Bee Venom Acupuncture for Neck Pain: A Review of the Korean Literature

Sung, Soo-Hyun; Lee, Hee-Jung; Han, Jieun; Sung, Angela Dongmin; Park, Minjung; Shin, Seung Won; Jeong, Hye In; Jang, Soobin; Lee, Gihyun

doi:10.3390/toxins15020129

Cited by 6 publications

(3 citation statements)

References 55 publications

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“…Its cytotoxic function is prominenced as bee venom can selectively kill cancer cells (Sharkawi et al, 2015; Tu et al, 2008). Besides, a wide range of therapeutic potentials such anti-rheumatoid, anti-inflammatory and anti-aging activities of bee venom have been reported (El-Tedawy et al, 2020; Sung et al, 2023). Although bee venom is well-known to have a strong cytotoxic potential, its cytotoxic specificity regarding the discrimination between anastatic and non-anastatic profiles in cancer and normal cells has not been revealed.…”

Section: Introductionmentioning

confidence: 99%

Anastasis induced by bee venom in normal cells compared to persistent cell death in breast cancer cells

Tetikoglu,

Uzuner,

Celik Uzuner

2024

Preprint

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Anastasis is a phenomenon that has been recently defined as a return from induced apoptosis. Its mechanism has not been clearly elucidated. Anastasis is thought to be involved in the development of drug resistance in cancer cells, however the distinct regulation of anastasis in normal and cancerous cells during anti-cancer therapy has not been discovered. One of the most privileged therapy strategies focuses on the drugs that are selectively cytotoxic in cancer cells but not negatively affect normal cell proliferation. This study for the first time comparatively evaluated the anastatic effect of a common synthetic cytotoxic agent, cisplatin and a natural cytotoxic agent, bee venom. The study showed that bee venom induced anastasis in normal cells (MCF10A, NIH3T3 and ARPE19) but cancer cells (MDA-MB-231 and MCF7) were irreversibly in cell death process. Liver cancer cells (HEPG2) were more resistant to bee venom-induced persistent cell death and tended to recover at higher concentrations compared to breast cancer cells. However, cisplatin induced persistent cell death in both normal and cancerous cells. Besides, selectivity indexes of bee venom in terms of IC50 values were higher than cisplatin. This study indicates that bee venom produces such an effect by selectively inducing anastasis only in normal cells suggesting that bee venom has prominent potential for cancer therapy, in particular for breast cancer, with recovery and maintenance of viability of normal cells.

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Section: Introductionmentioning

confidence: 99%

Anastasis induced by bee venom in normal cells compared to persistent cell death in breast cancer cells

Tetikoglu,

Uzuner,

Celik Uzuner

2024

Preprint

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“…Its cytotoxic function is prominenced as bee venom can selectively kill cancer cells [10,11] . Besides, a wide range of therapeutic potentials such anti-rheumatoid, anti-in ammatory and anti-aging activities of bee venom have been reported [12,13] . Although bee venom is well-known to have a strong cytotoxic potential, its cytotoxic speci city regarding the discrimination between anastatic and non-anastatic pro les in cancer and normal cells has not been revealed.…”

Section: Introductionmentioning

confidence: 99%

Selective Anastasis Induction by Bee Venom in Normal Cells: A Promising Strategy for Breast Cancer Therapy with Minimal Impact on Normal Cell Viability

Tetikoglu,

AKCAN,

UZUNER

et al. 2024

Preprint

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Anastasis is a phenomenon recently described as cellular escape from induced apoptosis. Although its mechanism has not yet been fully elucidated, anastasis is thought to play a role in the development of drug resistance in cancer cells. However, no significant regulation of anastasis has been discovered in normal and cancerous cells during anti-cancer therapy. What is expected from current cancer treatment strategies is the development of drugs that can selectively attack cancer cells without negatively affecting normal cell proliferation. Therefore, this study is the first to evaluate whether bee venom, a natural cytotoxic agent, has similar selectivity in producing an anastatic effect compared to the cytotoxic agent cisplatin. The study showed that bee venom was effective on inducing anastasis in normal cells (MCF10A, NIH3T3 and ARPE19), but on the process of irreversible cell death in breast cancer cells (MDA-MB-231 and MCF7). On the other hand, liver cancer cells (HEPG2) were moderately more resistant to permanent cell death caused by bee venom and tended to recover at higher concentrations compared to breast cancer cells. However, cisplatin treatment caused permanent non-selective cell death in both normal and cancerous cells. In addition, it was determined that the selectivity indices based on IC50 values of bee venom were higher than cisplatin. Taken together, bee venom is effective at selectively inducing anastasis only in normal cells rather than cancer cells; This suggests that bee venom has significant potential in selective cancer therapy, especially breast cancer, by promoting the recovery and maintenance of viability of normal cells.

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“…Regardless of the significant developments in modern medicine, pharmaceuticals resulting from plant and animal species continuously make important contributions to health in terms of the prevention and treatment of numerous diseases [ 1 , 2 , 3 , 4 , 5 ]. Many treatments that are frequently used in Western countries come from Asia, and their popularity is increasing rapidly [ 6 , 7 , 8 , 9 ]. Animal venoms, especially those from insects, have historical usage in scientific research, and are used today as a source of various products and drugs with potential medical applications [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Bee Venom: Composition and Anticancer Properties

Gajski,

Leonova,

Sjakste

2024

Toxins

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Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities. Today, a large number of studies are focused on the antitumor effects of BV, which are mainly attributed to its basic polypeptide melittin (MEL). Previous studies have indicated that BV and its major constituent MEL cause a strong toxic effect on different cancer cells, such as liver, lung, bladder, kidney, prostate, breast, and leukemia cells, while a less pronounced effect was observed in normal non-target cells. Their proposed mechanisms of action, such as the effect on proliferation and growth inhibition, cell cycle alterations, and induction of cell death through several cancer cell death mechanisms, are associated with the activation of phospholipase A2 (PLA2), caspases, and matrix metalloproteinases that destroy cancer cells. Numerous cellular effects of BV and MEL need to be elucidated on the molecular level, while the key issue has to do with the trigger of the apoptotic cascade. Apoptosis could be either a consequence of the plasmatic membrane fenestration or the result of the direct interaction of the BV components with pro-apoptotic and anti-apoptotic factors. The interaction of BV peptides and enzymes with the plasma membrane is a crucial step in the whole process. However, before its possible application as a remedy, it is crucial to identify the correct route of exposure and dosage of BV and MEL for potential therapeutic use as well as potential side effects on normal cells and tissues to avoid any possible adverse event.

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Bee Venom Acupuncture for Neck Pain: A Review of the Korean Literature

Cited by 6 publications

References 55 publications

Anastasis induced by bee venom in normal cells compared to persistent cell death in breast cancer cells

Anastasis induced by bee venom in normal cells compared to persistent cell death in breast cancer cells

Selective Anastasis Induction by Bee Venom in Normal Cells: A Promising Strategy for Breast Cancer Therapy with Minimal Impact on Normal Cell Viability

Bee Venom: Composition and Anticancer Properties

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