BCLC 2022 Update: Still a Long Way to Prove the Efficacy of External Beam Radiation Therapy

Sharma, Deepti; Kamal, Rose; Thaper, Deepak

doi:10.1055/s-0042-1758523

Cited by 1 publication

(1 citation statement)

References 12 publications

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“…However, in the intermediate stages and selected cases of advanced-stage HCC, a spectrum of strategies comes into play, such as TACE, trans-arterial radioembolization (TARE), radiofrequency ablation (RFA), microwave ablation (MWA), and SBRT [ 24 , 25 , 26 ]. The advent of SBRT and proton therapy, in particular, has enhanced the precision and effectiveness of radiation delivery, minimizing unintentional harm to surrounding healthy tissues and offering a testament to the ongoing innovation within EBRT modalities such as Intensity-Modulated Radiation Therapy (IMRT) and Image-Guided Radiation Therapy (IGRT) [ 27 , 28 ].…”

Section: Overview Of Current Management Of Hcc: Focus On Ici and Radi...mentioning

confidence: 99%

Immunotherapy and Radiation Therapy Combinatorial Approaches in Hepatocellular Carcinoma

Tojjari,

Yu,

Saeed

2024

Cancers

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Hepatocellular carcinoma (HCC), a prevalent and often fatal liver cancer, presents significant treatment challenges, especially in its advanced stages. This article delves into the promising approach of combining immunotherapy, particularly immune checkpoint inhibitors, with radiation therapy, a cornerstone of HCC management. Our review synthesizes current preclinical and clinical research, highlighting the potential synergistic effects of this combinational treatment. Emerging evidence suggests that this synergy enhances tumor control and improves patient survival rates. The combination leverages the localized, tumor-targeting ability of radiation therapy and the systemic, immune-boosting effects of immunotherapy, potentially overcoming the limitations inherent in each treatment modality when used separately. This integrative approach is especially promising in addressing the complex tumor microenvironment of HCC. However, the treatment landscape is nuanced, with challenges such as patient-specific response variability and potential resistance to therapies. Future research directions should focus on refining these combination strategies, tailoring them to individual patient profiles, and understanding the underlying mechanisms that govern the interaction between immunotherapy and radiation therapy. Such advancements could significantly improve HCC management, setting new standards for patient care and treatment efficacy.

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Section: Overview Of Current Management Of Hcc: Focus On Ici and Radi...mentioning

confidence: 99%

Immunotherapy and Radiation Therapy Combinatorial Approaches in Hepatocellular Carcinoma

Tojjari,

Yu,

Saeed

2024

Cancers

View full text Add to dashboard Cite

show abstract

BCLC 2022 Update: Still a Long Way to Prove the Efficacy of External Beam Radiation Therapy

Cited by 1 publication

References 12 publications

Immunotherapy and Radiation Therapy Combinatorial Approaches in Hepatocellular Carcinoma

Immunotherapy and Radiation Therapy Combinatorial Approaches in Hepatocellular Carcinoma

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