increase (76.36%) during the study period. The global ASMR in 2019 was 3.05(2.29–3.36) per 100, 000 population, which did not change significantly over the study period (-1.19% [-36.79–13.86]). In 2019, there were 8,659,871 DALYs, which was a 109.04% increase compared with 1990. Similarly, during 1990–2019, the age-standardized DALY rate decreased by 10.39%. Additionally, 76.60% of the incident cases, 72.98% of the deaths, and 65.16% of the DALYs due to brain and CNS cancers occurred in the high-income and upper-middle-income regions. Conclusions In conclusion, brain and CNS cancers remain a major public health burden, particularly in high-income regions. The global incidence, deaths, and DALYs of brain and CNS cancers were shown to have increased significantly from 1990 to 2019. The global ASIR kept rising steadily, while the ASMR and age-standardized DALY rate declined over the past three decades. Supplementary Information The online version contains supplementary material available at 10.1186/s13690-022-00965-5.

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Section: Introductionmentioning

confidence: 99%

Burden and trends of brain and central nervous system cancer from 1990 to 2019 at the global, regional, and country levels

Yang¹,

Zhang²,

Gao³

et al. 2022

Arch Public Health

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“…There appears to be a positive association between the risk of brain tumours and exposure to pesticides [ 13 , 14 ]. However, the data are not always consistent and replicable.…”

Section: Causes/risk Factorsmentioning

confidence: 99%

Central nervous system tumours in neonates: what should the neonatologist know?

Toniutti,

Sasso,

Carai

et al. 2024

Eur J Pediatr

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Central nervous system (CNS) tumours in neonates are relatively rare and present differently when compared with those occurring later in childhood in terms of aetiology, clinical features, location, histology and prognosis. The clinical presentation is extremely variable. Even if the most frequent clinical sign is a macrocephaly, there are many other non-specific symptoms associated. The prognosis is usually poor with overall survival of less than 30%. Surgery continues to be the primary treatment for neonatal CNS tumours, aiming for a gross total resection, directly correlated with prognosis and the overall outcome. The chemotherapy is the only adjuvant therapy whereas the radiotherapy is avoided under three years of age because of the severe sequelae. Hence the importance of molecular characterization of these neoplasms in order to improve the accuracy of the diagnosis and identify new therapeutic targets. The aim of this review is to describe the main characteristics of these tumours and the recent advances in their treatment in order to recognize these pathologies in the prenatal period and create a multidisciplinary team providing the best possible treatment while minimising the risk of long-term complications. Neonatologists play a key role in the early detection, diagnostic evaluation, management and supportive care of these neonates. Conclusion: The aim of this review is to describe the main characteristics of these tumours and the recent advances in their treatment in order to ensure the essential knowledge that will help the neonatologist identify them and create a multidisciplinary team providing the best possible treatment while minimising the risk of long-term complications. What is Known:• Neonatal CNS tumours are relatively rare and their early identification is important to identify the best diagnostic-therapeutic management.• Surgery is the main treatment of neonatal CNS tumours. The extent of surgical resection directly correlates with prognosis and outcome. What is New:• Predisposing conditions such as Cancer Predisposition Syndromes must be considered.• Targeted drugs and other therapeutic strategies can be identified through molecular characterization

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“…Swiss SEP was included to adjust for any influence of socio-economic factors. In addition, we adjusted for (5) years of existence of a general cantonal cancer registry to account for potential differences in registration coverage (Konstantinoudis et al 2020). While the SCCR has nationwide coverage, general cantonal registries were consulted, where they existed, to identify any missed cases.…”

Section: Potential Confoundersmentioning

confidence: 99%

Childhood cancer and residential proximity to petrol stations: a nationwide registry-based case–control study in Switzerland and an updated meta-analysis

Mazzei

Konstantinoudis

Kreis

et al. 2021

Int Arch Occup Environ Health

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Purpose Benzene is a known carcinogen for adult leukemia. Exposure to benzene through parental occupation and the use of household products has been associated with childhood leukemia (CL). Ambient benzene has also been associated with CL and central nervous system (CNS) tumors. We aimed to investigate whether the higher ambient levels of benzene in proximity of petrol stations are associated with a greater risk of childhood cancers, leukemia, and CNS tumors. Methods We identified children diagnosed with cancer at age 0–15 years during 1985–2015 from the Swiss Childhood Cancer Registry and selected 10 age and sex-matched controls per case from national censuses. We calculated the distance from children’s home to the nearest petrol station using precise geocodes. We estimated odds ratios using conditional logistic regression adjusting for ambient levels of NO2, distance to highways, level of urbanization, and presence of a cantonal cancer registry. In addition, we ran a meta-analysis pooling current results for CL with those of previous studies. Results We identified 6129 cases, of which 1880 were leukemias and 1290 CNS tumors. 24 cases lived within 50 m from a petrol station. The adjusted odds ratio of a cancer diagnosis for children thus exposed compared to unexposed children (> 500 m) was 1.29 (0.84–1.98) for all cancers combined, 1.08 (0.46–2.51) for leukemia, and 1.30 (0.51–3.35) for CNS tumors. During 2000–2015, when exposure assessment was more precise, the adjusted odds ratio for any cancer diagnosis was 1.77 (1.05–2.98). The summary relative risk estimate for CL in the meta-analysis including four studies was 2.01 (1.25–3.22). Conclusions Our study provides weak support for an increased risk of childhood cancers among children living close to petrol stations. A meta-analysis including our study suggests an increased risk for CL.

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Bayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: a nationwide study during 1985–2015

Cited by 8 publications

References 48 publications

Burden and trends of brain and central nervous system cancer from 1990 to 2019 at the global, regional, and country levels

Burden and trends of brain and central nervous system cancer from 1990 to 2019 at the global, regional, and country levels

Central nervous system tumours in neonates: what should the neonatologist know?

Childhood cancer and residential proximity to petrol stations: a nationwide registry-based case–control study in Switzerland and an updated meta-analysis

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