2024
DOI: 10.1101/2024.07.17.603892
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BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

Guozhu Ning,
Yu Lin,
Haixia Ma
et al.

Abstract: Breast carcinoma amplified sequence 2 (BCAS2), a core component of the hPrP19 complex, plays an important role in RNA-splicing and DNA damage. However, whether BCAS2 has other functions within the nucleus remains largely unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation of Wnt/β-catenin signal, which is required for hematopoietic progenitor differentiation, is significantly decreased upon depletion ofbcas2in zebrafish embryos and mouse emb… Show more

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