Quantum key distribution (QKD) offers a reliable solution to communication problems that require long-term data security. For its widespread use, however, the rate and reach of QKD systems must be improved. Twin-field (TF) QKD is a step forward toward this direction, with early demonstrations suggesting it can beat the current rate-versus-distance records. A recently introduced variant of TF-QKD is particularly suited for experimental implementation, and has been shown to offer a higher key rate than other variants in the asymptotic regime, where users exchange an infinite number of signals. Here, we extend the security of this protocol to the finite-key regime, showing that it can overcome the fundamental bounds on point-to-point QKD with ~1010 transmitted signals. In many practical regimes of interest, our analysis offers higher key rates than those of alternative variants. Moreover, some of the techniques we develop are applicable to the finite-key analysis of other QKD protocols.