Behavioral health disorders related to nonalcoholic steatohepatitis

Sharma, Aadi; Albhaisi, Somaya; Sanyal, Arun J.

doi:10.1002/cld.1211

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…It is becoming increasingly evident that peripheral organ-centered inflammatory diseases, including liver diseases such as MASLD/MASH, are linked with brain dysfunctions, including impairments in neurotransmission, leading to behavioral alterations [ 10 , 41 , 42 ], or in severe cases, the development of neuropsychiatric syndrome of HE [ 43 ]. Presently, WD-fed mice were inattentive and had pronounced motor impairments, enhanced anxiety and HTR behaviors.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet

Custodio,

Hobloss,

Myllys

et al. 2023

Cells

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Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is the most common chronic liver disease in Western countries. It is becoming increasingly evident that peripheral organ-centered inflammatory diseases, including liver diseases, are linked with brain dysfunctions. Therefore, this study aims to unravel the effect of MASLD on brain histology, cognitive functions, and neurotransmitters. For this purpose, mice fed for 48 weeks on standard (SD) or Western diet (WD) were evaluated by behavioral tests, followed by sacrifice and analysis of the liver-brain axis including histopathology, immunohistochemistry, and biochemical analyses. Histological analysis of the liver showed features of Metabolic Dysfunction-Associated Steatohepatitis (MASH) in the WD-fed mice including lipid droplet accumulation, inflammation, and fibrosis. This was accompanied by an elevation of transaminase and alkaline phosphatase activities, increase in inflammatory cytokine and bile acid concentrations, as well as altered amino acid concentrations in the blood. Interestingly, compromised blood capillary morphology coupled with astrogliosis and microgliosis were observed in brain hippocampus of the WD mice, indicating neuroinflammation or a disrupted neurovascular unit. Moreover, attention was impaired in WD-fed mice along with the observations of impaired motor activity and balance, enhanced anxiety, and stereotyped head-twitch response (HTR) behaviors. Analysis of neurotransmitters and modulators including dopamine, serotonin, GABA, glutamate, and acetylcholine showed region-specific dysregulation in the brain of the WD-fed mice. In conclusion, the induction of MASH in mice is accompanied by the alteration of cellular morphology and neurotransmitter expression in the brain, associated with compromised cognitive functions.

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Section: Discussionmentioning

confidence: 99%

Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet

Custodio,

Hobloss,

Myllys

et al. 2023

Cells

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“…One of the main causes of obesity and NAFLD is eating disorders (ED), which cause about 7000 deaths per year (as of 2020), making them the mental diseases with the highest mortality [9][10][11] . In developed countries, about 1.6% of women and 0.8% of men suffer from psychogenic overeating, depending on the year.…”

Section: Introductionmentioning

confidence: 99%

Complex correction of eating behaviour disorders, anthropometric and physiological indicators in patients with non-alcoholic fatty liver disease on the background of abdominal obesity

Kiro

Zak

Kushnіrenko

et al. 2023

HSR

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Purpose: to evaluate the effectiveness of correction of eating behaviour disorders, anthropometric, physiological indicators by impFreelementing combined non-drug treatment for patients with non-alcoholic fatty liver disease on the background of abdominal obesity. Material and methods 85 patients with non-alcoholic fatty liver disease on the background of abdominal obesity of the 1st degree were examined. All patients were divided into two clinical groups: 1st group (research) - 48 people, with average body mass index BMI=32.55±1.07 kg/m2, who underwent a course of cognitive behavioural therapy, diet therapy, and physical activity for 6 months; the control group - 37 people with average BMI=31.95±1.03 kg/m2 followed only a rational diet and physical activity, without cognitive behavioural therapy. The examination of the patients included the measurement of anthropometric and physiological indicators, questionnaires according to the DEBQ (Dutch Eating Behaviour Questionnaire). Results On the 180th day, the number of patients with normal blood pressure in the 1st group increased in 2.38 times (D=2.3511, p=0.0015), healthy eating behavior was recorded in 2.38 times more often (D=0.2215, p=0.0047) and the number of restrictive type of EB decreased in 2.0 times (D=0.4321, p=0.0031), compared to the control group. Conclusion A combined course of therapy in the form of a rational diet, aerobic exercise and cognitive behavioural therapy should be an integral component of early non-drug treatment, as a guarantee not only of the correction of anthropometric and functional indicators, but also of the modification of the eating behavior and a guarantee of long-term maintenance of the desired weight.

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“…In addition to the companion article in this issue of Clinical Liver Disease, "Behavioral Health Disorders Related to Nonalcoholic Steatohepatitis," we highlight in this review the nonpharmacological and pharmacological strategies for weight loss in the context of NASH and mental health disorders. 2…”

Section: Introductionmentioning

confidence: 99%

“…Because obesity is linked with mental health disorders and is a major risk factor for NASH, weight loss treatment requires multifaceted approaches. In addition to the companion article in this issue of Clinical Liver Disease , “Behavioral Health Disorders Related to Nonalcoholic Steatohepatitis,” we highlight in this review the nonpharmacological and pharmacological strategies for weight loss in the context of NASH and mental health disorders 2 …”

Section: Introductionmentioning

confidence: 99%

Treatments for obesity in the context of nonalcoholic steatohepatitis and mental health

Sharma

Albhaisi

Sanyal

2022

Clinical Liver Disease

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Behavioral health disorders related to nonalcoholic steatohepatitis

Abstract: Content available: Author Interview and Audio Recording

Cited by 4 publications

References 33 publications

Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet

Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet

Complex correction of eating behaviour disorders, anthropometric and physiological indicators in patients with non-alcoholic fatty liver disease on the background of abdominal obesity

Treatments for obesity in the context of nonalcoholic steatohepatitis and mental health

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