1999
DOI: 10.1016/s0892-0362(98)00038-5
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Behavioral Effects Following Single and Combined Maternal Exposure to PCB 77 (3,4,3′,4′-Tetrachlorobiphenyl) and PCB 47 (2,4,2′,4′-Tetrachlorobiphenyl) in Rats

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Cited by 52 publications
(21 citation statements)
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“…These doses and routes of exposure are similar to those reported to generate PCB levels in rat adipose tissue and brains within the range of levels observed in humans (Bruun et al, 1990;Stellman et al, 1998;Hany et al, 1999;DeCaprio et al, 2005). These doses did not cause maternal or fetal toxicity as assessed by body weight of pregnant and lactating dams, litter size, and weight gain in pups.…”
Section: Polychlorinated Biphenyls (Pcbssupporting
confidence: 81%
“…These doses and routes of exposure are similar to those reported to generate PCB levels in rat adipose tissue and brains within the range of levels observed in humans (Bruun et al, 1990;Stellman et al, 1998;Hany et al, 1999;DeCaprio et al, 2005). These doses did not cause maternal or fetal toxicity as assessed by body weight of pregnant and lactating dams, litter size, and weight gain in pups.…”
Section: Polychlorinated Biphenyls (Pcbssupporting
confidence: 81%
“…Similar, but non-significant differences compared to controls, were observed after treatment with PCB 47 or a mixture of these congeners. The endpoint of this test was the time rats required to draw one or both paws from a vertical grid; in modified versions of the test (paws positioned on a bar or block), no differences were detected between PCB-treated rats and controls (Hany et al 1999a). In another publication by this group, significant effects were reported in another strain of rats, although this time differences were not observed in the ''vertical grid test'' but in the ''bar test'' only (WeinandHa¨rer et al 1997).…”
Section: Motor Activitymentioning
confidence: 99%
“…EthoVision is used by a number of groups for these measurements. For example, Hany et al (1999) looked at the behavioral effects on rat pups of exposing their mothers to PCBs during the gestation period. The behavior of the rats in an open field was measured using EthoVision.…”
Section: Toxicologymentioning
confidence: 99%