Behavioral, Biochemical and Histopathological effects of Standardised Pomegranate extract with Vinpocetine, Propolis or Cocoa in a rat model of Parkinson’s disease

Ali, Azza A.; Kamal, Mona M.; Khalil, Mona G.; Ali, Shimaa A.; Elariny, Hemat A.; Bekhit, Amany; Wahid, Ahmed

doi:10.1101/2020.06.03.131615

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Meanwhile, its leaf extracts have been exploited as an aboriginal remedy for various disorders, including cancer and infectious diseases. − Cocoa ( Theobroma cacao L.) belongs to the Sterculiaceae family and serves as an important economic crop in many African and Asian countries. , Cocoa powder has been used as a curative agent in the pathogenesis of several chronic diseases . For instance, approximately two spoons of cocoa powder in a cup of water or milk was used as a palliative treatment for Parkinson’s disease, mastitis, − liver diseases, sexual dysfunction, fever, cystitis, cold, burns, asthma, bronchitis, diabetes, and obesity. − In combination with other materials, a cocoa drink has been found to decrease the level of cholesterol in rats …”

Section: Introductionmentioning

confidence: 99%

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

Oluwajuyitan

Malomo

Badejo

et al. 2020

ACS Food Sci. Technol.

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The demand for low-cost and functional drinks is growing in most of the developing world, where starchy (mainly sugar) foods are the basic staples. In this study, the proximate composition, antioxidant, and phytochemical properties of the extracts from alkalized cocoa powder (ACP) and Carica papaya leaves were determined after blending and mixing them with aqueous and ethanol solvents. The level of crude fiber of the blends was 5-fold higher in 100% C. papaya leaves than in 75% ACP, but the ACP gave a 50% increase in protein content. Notably, C. papaya leaves in the ethanol extract gave higher free DPPH (77.54−85.5%), hydroxyl (83.86−94.16%), and radical scavenging and high metal chelating (32.35−55.82%) activities than the aqueous extract (72.07−83.26%, 71.28−89.83%, and 21.45−56.86%, respectively). On the contrary, ACP increased the phytochemical profiles (total flavonoid, tannin, and total phenols) of the extracts (1.76−2.56%, 12.47−20.58 mg/g, and 11.47−19.01 mg/g, respectively). Hence, the blends are laden with antioxidants that can provide health benefits to consumers.

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Section: Introductionmentioning

confidence: 99%

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

Oluwajuyitan

Malomo

Badejo

et al. 2020

ACS Food Sci. Technol.

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Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats

Nasehi

Mohammadi-Mahdiabadi-Hasani²,

Zarrindast

et al. 2021

J. Integr. Neurosci.

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Sleep deprivation has deteriorating effects on cognitive functions and activation of brain inflammation mechanisms has been reported by some studies following total sleep deprivation. Some studies have reported the health benefits of punicalagin, a main abstract from Punica granatum L., including those for the treatment of Alzheimer’s disease. The antioxidant characteristic of punicalagin and the fact that sleep deprivation accelerates mediators of inflammation led us to further explore the possible neuroprotective role of punicalagin in total sleep deprivation memory impairment in a rat model. In this study, male Wistar rats were implanted with a canula in the lateral ventricle to receive intracerebroventricular injections (drug or vehicle). The animals were trained for the passive avoidance test and then received intracerebroventricular injections of different doses of punicalagin (0.001, 0.01, or 0.1 μg/rat). Then, they were placed in the sleep deprivation apparatus for 24 hours and tested afterwards for memory retrieval and locomotion. Our results indicated that 24 hours of total sleep deprivation impaired memory processes. PG microinjection before TSD did not prevent the deteriorating effect of total sleep deprivation on memory, and only showed a tendency of restoring the memory impairment. Comparison of the locomotor activity between the animals in different groups showed a significant increase in the total sleep deprivation sham groups that received two of the highest doses of punicalagin. Considering the reported beneficial actions of PG by other studies, further investigation is needed into the possible effects of PG in memory alterations.

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Pomegranate (Punica granatum L.) Attenuates Neuroinflammation Involved in Neurodegenerative Diseases

Mehdi

Benchagra

Boulbaroud

et al. 2022

Foods

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Food scientists have studied the many health benefits of polyphenols against pernicious human diseases. Evidence from scientific studies has shown that earlier healthy lifestyle changes, particularly in nutrition patterns, can reduce the burden of age-related diseases. In this context, a large number of plant-derived components belonging to the class of polyphenols have been reported to possess neuroprotective benefits. In this review, we examined studies on the effect of dietary polyphenols, notably from Punica granatum L., on neurodegenerative disease, including Alzheimer’s disease, which is symptomatically characterized by impairment of cognitive functions. Clinical trials are in favor of the role of some polyphenols in maintaining neuronal homeostasis and attenuating clinical presentations of the disease. However, discrepancies in study design often bring inconsistent findings on the same component and display differences in their effectiveness due to interindividual variability, bioavailability in the body after administration, molecular structures, cross-blood-brain barrier, and signaling pathways such as nuclear factor kappa B (NF-κB). Based on preclinical and clinical trials, it appears that pomegranate may prove valuable in treating neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Therefore, due to the lack of information on human clinical trials, future in-depth studies, focusing on human beings, of several bioactive components of pomegranate’s polyphenols and their synergic effects should be carried out to evaluate their curative treatment.

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Behavioral, Biochemical and Histopathological effects of Standardised Pomegranate extract with Vinpocetine, Propolis or Cocoa in a rat model of Parkinson’s disease

Cited by 3 publications

References 22 publications

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats

Pomegranate (Punica granatum L.) Attenuates Neuroinflammation Involved in Neurodegenerative Diseases

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