Behavioral correlates of vitamin D deficiency

Altemus, Katharine L.; Finger, Stanley; Wolf, Cynthia; Birge, Stanley J.

doi:10.1016/0031-9384(87)90369-6

Cited by 37 publications

(33 citation statements)

References 20 publications

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“…A prospective study reported that women with low levels of vitamin D at baseline reported higher levels of depressive symptoms 3 and 6 years later [31]. 5 To date, there has only been one study to investigate the impact of AVD deficiency on brain function and behaviour in rodents [32]. However, in that study the SpragueDawley rats were fed a vitamin D deficient diet from weaning and they had reduced body weight compared to controls, which suggests that musculoskeletal problems may have confounded interpretation of behavioural outcomes in the study.…”

Section: Introductionmentioning

confidence: 99%

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Groves

Kesby

Eyles

et al. 2013

Behavioural Brain Research

126

111

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Epidemiological evidence suggests that low levels of vitamin D may predispose people to develop depression and cognitive impairment. While rodent studies have demonstrated that prenatal vitamin D deficiency is associated with altered brain development, there is a lack of research examining adult vitamin D (AVD) deficiency.The aim of this study was to examine the impact of AVD deficiency on behaviour and brain function in the mouse. Ten-week old male C57BL/6J and BALB/c mice were fed a control or vitamin D deficient diet for 10 weeks prior to, and during behavioural testing. We assessed a broad range of behavioural domains, excitatory and inhibitory neurotransmission in brain tissue, and, in separate groups of mice, locomotor response to D-amphetamine and MK-801. Overall, AVD deficiency resulted in hyperlocomotion in a novel open field and reduced GAD65/67 levels in brain tissue. AVD-deficient BALB/c mice had altered behaviour on the elevated plus maze, altered responses to heat, sound and shock, and decreased levels of glutamate and glutamine, and increased levels of GABA and glycine. By contrast C57BL/6 mice had a more subtle phenotype with no further behavioural changes but significant elevations in serine, homovanillic acid and 5-hydroxyindoleacetic acid.Although the behavioural phenotype of AVD did not seem to model a specific disorder, the overall reduction in GAD65/67 levels associated with AVD deficiency may be relevant to a number of neuropsychiatric conditions. This is the first study to show an association between AVD deficiency and prominent changes in behaviour and brain neurochemistry in the mouse.3

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Section: Introductionmentioning

confidence: 99%

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Groves

Kesby

Eyles

et al. 2013

Behavioural Brain Research

126

111

View full text Add to dashboard Cite

show abstract

“…One study from the late 1980s [27] examined male Sprague-Dawley rats made vitamin D deficient from weaning and examined at 3 months of age. The conclusion from this paper is that chronic post-weaning vitamin D deficiency (in the presence of normocalcaemia) altered the musculoskeletal system, but was not associated with alterations in learning (as assessed on two spatial memory tasks -radial arm maze and spatial reversal learning).…”

Section: Introductionmentioning

confidence: 99%

No Association between Serum 25-Hydroxyvitamin D<sub>3</sub> Level and Performance on Psychometric Tests in NHANES III

et al. 2007

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Background: Animal studies and in vitro experiments indicate that vitamin D is involved in a diverse range of neurobiological functions. We had the opportunity to examine the relationship between serum 25-hydroxyvitamin D₃ [25(OH)D] levels and performance on various cognitive tasks, based on a large, representative community sample. Methods: Three age groups were available from the population-based NHANES III survey: adolescent group (n = 1,676, age range 12–17 years), adult group (n = 4,747, 20–60 years), elderly group (n = 4,809, 60–90 years). The associations between eight psychometric measures and serum 25(OH)D were assessed. Results: In the adolescent and adult groups, none of the psychometric measures were associated with 25(OH)D levels. In the elderly group there was a significant difference between 25(OH)D quintiles performance on a learning and memory task; however, those with the highest quintile of 25(OH)D were most impaired on the task, contrary to the hypotheses. Conclusion: Lower 25(OH)D levels were not associated with impaired performance on various psychometric measures. While it remains to be seen if chronic exposure to low 25(OH)D levels alters brain function in the long term, this cross-sectional study suggests that 25(OH)D levels do not influence neurocognitive performance.

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“…VDRs are widespread in the brain and the spinal cord including the areas involved in the regulation of motor activity and behaviour [7][8][9][10]. Collectively, this implies a possible role of calcitriol and VDR in the regulation of behaviour [11][12][13]2,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Aberrant nest building and prolactin secretion in vitamin D receptor mutant mice

Keisala

Minasyan

Järvelin

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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Behavioral correlates of vitamin D deficiency

Cited by 37 publications

References 20 publications

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

No Association between Serum 25-Hydroxyvitamin D<sub>3</sub> Level and Performance on Psychometric Tests in NHANES III

Aberrant nest building and prolactin secretion in vitamin D receptor mutant mice

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