Behavioral effects evoked by the beta globin-derived nonapeptide LVV-H6

Cruz, Kellen Rosa da; Ianzer, Danielle; Turones, Larissa Córdova; Reis, Lilian Liz; Camargo-Silva, Gabriel; Mendonça, Michelle Mendanha; Silva, Elder Sales da; Pedrino, Gustavo Rodrigues; Castro, Carlos H.; Costa, Élson Alves; Xavier, Carlos Henrique

doi:10.1016/j.peptides.2019.03.002

Cited by 7 publications

(4 citation statements)

References 86 publications

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“…The least studied biological activities included anti-adipogenic (Grancieri et al, 2019), antiangiogenic (Silva et al, 2017a), anticoagulant , anticonvulsant (Silva et al, 2020), antidepressant (Cruz et al, 2017), antigenicity (Landim et al, 2021), antihistamine (Rádis- , antiproliferative (Santana et al, 2020), antisclerotic (Alves et al, 2016), anxiolytic (Cruz et al, 2019), cytoregulatory (Proksch et al, 2014), metal chelators (Montalvo et al, 2019), protease activator (Michelon et al, 2021), protection from DNA damage (Nascimento et al, 2021a), and protein inhibitor (Michelon et al, 2021) actions, each of which was tested and reported in only one publication.…”

Section: Researchers Affiliated With the Institutions In São Paulomentioning

confidence: 99%

Ten years of research on bioactive peptides in Brazil: a scientometric analysis

SILVA,

BARBOSA,

MARINHO

et al. 2023

Food Sci. Technol (Campinas)

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Peptides are biomolecules composed of amino acids linked through peptide bonds present in proteins. These peptides may have biological activities associated with their secondary structure, especially when released from the original protein sequence. The prospect of these biomolecules is the subject of study and research in various sectors, including the food and pharmaceutical industries. This is due to the possibility of using them as substitutes for traditionally marketed drugs, especially those with restrictive legislation on their use, or losing their effectiveness. A scientometric analysis of studies published from 2011 to 2021 by Brazilian researchers demonstrated the growing interest in basic research involving bioactive peptides from numerous protein sources, including food-based and agro-industrial residues. The antioxidant activity, followed by the antimicrobial potential, has been the most studied property of these biomolecules. Several other activities such as anxiolytic, anti-adipogenic, anticoagulant, anticonvulsant, antisclerotic, and cytoregulatory actions have been reported in a limited number of studies, highlighting the potential application of these biomolecules in the development of new products.

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Section: Researchers Affiliated With the Institutions In São Paulomentioning

confidence: 99%

Ten years of research on bioactive peptides in Brazil: a scientometric analysis

SILVA,

BARBOSA,

MARINHO

et al. 2023

Food Sci. Technol (Campinas)

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“…The hemoglobin instability can be explained as a consequence of an abnormal connection between the alpha and beta globins, especially in the α1β1 contacts, and also the blockage of the side chain (SH radical) of the amino acid cysteine (Cis) that occupies position 93 of the β polypeptide chain ( 76 , 78 ). Decreases in the globin attraction to its heme groups are consequences of amino acid replacements that participate in the molecule stabilization and of changes in those aminoacidic residues spatially surrounding the heme group ( 79 , 80 ). If these processes occur in the β globin, reactive changes of side chains would be expected.…”

Section: Clinical Exam and Proteomics: Perspectivesmentioning

confidence: 99%

“…Hemorphins have several activities, such as: antinociception acting as opioid receptor agonists ( 91 , 94 , 95 ); modulation on the activity of the calmodulin-dependent enzyme ( 96 ); inhibition of encephalin degradation ( 97 ) and angiotensin-converting-enzyme ( 78 ); induction release central β-endorphins ( 82 ), and; oxytocinergic activation ( 79 ). Hemoglobin-derived peptides also display antinociceptive ( 91 ) and cardiovascular effects ( 98 , 99 ), increases spatial learning ( 100 , 101 ) and cholinergic neurotransmission ( 102 ), modulates the pituitary-adrenal axis and reduces the activity of calcineurin ( 103 ).…”

Section: Clinical Exam and Proteomics: Perspectivesmentioning

confidence: 99%

Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19

Mendonça

Cruz

Pinheiro

et al. 2022

Hematology, Transfusion and Cell Therapy

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Introduction : The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective : Although management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results : Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion : The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.

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“…Through different mechanisms, LVV-H6 and LVV-H7 reduced anxiety-like responses in the elevated plus maze paradigm and depression-like behavior as assessed by immobility time during forced swim tests. 62 , 63 The effects of LVV-H7, in particular, were dependent on oxytocin receptors, since agonistic actions upon the AT4 receptor are postulated as a path to reducing oxytocin degradation exerted by this IRAP catalytic domain in physiological conditions. 15 , 39 , 64 Consequently, the antagonism of oxytocin receptors blocked the central effects of peripherally injected LVV-H7 in naive rats.…”

Section: Hemoglobin-derived Peptides As An Alternative Pathway Underl...mentioning

confidence: 99%

Are hemoglobin-derived peptides involved in the neuropsychiatric symptoms caused by SARS-CoV-2 infection?

Mendonça¹,

Cruz²,

Silva³

et al. 2022

Brazilian Journal of Psychiatry

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Follow-up of patients affected by COVID-19 has unveiled remarkable findings. Among the several sequelae caused by SARS-CoV-2 viral infection, it is particularly noteworthy that patients are prone to developing depression, anxiety, cognitive disorders, and dementia as part of the post-COVID-19 syndrome. The multisystem aspects of this disease suggest that multiple mechanisms may converge towards post-infection clinical manifestations. The literature provides mechanistic hypotheses related to changes in classical neurotransmission evoked by SARS-CoV-2 infection; nonetheless, the interaction of peripherally originated classical and non-canonic peptidergic systems may play a putative role in this neuropathology. A wealth of robust findings shows that hemoglobin-derived peptides are able to control cognition, memory, anxiety, and depression through different mechanisms. Early erythrocytic death is found during COVID-19, which would cause excess production of hemoglobin-derived peptides. Following from this premise, the present review sheds light on a possible involvement of hemoglobin-derived molecules in the COVID-19 pathophysiology by fostering neuroscientific evidence that supports the contribution of this non-canonic peptidergic pathway. This rationale may broaden knowledge beyond the currently available data, motivating further studies in the field and paving ways for novel laboratory tests and clinical approaches.

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Behavioral effects evoked by the beta globin-derived nonapeptide LVV-H6

Cited by 7 publications

References 86 publications

Ten years of research on bioactive peptides in Brazil: a scientometric analysis

Ten years of research on bioactive peptides in Brazil: a scientometric analysis

Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19

Are hemoglobin-derived peptides involved in the neuropsychiatric symptoms caused by SARS-CoV-2 infection?

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