Behavioral effects of citrus limon in rats

Abstract

Anxiety and depression are increasing worldwide, however these disorders may be managed by making healthier changes is dietary pattern, since there are evidences that diet rich in antioxidants and vitamins help reduce anxiety and depression. Hence present study was designed to evaluate the behavioral effects of Citrus limon in rats at three different doses i.e. 0.2, 0.4 and 0.6 ml/kg considered as low, moderate and high doses. Anxiolytic and antidepressant activities were specifically assessed twice during 15 days using open field test, elevated plus maze and forced swimming test. In open field test C. limon, revealed increase in distance travelled, number of central entries and number of rearing's at moderate dose, while in the elevated plus maze, number of open arm entries were found to be increased. Whereas in forced swimming test, there was decrease in duration of immobility and increase in duration of climbing. Thus results of present study suggest that C. limon at moderate dose have anxiolytic effect.

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

“…Passive Avoidance is a fear-motivated test used to assess the short-or long-term memory of small animals, which measures the latency in entering a black compartment. Animals that were fed C. limon juice (0.2, 0.4 and 0.6 mL/kg) showed, in comparison with the control, a highly significant or a significant increase in latency before entering a black compartment after 3 and 24 h, respectively (Table 7) [64].…”

Medicinal plants with central nervous effects (part 2): plant based review

“…In open field test Citrus limon, revealed increase in distance travelled, number of central entries and number of rearing's at moderate dose, while in the elevated plus maze, number of open arm entries were found to be increased. Whereas in forced swimming test, there was decrease in duration of immobility and increase in duration of climbing [45].…”

Pharmacological Actions of Citrus Species

“…Whereas in the forced swimming test, there was a decrease in duration of immobility and an increase in the duration of climbing. Thus, results suggest that C. limon at moderate dose has an anxiolytic effect [53].…”