2011
DOI: 10.1016/j.ejphar.2011.04.035
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Behavioral sensitization and cross-sensitization between methylphenidate amphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in female SD rats

Abstract: The psychostimulants amphetamine and methylphenidate (MPD / Ritalin) are the drugs most often used to treat attention deficit hyperactivity disorder (ADHD). In addition, students of all ages take these drugs to improve academic performance but also abuse them for pleasurable enhancement. In addition, other psychostimulants such 3,4 methylenedioxymethamphetamine (MDMA / ecstasy) are used / abused for similar objectives. One of the experimental markers for the potential of a drug to produce dependence is its abi… Show more

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Cited by 38 publications
(27 citation statements)
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“…The open field system 16 and 8 infrared beams and their sensors on the opposite side set at 5 cm above the floor of the cage. The open field assay has been previously described in detail (Gaytan et al, 1996, 1997a, b, 2000; Yang et al, 2006a, 2007, 2011). In short, the activity monitoring system checked each of the sensor beams at a 100 Hz frequency to determine whether beams were interrupted.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…The open field system 16 and 8 infrared beams and their sensors on the opposite side set at 5 cm above the floor of the cage. The open field assay has been previously described in detail (Gaytan et al, 1996, 1997a, b, 2000; Yang et al, 2006a, 2007, 2011). In short, the activity monitoring system checked each of the sensor beams at a 100 Hz frequency to determine whether beams were interrupted.…”
Section: Methodsmentioning
confidence: 99%
“…Tolerance to a drug refers to drug induced adaptations that lead to attenuating effects when the same dose of that drug is given again; to get the same effect, a higher dose is required. Alternatively, behavioral sensitization is a progressive amplification of behavioral responses to repeated psychostimulant exposure (Chao and Nestler, 2004; Dafny and Yang 2006; Gaytan et al, 1996; Kalivas et al, 1988; Lee et al, 2009; Robinson 1984; Wolf 1988; Yang et al, 2003, 2011). Behavioral tolerance and sensitization are experimental markers used to indicate the potential of a psychostimulant to elicit drug dependence.…”
Section: Introductionmentioning
confidence: 99%
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“…In experimental settings, psychostimulant sensitization is commonly demonstrated as increased locomotor activity following repeated exposures to the drug. Several reports indicate that repeated exposure to MPH induces locomotor sensitization in rodents (Askenasy et al , 2007; Yang et al , 2011; Yang et al , 2007). …”
Section: Introductionmentioning
confidence: 99%