BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis

Harrisberger, Fabienne; Smieskova, Renata; Schmidt, André; Lenz, Claudia; Walter, Anna; Wittfeld, Katharina; Grabe, H. J.; Lang, Undine E.; Fusar‐Poli, Paolo; Borgwardt, Stefan

doi:10.1016/j.neubiorev.2015.04.017

Cited by 124 publications

(82 citation statements)

References 106 publications

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“…This polymorphism affects the activity-dependent secretion of BDNF (Egan et al 2003). Although at first, a negative association between the val66met polymorphism and hippocampal volume has been reported (Frodl et al 2007), this observation was not supported by a meta-analysis that did not evidence any association between hippocampal volume and the val66met genotype in neuropsychiatric patients, perhaps because of the too many different disorders analyzed in this study (Harrisberger et al 2015). Yet again, several other meta-analyses did confirm the association between the val66met polymorphism and an increased susceptibility to mood disorders (Hosang et al 2014; Li et al 2016; Yan et al 2014; Zou et al 2010).…”

Section: Neurotrophins and Other Growth Factorscontrasting

confidence: 57%

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

et al. 2018

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Depression is a major health problem with a high prevalence and a heavy socioeconomic burden in western societies. It is associated with atrophy and impaired functioning of cortico-limbic regions involved in mood and emotion regulation. It has been suggested that alterations in neurotrophins underlie impaired neuroplasticity, which may be causally related to the development and course of depression. Accordingly, mounting evidence suggests that antidepressant treatment may exert its beneficial effects by enhancing trophic signaling on neuronal and synaptic plasticity. However, current antidepressants still show a delayed onset of action, as well as lack of efficacy. Hence, a deeper understanding of the molecular and cellular mechanisms involved in the pathophysiology of depression, as well as in the action of antidepressants, might provide further insight to drive the development of novel fast-acting and more effective therapies. Here, we summarize the current literature on the involvement of neurotrophic factors in the pathophysiology and treatment of depression. Further, we advocate that future development of antidepressants should be based on the neurotrophin theory.

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Section: Neurotrophins and Other Growth Factorscontrasting

confidence: 57%

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

et al. 2018

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“…These observations were confirmed in three meta-analytic reviews (Hajek et al 2012, Kambeitz et al 2012, Molendijk et al 2012. However, the most recent meta-analyses showed no association between Val66Met polymorphism and hippocampal volumes neither in healthy subjects nor clinical groups (Harrisberger et al 2014(Harrisberger et al , 2015. The authors suggest that inconsistency of the results may be related to measuring techniques and sample sizes.…”

Section: Introductionmentioning

confidence: 83%

BDNF gene polymorphisms and haplotypes in relation to cognitive performance in Polish healthy subjects

Wiłkość¹,

Szałkowska²,

Skibińska³

et al. 2016

Acta Neurobiologiae Experimentalis

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The brain derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in the cell survival, axonal and dendritic growth, and synaptic plasticity. BDNF gene polymorphisms, functional Val66Met mainly, were shown to influence human brain structure and cognition.The aim of the study was to assess the relationship between twelve BDNF gene variants and their haplotypes and cognitive performance measured using the Wisconsin Card Sorting Test (WCST), the Trail Making Test (TMT), the Stroop Test which are to a large extent connected with prefrontal cortex activity. Our sample consisted of 460 healthy participants from Polish population. We detected possible association between five BDNF polymorphisms (rs11030101, rs10835210, rs2049046, rs2030324, rs2883187) and TMT_A. Additionally, one haplotype block made from eleven BDNF variants (rs2883187, rs1401635, rs2049046, rs2030324, rs11030101, rs10835210, rs1013402, rs1401635, rs1013402), as significant linkage disequilibrium appeared. We discovered possible relationships of CACCGCGTACG and CACCGCGTACG haplotypes with TMT_A and TMT_B performance respectively. Our results confirmed the involvement of BDNF in the regulation of psychomotor speed, working memory and executive function in healthy subjects measured by a task engaging visuoperceptual abilities.

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“…Rodents have natural inheritance to explore and interact with novel conspecifics versus familiar conspecifics, presumably due to their intact social memory. The social recognition or social memory is measured by the amount of time the subject spend with a novel conspecific versus a familiar conspecific [17][18][19][20]. Thus, in both assays wild type subjects tend to spend more time in the chamber with a novel conspecific.…”

Section: Manifestation and Assessment Of Social Dysfunctions In Animamentioning

confidence: 99%

Hippocampal CA2 Region: A New Player in Social Dysfunctions

Mou¹

2016

J Neurol Neurophysiol

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For social species, normal social cognitive functions are essential for individuals to survive in a social group. Various neuropsychiatric disorders, including schizophrenia, autism and bipolar disorder are characterized by the impairments in social cognition. The hippocampus has been at the forefront of research in learning and memory for several decades. Hippocampal dysfunction contributes to learning and memory impairments as well as a range of social dysfunctions. However, precise contributions of different hippocampal sub-regions to differential aspects of cognitive functions remain unclear. This review first describes several key features of social abnormalities related to neuropsychiatric disorders, and then introduces the behavioral tasks used in animal models to assess each feature. Second, it gives a basic description of CA2 anatomy followed by an overview of its known functions. Third, it highlights a number of recent findings that associate the abnormalities of the hippocampal CA2 area and social dysfunctions in both animal models and human patients.

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BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis

Abstract: This meta-analysis suggests that there is no association between this BDNF polymorphism and hippocampal volumes. For each BDNF genotype, the hippocampal volumes were significantly lower in neuropsychiatric patients than in healthy controls.

Cited by 124 publications

References 106 publications

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

BDNF gene polymorphisms and haplotypes in relation to cognitive performance in Polish healthy subjects

Hippocampal CA2 Region: A New Player in Social Dysfunctions

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