Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Gudapati, Kaavya; Singh, Anayesha; Clarkson-Townsend, Danielle; Phillips, Stephen Q.; Douglass, Amber; Feola, Andrew; Allen, Rachael S

doi:10.3791/61806-v

Cited by 5 publications

(1 citation statement)

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“…Sorbitol consumption was associated with a significant decrease in alternation response and motor coordination. Long‐term sorbitol consumption may promote cognitive decline, as alternating responses, which reflect cognitive function (Gudapati et al, 2020), were significantly reduced in the AS group. The effects of sorbitol may be more pronounced in terms of neurological function rather than in terms of metabolic health.…”

Section: Discussionmentioning

confidence: 99%

Long‐term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice

Yokoi,

Wang,

Ikuyo

et al. 2024

Genes to Cells

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The systemic effects of the artificial sweetener sorbitol on older adult individuals have not been elucidated. We assessed the effects of sorbitol consumption on cognitive and gingival health in a mouse model. Aged mice were fed 5% sorbitol for 3 months before their behavior was assessed, and brain and gingival tissues were collected. Long‐term sorbitol consumption inhibited gingival tissue aging in aged mice. However, it caused cognitive decline and decreased brain‐derived neurotrophic factor (BDNF) in the hippocampus. Sorbitol consumption did not affect homeostatic function; however, it may exert effects within the brain, particularly in the hippocampus.

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Section: Discussionmentioning

confidence: 99%