bcl-2 EXPRESSION IN PLEURAL AND EXTRAPLEURAL SOLITARY FIBROUS TUMOURS

Chilosi, Marco; Facchetti, Fabio; Tos, Angelo Paolo Dei; Lestani, Maurizio; Morassi, Maria Laura; Martignoni, Guido; Sorio, Claudio; Benedetti, A.; Morelli, Luca; Doglioni, Claudio; Barberis, Massimo; Menestrina, Fabio; Viale, Giuseppe

doi:10.1002/(sici)1096-9896(199704)181:4<362::aid-path764>3.0.co;2-y

Cited by 164 publications

(53 citation statements)

References 29 publications

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“…A recent study has investigated CDK6 expression in both normal and (d) and (e) show increased staining for CDK6 compared to the CD19 negative populations. In (f) and (g) there is no comparable increase in CDK6 expression neoplastic lymphoid tissues using immunocytochemistry and¯ow cytometry (Chilosi et al, 1998). CDK6 was strongly expressed in both normal cortical thymocytes and T cell acute lymphoblastic leukemia or lymphoblastic lymphoma.…”

Section: Discussionmentioning

confidence: 93%

Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

et al. 1999

Oncogene

130

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The increased or inappropriate expression of genes with oncogenic properties through speci®c chromosome translocations is an important event in the pathogenesis of Bcell lymphoproliferative diseases. Recent studies have found deletions or translocations of chromosome 7q to be the most common cytogenetic abnormality observed in SLVL, a leukemic variant of SMZL, with the q21 ± q22 region being most frequently a ected. In three patients with translocations between chromosomes 2 and 7, the cloning of the breakpoints at 7q21 revealed that each was located within a small region of DNA 3.6 kb upstream of the transcription start site of cyclin dependent kinase 6 (CDK6). In each case the translocation event was consistent with aberrant VJ recombination between the immunoglobulin light chain region (Ig kappa) on chromosome 2p12 and DNA sequences at 7q21, resembling the heptamer recombination site. The t(7;21) breakpoint in an additional patient with splenic marginal zone lymphoma (SMZL), resided 66 kb telomeric to the t(2;7) breakpoints juxtaposing CDK6 to an uncharacterized transcript. In two of the SLVL patient samples, the CDK6 protein was found to be markedly over expressed. These results suggest that dysregulation of CDK6 gene expression contributes to the pathogenesis of SLVL and SMZL.

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Section: Discussionmentioning

confidence: 93%

Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

et al. 1999

Oncogene

130

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“…47 Another marker that can be useful in this differential diagnosis is bcl-2, which has been reported to be expressed in 79 to 100% of synovial sarcomas, but in only 0 to 10% of mesotheliomas. [48][49][50][51] It should be mentioned, however, that TLE1, a marker that has an important role in the Wnt pathway and that has been shown to be a highly sensitive and specific immunohistochemical marker for synovial sarcoma, 52 was found in a recent study to be variably expressed in about 70% of mesotheliomas regardless of their histomorphologic subtype, thus demonstrating that immunostaining for this marker has little or no value in discriminating between synovial sarcomas and mesotheliomas. 53 Additionally, the demonstration of the distinctive t(x;18)(p11;q11) translocation that is reportedly present in nearly all synovial sarcomas can help to establish the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Mesotheliomas with small cell features: report of eight cases

Ordóñez

2012

Modern Pathology

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Mesotheliomas with small cell morphology are rare and only one study of such cases has been published. As a result of their rare occurrence, some investigators have cast doubt on the existence of such a histologic variant of mesothelioma. This investigator reports a series of eight cases of epithelioid mesothelioma with small cell features, all of which originated in the pleura. Seven of the patients were men and one was a woman. Four patients had a history of asbestos exposure. Histologically, four of the mesotheliomas were epithelioid and four biphasic. The proportion of small cells seen in these cases constituted 80 to 100% of the tumor included in the biopsy material and 15 to 20% of the tumor present in the pneumonectomy specimens. Immunoreactivity for calretinin, keratin 5/6, keratin 7, pan-keratin, WT1, podoplanin, and mesothelin was seen in all cases tested for these markers. All of the cases were negative for MOC-31, Ber-EP4, CEA, CD15, TAG-72, TTF-1, chromogranin A, synaptophysin, CD99, and desmin. The mean survival of the six patients for whom this information was available was 8.2 months. It is important for pathologists to be aware that mesotheliomas can present small cell features and, because of this, they can be confused with other malignancies that can exhibit similar morphology. The value of immunohistochemistry in the differential diagnosis of these tumors is discussed.

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“…Mitotic activity varies from 0 to 50 per 10 hpf, and some cases have necrosis or hemorrhage. Immunohistochemically, strong and diffuse CD34 and bcl-2 expression is a feature of this tumor type [2,53,54]. Indeed, a CD34-negative tumor in an extrapleural location should probably not be diagnosed as solitary fibrous tumor unless other evidence is compelling [44].…”

Section: Solitary Fibrous Tumormentioning

confidence: 98%

Low-grade Sarcomas with CD34-Positive Fibroblasts and Low-Grade Myofibroblastic Sarcomas

Fisher

2004

Ultrastructural Pathology

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bcl-2 EXPRESSION IN PLEURAL AND EXTRAPLEURAL SOLITARY FIBROUS TUMOURS

Cited by 164 publications

References 29 publications

Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

Mesotheliomas with small cell features: report of eight cases

Low-grade Sarcomas with CD34-Positive Fibroblasts and Low-Grade Myofibroblastic Sarcomas

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