2019
DOI: 10.1038/s41375-019-0540-7
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BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications

Abstract: Objective: The purpose of these studies was to develop and characterize B-cell Maturation Antigen (BCMA)-specific peptide encapsulated nanoparticle formulations to efficiently evoke BCMA-specific CD8 + cytotoxic T lymphocytes (CTL) with poly-functional immune activities against multiple myeloma (MM). Findings: Heteroclitic BCMA 72-80 [YLMFLLRKI] peptide encapsulated liposome or poly(lactic-co-glycolic acid) (PLGA) nanoparticles displayed uniform size distribution and increased peptide delivery to human dendrit… Show more

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Cited by 42 publications
(38 citation statements)
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“…We identified P(BCMA) B*18 as a highly immunogenic naturally presented epitope capable of inducing potent and multifunctional cytotoxic T-cell responses. This is in line with recent data reporting on the high immunogenicity of computationally predicted HLA*02-restricted T-cell epitopes derived from the extracellular surface domain of BCMA 32,33 . Our mass spectrometric approach further allowed us to validate P(BCMA) B*18 additionally as a target for CLL, for which plasma BCMA-levels were described as a prognostic factor 34 .…”
Section: Discussionsupporting
confidence: 92%
“…We identified P(BCMA) B*18 as a highly immunogenic naturally presented epitope capable of inducing potent and multifunctional cytotoxic T-cell responses. This is in line with recent data reporting on the high immunogenicity of computationally predicted HLA*02-restricted T-cell epitopes derived from the extracellular surface domain of BCMA 32,33 . Our mass spectrometric approach further allowed us to validate P(BCMA) B*18 additionally as a target for CLL, for which plasma BCMA-levels were described as a prognostic factor 34 .…”
Section: Discussionsupporting
confidence: 92%
“…At present, the main specific antigens of MM that show potential in the targeting therapy of MM include BCMA [ 90 ], HM1.24 [ 91 ], MUC-1 [ 92 ], MAGE-C1 [ 93 ], B7-H1 [ 94 ] and HSP [ 95 ]. To date, there has been no investigation reporting the application of DC-EXs in an anti-myeloma vaccine.…”
Section: The Roles Of Exosomes In Cancer Vaccinesmentioning
confidence: 99%
“…Possesses the influencing factors to immune responses and induces a systemic antigen specific immune response. [ 76 ] Poly(propylene) sulfide (PPS) CD4+ and CD8+ T-cell inducer, passive targeting of the lymph node. In the presence of ipsilateral, the PPS aims at TDLNs.…”
Section: Specific Delivery Of Immunotherapies From the Nanoparticle-imentioning
confidence: 99%