Behavioral, hormonal and central serotonin modulating effects of injected leptin

Haleem, Darakhshan Jabeen; Haque, Zeba; Inam, Qurrat-ul-Aen; Ikram, Huma; Haleem, Muhammad Abdul

doi:10.1016/j.peptides.2015.10.002

Cited by 25 publications

(20 citation statements)

References 52 publications

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“…First, leptin may be involved in regulation of serotonin (5-HT) and dopamine (DA), which are the key neurotransmitters in the classic aetiological hypothesis of depression. Previous studies have found that intraperitoneal administration of leptin dose dependently significantly increased serum 5-HT levels,35 while leptin-deficient ob/ob mice exhibited impaired DA functions and decreased DA release 36. Second, leptin may have direct and indirect neurotrophic effects, which are disrupted in depression.…”

Section: Discussionmentioning

confidence: 98%

Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia

Jiao

Xing

et al. 2018

Gen Psych

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BackgroundDepressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia.ObjectiveAimsTo assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.MethodsCross-sectional studies were applied to (1) compare the levels of plasma leptin between schizophrenia (n=74) and healthy controls (n=50); and (2) investigate the relationship between plasma leptin levels and depressive subscores.Results(1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls. (2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale (PANSS). (3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.ConclusionLeptin may serve as a predictor for the depressive symptoms of chronic schizophrenia.

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Section: Discussionmentioning

confidence: 98%

Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia

Jiao

Xing

et al. 2018

Gen Psych

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“…153,154 Serotonin and stress are tightly linked, and the administration of serotonin agonists increases CORT levels in rats. 336 The complex relationship between estrogen and serotonin is reviewed elsewhere and is outside the scope of this review.…”

Section: Non-homeostatic Control Of Feeding and Activitymentioning

confidence: 99%

Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa

Ross

Mandelblat-Cerf

Verstegen

2016

Harv Rev Psychiatry

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Anorexia nervosa (AN) is a psychiatric illness with minimal effective treatments and a very high rate of mortality. Understanding the neurobiological underpinnings of the disease is imperative for improving outcomes and can be aided by the study of animal models. The activity-based anorexia rodent model (ABA) is the current best parallel for the study of AN. This review describes the basic neurobiology of feeding and hyperactivity seen in both ABA and AN, and compiles the research on the role that stress-response and reward pathways play in modulating the homeostatic drive to eat and to expend energy, which become dysfunctional in ABA and AN.

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“…The extended feeding durations were selected based on data indicating that leptin signaling dysregulation, characterized by hyperleptinemia or leptin resistance, develops in male and female mice after 15–20 weeks on HFD [19–23] and that leptin status affects anxiety behavior and serotonin signaling [24]. In addition learning deficits caused by HFD appear to be age-dependent [25].…”

Section: Introductionmentioning

confidence: 99%

Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake

Krishna

Lin

Serre

et al. 2016

Physiology & Behavior

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High-fat diet (HFD) induced obesity is associated not only with metabolic dysregulation, e.g., impaired glucose homeostasis and insulin sensitivity, but also with neurological dysfunction manifested with aberrant behavior and/or neurotransmitter imbalance. Most studies have examined HFD's effects predominantly in male subjects, either in the periphery or on the brain, in isolation and after a finite feeding period. In this study, we evaluated the time-course of selected metabolic, behavioral, and neurochemical effects of HFD intake in parallel and at multiple time points in female (C57BL/6) mice. Peripheral effects were evaluated at three feeding intervals (short: 5–6 weeks, long: 20–22 weeks, and prolonged: 33–36 weeks). Central effects were evaluated only after long and prolonged feeding durations; we have previously reported those effects after the short (5–6 weeks) feeding duration) [1]. Ongoing HFD feeding resulted in an obese phenotype characterized by increased visceral adiposity and, after prolonged HFD intake, an increase in liver and kidney weights. Peripherally, 5 weeks of HFD intake was sufficient to impair glucose tolerance significantly, with the deleterious effects of HFD being greater with prolonged intake. Similarly, 5 weeks of HFD consumption was sufficient to impair insulin sensitivity. However, sensitivity to insulin after prolonged HFD intake was not different between control, low-fat diet (LFD) and HFD-fed mice, most likely due to age-dependent decrease in insulin sensitivity in the LFD-fed mice. HFD intake also induced bi-phasic hepatic inflammation and it increased gut permeability. Behaviorally, prolonged intake of HFD caused mice to be hypoactive and bury fewer marbles in a marble burying task; the latter was associated with significantly impaired hippocampal serotonin homeostasis. Cognitive (short-term recognition memory) function of mice was unaffected by chronic HFD feeding. Considering our prior findings of short-term (5–6 weeks) HFD-induced central (hyperactivity/anxiety and altered ventral hippocampal neurochemistry) effects and our current results, it seems that in female mice some metabolic/inflammatory dysregulations caused by HFD, such as gut permeability, appear early and persist, whereas others, such as glucose intolerance, are exaggerated with continuous HFD feeding; behaviorally, prolonged HFD consumption mainly affects locomotor activity and anxiety-like responses, likely due to the advanced obesity phenotype; neurochemically, the serotonergic system appears to be most sensitive to continued HFD feeding.

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Behavioral, hormonal and central serotonin modulating effects of injected leptin

Cited by 25 publications

References 52 publications

Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia

Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia

Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa

Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake

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