Beetroot extract@chitosan nanocomposite as a promising approach towards cancer therapy

El-ghannam, Gamal; Moawad, Mahmoud; Abo-Elfadl, Mahmoud T.; Elfeky, Souad A.

doi:10.1016/j.ijbiomac.2024.129700

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.129700

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Beetroot extract@chitosan nanocomposite as a promising approach towards cancer therapy

Gamal El-ghannam,

Mahmoud Moawad,

Mahmoud T. Abo-Elfadl

et al.

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2024

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Cited by 4 publications

References 58 publications

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Smart Mesoporous Silica Nanoparticles Loading Curcumin Inhibit Liver Cancer

Man,

Liu,

et al. 2024

J. Agric. Food Chem.

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Curcumin (CUR) as one of the natural edible pigments is approved by the World Health Organization due to its nontoxic and anticancer effect. However, the utility of CUR is restricted due to its low oral bioavailability. Nanoparticle drug delivery systems like mesoporous silica nanoparticles (MSNs) have been extensively used due to their high specific surface area, high loading rate, and ease of modification. This study developed lactobionic acid (LA)-modified carboxymethyl chitosan (CMCS)-coated MSNs to deliver CUR specifically targeting hepatocellular carcinoma. Among these nanoparticles, LA targets liver cancer cells. CMCS utilizes pH-responsive release of CUR. The LA-CMCS-MSN@CUR (MSN@CUR) were evaluated using several methods, including Fourier transform infrared spectroscopy, transmission electron microscopy, and zeta potential measurements. Liver cellular uptake of MSN@CUR depends on a specific LA receptor-mediated endocytosis mechanism. Additionally, MSN@CUR performed with a better antitumor effect than Cur in H22 orthotopic transplantation of liver cancer and H22 solid tumor mouse models. Treatment with MSN@CUR significantly reduced the protein of VEGF, p-PI3K, and AKT, increased the protein of caspases 3 and 8, ultimately inhibited tumor migration, and promoted apoptosis. This study provides a new path for delivery of natural active ingredients with excellent bioavailability in the antitumor field.

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Smart Mesoporous Silica Nanoparticles Loading Curcumin Inhibit Liver Cancer

Man,

Liu,

et al. 2024

J. Agric. Food Chem.

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Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy

Dwivedi,

Sahoo,

Almalki

et al. 2024

Nanomedicine

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Betalains: A Narrative Review on Pharmacological Mechanisms Supporting the Nutraceutical Potential Towards Health Benefits

Martinez,

Melo,

Pinto

et al. 2024

Foods

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Betalains are naturally occurring pigments sourced mainly from Beta vulgaris (beetroot), Hylocereus spp. (dragon fruit), Amaranthus spp., and Opuntia spp. Betalains are widely used for their vibrant colors and health-promoting properties. These nitrogenous, water-soluble pigments are crucial colorants in the food industry, responsible for the red, purple, and yellow plant tissues, predominantly in the order Caryophyllales. They are grouped into betacyanins, with reddish-violet hues, and betaxanthins, yellow to orange. Examples include beetroot stems for betacyanins and yellow pitaya pulp for betaxanthins. Several pharmacological activities were reviewed in the scientific literature, describing their potential implications for human health. In this review, we focused on the main and latest studies on the pharmacological effects and mechanisms of betalains, including antioxidant, anti-inflammatory, antihypertensive, hypolipidemic, antidiabetic, hepatoprotective, neuroprotective, anticancer, and antimicrobial properties, in both in vitro and in vivo studies. Overall, betalain consumption is considered safe, with no major adverse effects or allergic reactions reported. We also approached topics such as the pharmacokinetics, bioavailability, stability, and enhanced stabilization of betalains. This article provides a comprehensive overview of bioactive potential of betalains, highlighting the biochemical mechanisms involved. The current knowledge broadens the clinical applicability of betalains, making them potential sources of nutraceutical compounds that can be used to develop functional foods.

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Beetroot extract@chitosan nanocomposite as a promising approach towards cancer therapy

Cited by 4 publications

References 58 publications

Smart Mesoporous Silica Nanoparticles Loading Curcumin Inhibit Liver Cancer

Smart Mesoporous Silica Nanoparticles Loading Curcumin Inhibit Liver Cancer

Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy

Betalains: A Narrative Review on Pharmacological Mechanisms Supporting the Nutraceutical Potential Towards Health Benefits

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