Bcl-2–associated athanogene 3 protects the heart from ischemia/reperfusion injury

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress

“…Conversely, manipulating the pathways regulated by BAG3 may also protect against cardiac injury. A recent study supporting this hypothesis reported that exogenous BAG3 could protect against cardiac injury from hypoxia-ischemia in mice (48).…”

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

“…BAG3 is a member of an evolutionarily conserved family of molecular co-chaperones (20) that interact with chaperones of the HSP family, including HSP70, to modulate their function (18,(21)(22)(23). BAG3 is prominently expressed in cardiac and skeletal muscle tissues (24).…”

Liraglutide-induced reduction of myocardial ischemiareperfusion injury in rats via ERK1/2 signaling pathway

“…In the mitochondrial membrane, Bcl-2 and Bax are involved in the control of mitochondrial permeability to cytochrome c. It is known that the mitochondrial permeability of cytochrome c is reduced when Bcl-2 molecules form homodimers, but is increased when Bax forms heterodimers with Bcl-2 [13,14]. Thus the Bcl-2/Bax ratio is a critical factor that regulates mitochondrial apoptosis: decreased the expression of Bcl-2 and increased the expression of Bax result in increases in mitochondrial membrane permeability to cytochrome c, thereby initiating apoptosis through caspase-8/caspase-3 [15,16].…”