Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Yamamoto, Dorothy J.; Banich, Marie T.; Regner, Michael F.; Sakai, Joseph T.; Tanabe, Jody

doi:10.1016/j.drugalcdep.2017.08.024

“…The OFC comprises multiple subregions each implicated in distinct roles to support motivated behavior (Dixon et al, 2017 ). The left OFC increased activation to reward decision making in association with a behavioral approach personality trait (Yamamoto et al, 2017 ) and to loss trials when individuals know they are more likely to lose than not (Dong et al, 2013 ). Anatomically the lateral OFC is heavily connected with the somatomotor and premotor structures as well as the amygdala (Cavada et al, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

Motor Preparation Disrupts Proactive Control in the Stop Signal Task

Wang

¹

,

Hu

²

,

Ide

³

et al. 2018

Front. Hum. Neurosci.

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In a study of the stop signal task (SST) we employed Bayesian modeling to compute the estimated likelihood of stop signal or P(Stop) trial by trial and identified regional processes of conflict anticipation and response slowing. A higher P(Stop) is associated with prolonged go trial reaction time (goRT)—a form of sequential effect—and reflects proactive control of motor response. However, some individuals do not demonstrate a sequential effect despite similar go and stop success (SS) rates. We posited that motor preparation may disrupt proactive control more in certain individuals than others. Specifically, the time interval between trial and go signal onset—the fore-period (FP)—varies across trials and a longer FP is associated with a higher level of motor preparation and shorter goRT. Greater motor preparatory activities may disrupt proactive control. To test this hypothesis, we compared brain activations and Granger causal connectivities of 81 adults who demonstrated a sequential effect (SEQ) and 35 who did not (nSEQ). SEQ and nSEQ did not differ in regional activations to conflict anticipation, motor preparation, goRT slowing or goRT speeding. In contrast, SEQ and nSEQ demonstrated different patterns of Granger causal connectivities. P(Stop) and FP activations shared reciprocal influence in SEQ but FP activities Granger caused P(Stop) activities unidirectionally in nSEQ, and FP activities Granger caused goRT speeding activities in nSEQ but not SEQ. These findings support the hypothesis that motor preparation disrupts proactive control in nSEQ and provide direct neural evidence for interactive go and stop processes.

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“…Behavioral responsivity to appetitive stimuli has been associated with neural activity in the left orbitofrontal cortex, left insula, and right ventral striatum (Costumero et al, 2013). Substance Dependent Individuals (SDI) had higher BAS fun seeking scores, lower decision making performance, and elevated left OFC activity, indicating this region may play a role in rewardrelated decision making in SUD (Yamamoto et al, 2017). The BAS-drive trait also has been associated with modulating dorsomedial striatum activity (Costumero et al, 2016).…”

Section: Reward Hypersensitivity Modelmentioning

confidence: 99%

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

Sazhin¹,

Frazier²,

Haynes³

et al. 2020

Preprint

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This report describes an ongoing R03 grant that explores the links between trait reward sensitivity, substance use, and neural responses to social and nonsocial reward. Although previous research has shown that trait reward sensitivity and neural responses to reward are linked to substance use, whether this relationship is impacted by how people process social stimuli remains unclear. We are investigating these questions via a neuroimaging study with college-aged participants, using individual difference measures that examine the relation between substance use, social context, and trait reward sensitivity with tasks that measure reward anticipation, strategic behavior, social reward consumption, and the influence of social context on reward processing. We predict that substance use will be tied to distinct patterns of striatal dysfunction. Specifically, reward hyposensitive individuals will exhibit blunted striatal responses to social and non-social reward and enhanced connectivity with the orbitofrontal cortex; in contrast, reward hypersensitive individuals will exhibit enhanced striatal responses to social and non-social reward and blunted connectivity with the orbitofrontal cortex. We also will examine the relation between self-reported reward sensitivity, substance use, and striatal responses to social reward and social context. We predict that individuals reporting the highest levels of substance use will show exaggerated striatal responses to social reward and social context, independent of self-reported reward sensitivity. Examining corticostriatal responses to reward processing will help characterize the relation between reward sensitivity, social context and substance use while providing a foundation for understanding risk factors and isolating neurocognitive mechanisms that may be targeted to increase the efficacy of interventions.

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“…Behavioral responsivity to appetitive stimuli has been associated with neural activity in the left orbitofrontal cortex, left insula, and right ventral striatum [ 43 ] and the dorsomedial striatum [ 44 ]. Substance Dependent Individuals (SDI) had higher BAS fun seeking scores, lower decision making performance, and elevated left OFC activity, indicating this region may play a role in reward-related decision making in SUD [ 45 ]. Taken together, these studies indicate that dysregulated reward processing can then result in faulty decision making such as substance use.…”

Section: Significancementioning

confidence: 99%

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

Sazhin

¹

,

Frazier

²

,

Haynes

³

et al. 2020

J Psychiatry Brain Sci

View full text Add to dashboard Cite

This report describes an ongoing R03 grant that explores the links between trait reward sensitivity, substance use, and neural responses to social and nonsocial reward. Although previous research has shown that trait reward sensitivity and neural responses to reward are linked to substance use, whether this relationship is impacted by how people process social stimuli remains unclear. We are investigating these questions via a neuroimaging study with college-aged participants, using individual difference measures that examine the relation between substance use, social context, and trait reward sensitivity with tasks that measure reward anticipation, strategic behavior, social reward consumption, and the influence of social context on reward processing. We predict that substance use will be tied to distinct patterns of striatal dysfunction. Specifically, reward hyposensitive individuals will exhibit blunted striatal responses to social and non-social reward and enhanced connectivity with the orbitofrontal cortex; in contrast, reward hypersensitive individuals will exhibit enhanced striatal responses to social and non-social reward and blunted connectivity with the orbitofrontal cortex. We also will examine the relation between self-reported reward sensitivity, substance use, and striatal responses to social reward and social context. We predict that individuals reporting the highest levels of substance use will show exaggerated striatal responses to social reward and social context, independent of self-reported reward sensitivity. Examining corticostriatal responses to reward processing will help characterize the relation between reward sensitivity, social context and substance use while providing a foundation for understanding risk factors and isolating neurocognitive mechanisms that may be targeted to increase the efficacy of interventions.

show abstract

Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence

Cited by 10 publications

References 60 publications

Motor Preparation Disrupts Proactive Control in the Stop Signal Task

Motor Preparation Disrupts Proactive Control in the Stop Signal Task

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

The Role of Social Reward and Corticostriatal Connectivity in Substance Use

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