Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation

Huang, Mo-Fan; Shoemaker, Rachel; Lee, Dung‐Fang

doi:10.1089/cell.2022.0128

Cited by 1 publication

(1 citation statement)

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“…Cell reprogramming involves the modification of gene expression within a cell, transforming it from one cell type to another; this alteration in cell differentiation lineage can, thereby, affect the cell's ability to differentiate (Huang et al 2022 ). Prior studies have established that cell reprogramming can transform TERC haploid cells into cells of other lineages; for example, mature somatic cells can be transformed into various cells, such as mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs).…”

Section: Introductionmentioning

confidence: 99%

TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia

Tang

Wang

et al. 2023

Mol Med

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The telomerase RNA component (TERC) gene plays an important role in telomerase-dependent extension and maintenance of the telomeres. In the event of TERC haploinsufficiency, telomere length is often affected; this, in turn, can result in the development of progeria-related diseases such as aplastic anemia (AA) and congenital keratosis. Cell reprogramming can reverse the differentiation process and can, therefore, transform cells into pluripotent stem cells with stronger differentiation and self-renewal abilities; further, cell reprograming can also extend the telomere length of these cells, which may be crucial in the diagnosis and treatment of telomere depletion diseases such as AA. In this study, we summarized the effects of TERC haploid cell reprogramming on telomere length and the correlation between this alteration and the pathogenesis of AA; by investigating the role of cell reprogramming in AA, we aimed to identify novel diagnostic indicators and therapeutic strategies for patients with AA.

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Section: Introductionmentioning

confidence: 99%