Behavioral reactions of rats and the contents of neurospecific proteins in their brain after single X-ray irradiation

Radiation-Induced Cognitive Dysfunction After Different Schemes of Fractionated Whole Brain Irradiation

“…In the hippocampus the lowest level of VEGF was in 36Gy/6 group, which received the maximum BED. In available literature both increase and decrease of the VEGF expression are reported (Leshchinskaya et al, 2000;Ma et al, 2001;Balentova et al, 2012), however, the dose of radiation, the method of fractionation and the timing of material sampling are different, so, comparing the data is difficult. It is possible that increase or decrease of the VEGF expression depends on the time elapsed after radiation and on the received dose.…”

“…Decreased or increased density of glial cells has been shown in many fundamental works on animal models that were aimed on research of irradiation consequences. Moreover, the expression of Glial Fibrillar Acid Protein (GFAP) changes irregularly in various brain structures; increased expression in one group and decreased in another (Nagayama et al, 2001;Yuan et al, 2006;Leshchinskaya et al, 2000;Ma et al, 2001;Balentova et al, 2012). This indicates that various brain structures have different reactions to radiation injury.…”

Blood—brain barrier permeability in healthy rats and rats with experimental C6 glioma after fractionated radiotherapy of the brain

“…С увеличе-нием разовой дозы одной фракции возрастает сте-пень выраженности когнитивных расстройств [22,29,30], поэтому в исследованиях по проницаемости ГЭБ у предварительно здоровых крыс (без глиомы) были выбраны режимы фракционирования, пока-завшие свою эффективность в быстрой стабилиза-ции объема глиомы С6, но без остро выраженных побочных эффектов, а именно: 4 Гр×6 фракций и длительное облучение небольшими дозами 2 Гр×9 фракций [31].…”