Bcl-2 Oncoprotein Positivity and High MIB-1 (Ki-67) Proliferative Rate Are Independent Predictive Markers for Recurrence in Prostate Carcinoma

Keshgegian, Albert A.; Johnston, Elaine; Cnaan, Avital

doi:10.1093/ajcp/110.4.443

Cited by 89 publications

(59 citation statements)

References 15 publications

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“…Similar results have also been reported for esophageal, cervical and head, and neck carcinomas and colorectal adenocarcinomas (36,37,38). In Hodgkin's lymphoma, association of prostate carcinomas, testicular carcinomas, and acute myelogenous leukemia has been described to have opposite effects, with higher expression values being associated with a dismal prognosis (39,40,41,42). The antiapoptotic role of BCL2 has been well characterized but the exact mechanism by which BCL2 might exert its protective effect on some kinds of cancers is still unclear.…”

Section: Discussionsupporting

confidence: 73%

Expression profile of apoptosis-related genes in childhood adrenocortical tumors: low level of expression of BCL2 and TNF genes suggests a poor prognosis

Lorea

Moreno

Borges

et al. 2012

European Journal of Endocrinology

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Background: Impaired apoptosis has been implicated in the development of childhood adrenocortical tumors (ACT), although the expression of apoptosis-related gene expression in such tumors has not been reported. Methods: The mRNA expression levels of the genes CASP3, CASP8, CASP9, FAS, TNF, NFKB, and BCL2 were analyzed by quantitative real-time PCR in consecutive tumor samples obtained at diagnosis from 60 children with a diagnosis of ACT and in 11 non-neoplastic adrenal samples. BCL2 and TNF protein expression was analyzed by immunohistochemistry. Results: A significant association was observed between tumor size R100 g and lower expression levels of the BCL2 (PZ0.03) and TNF (PZ0.05) genes; between stage IV and lower expression levels of CASP3 (PZ0.008), CASP9 (PZ0.02), BCL2 (PZ0.002), TNF (PZ0.05), and NFKB (PZ0.03); Weiss score R3 and lower expression of TNF (PZ0.01); unfavorable event and higher expression values of CASP9 (PZ0.01) and lower values of TNF (PZ0.02); and death and lower expression of BCL2 (PZ0.04). Underexpression of TNF was associated with lower event-free survival in uni-and multivariate analyses (P!0.01). Similar results were observed when patients with Weiss score !3 were excluded. Conclusion: This study supports the participation of apoptosis-related genes in the biology and prognosis of childhood ACT and suggests the complex role of these genes in the pathogenesis of this tumor.

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Section: Discussionsupporting

confidence: 73%

Expression profile of apoptosis-related genes in childhood adrenocortical tumors: low level of expression of BCL2 and TNF genes suggests a poor prognosis

Lorea

Moreno

Borges

et al. 2012

European Journal of Endocrinology

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“…Accordingly in those studies Increased Bcl-2 expression is associated to favorable outcome. While its high expression is associated with poor survival in B-cell chronic lymphocytic leukemia (CLL), prostate cancer and urinary tract transitional cell cancer (Faderal et al, 2002;Keshgegian et al, 1998;Stackhouse et al, 1999). Rostamizadeh et al demonstrated the higher expression levels of the Bcl-2 gene in tumor samples compared with marginal samples, however, this was not a significant difference (p>0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Which of the dual functions' predominates seem to be tissue specific; for example, increased Bcl-2 expression is associated with unfavorable outcome in B-cell chronic lymphocytic leukemia (CLL) and prostate cancer (Ofner et al, 1995;) whereas its expression is related to increased survival in colorectal and breast carcinoma (Keshgegian et al, 1998;Faderl et al, 2002). apoptosis markers, in particular Bcl-2 and Bax expression, are receiving much attention for their relationship with the cellular response to genotoxic damage in experimental tumors (Chipuk et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Low Expression of the bcl2 Gene in Gastric Adenocarcinomas in Mazandaran Province of Iran

Mirmajidi¹,

Ataee²,

Barzegar³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Gastric cancer accounts for about 8% of the total cancer cases and 10% of total cancer deaths worldwide. It is the second lethal cancer after esophageal cancer and is considered the fourth most common cancer in north and northwest Iran. The bcl2 family has a key role in the regulation of apoptosis and change in its expression can contribute to cancer. This study initially scheduled to determine the expression of bcl2 gene in tissue samples of adenocarcinoma cancer patients. Materials and Methods: A total of 10 samples of gastric adenocarcinoma and 10 of normal tissues from Sari hospital were selected and after DNA extraction from tissues, bcl2 gene expression assayed by real-time PCR. Results: Our results demonstrated higher expression of the bcl2 gene in control compared with cancer and marginal cancer tissues. Conclusions: On one hand BCL2 plays an important role as an oncogene to inhibit apoptosis; on the other hand, it can initiate cell cycle arrest at G0 stage. Our observed association between its expression and patient survival is quite conflicting and may be tissue-specific. The data suggest expression both tumoural and non-tumoral(marginal) groups have lowered expression than controls (P>0.05). Due to the low number of samples we could not examine the relationship with clinicopathological features. However, bcl-2 expression may be important for prognostic outcome or a useful target for therapeutic intervention.

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“…19,[26][27][28][29][30][31][32][33][34][35][36] Overexpression of the BCL-2 gene may predispose dysplastic epithelium to genetic instability, which may lead to neoplasia and the invasive phenotype. To our knowledge, there are no published reports on the relationship between genetic alterations in the antiapoptotic-related gene, namely BCL-2, and prostate cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

Kidd

Coulibaly

Templeton

et al. 2006

Prostate Cancer Prostatic Dis

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Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant À938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

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Bcl-2 Oncoprotein Positivity and High MIB-1 (Ki-67) Proliferative Rate Are Independent Predictive Markers for Recurrence in Prostate Carcinoma

Abstract: A b s t r a c t

Cited by 89 publications

References 15 publications

Expression profile of apoptosis-related genes in childhood adrenocortical tumors: low level of expression of BCL2 and TNF genes suggests a poor prognosis

Expression profile of apoptosis-related genes in childhood adrenocortical tumors: low level of expression of BCL2 and TNF genes suggests a poor prognosis

Low Expression of the bcl2 Gene in Gastric Adenocarcinomas in Mazandaran Province of Iran

Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

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