Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia

Meng, Xin; Abazyan, Sofya; Jouroukhin, Yan; Pletnikov, Mikhail V.

doi:10.1016/j.schres.2014.10.044

Cited by 37 publications

(34 citation statements)

References 190 publications

(207 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S100β knockout mice displayed enhanced synaptic plasticity and performed better in contextual fear conditioning paradigms. These data were linked the structural changes seen in schizophrenia (Xia et al, 2016). …”

Section: Is There a Causal Role For Glia In Neurodevelopmental Disordmentioning

confidence: 97%

See 1 more Smart Citation

The Indispensable Roles of Microglia and Astrocytes during Brain Development

Reemst

Noctor

Lucassen

et al. 2016

Front. Hum. Neurosci.

437

387

View full text Add to dashboard Cite

Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development. Although both cells are fundamentally different in origin and function, they often affect the same developmental processes such as neuro-/gliogenesis, angiogenesis, axonal outgrowth, synaptogenesis and synaptic pruning. Due to their important instructive roles in these processes, dysfunction of microglia or astrocytes during brain development could contribute to neurodevelopmental disorders and potentially even late-onset neuropathology. A better understanding of the origin, differentiation process and developmental functions of microglia and astrocytes will help to fully appreciate their role both in the developing as well as in the adult brain, in health and disease.

show abstract

Section: Is There a Causal Role For Glia In Neurodevelopmental Disordmentioning

confidence: 97%

“…Various studies have implicated a role for astrocytes in the pathophysiology of schizophrenia, as reviewed in detail by Xia et al (2016) and Mitterauer (2005). Two studies further imply a causal role for the dysfunction of astrocytes in the development of schizophrenia.…”

Section: Is There a Causal Role For Glia In Neurodevelopmental Disordmentioning

confidence: 99%

The Indispensable Roles of Microglia and Astrocytes during Brain Development

Reemst

Noctor

Lucassen

et al. 2016

Front. Hum. Neurosci.

437

387

View full text Add to dashboard Cite

show abstract

“…Astrocytes are central for both synaptogenesis and the maintenance of glutamatergic transmission and hence their contribution to schizophrenia has been receiving an increased attention (Bernstein et al, 2015; Kondziella et al, 2007; Sanacora and Banasr, 2013; Verkhratsky et al, 2014d; Xia et al, 2014). The number of main types of neuroglia, the oligodendrocytes and astrocytes, is generally decreased in the schizophrenic brain, with some regional variations (Xia et al, 2014). There are no signs of reactive astrogliosis in schizophrenia (Rajkowska et al, 2002; Rajkowska et al, 1998; Schnieder and Dwork, 2011; Williams et al, 2013).…”

Section: Astroglia In Neuropsychiatric Diseasesmentioning

confidence: 99%

Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders

Verkhratsky

Parpura

2016

Neurobiology of Disease

135

View full text Add to dashboard Cite

Astroglial cells represent a main element in the maintenance of homeostasis and providing defense to the brain. Consequently, their dysfunction underlies many, if not all, neurological, neuropsychiatric and neurodegenerative disorders. General astrogliopathy is evident in diametrically opposing morpho-functional changes in astrocytes, i.e. their hypertrophy along with reactivity or atrophy with asthenia. Neurological disorders with astroglial participation can be genetic, of which Alexander disease is a primary sporadic astrogliopathy, environmentally caused, such as heavy metal encephalopathies, or neurodevelopmental in origin. Astroglia also play a role in major neuropsychiatric disorders, ranging from schizophrenia to depression, as well as in additive disorders. Furthermore, astroglia contribute to neurodegenerative processes seen in amyotrophic lateral sclerosis, Alzheimer’s and Huntington’s diseases.

show abstract

“…Astroglial reactivity in schizophrenia remains a debatable matter, as it might be tainted by age, medication and other associated factors (Schnieder and Dwork, 2011). In addition, a significant decrease in expression of astroglia-specific molecules fundamental for CNS homeostasis, including deiodinase type II, aquaporin-4, S100β, glutamine synthetase, plasmalemmal glutamate transporters, and thrombospondin, was found in the deep layers of the anterior cingulate gyrus, suggesting that a subset of astrocytes localized to specific cortical layers can be affected in schizophrenia (Xia et al ., 2014). Decreased expression of EAAT1/2 plasmalemmal glutamate transporters is documented for the prefrontal cortex (Bauer et al ., 2008; Bauer et al ., 2010) and hippocampus (Ohnuma et al ., 2000; Shan et al ., 2013).…”

Section: Astroglia In Major Neuropsychiatric Diseasesmentioning

confidence: 99%

Translational potential of astrocytes in brain disorders

Verkhratsky

Steardo²,

Parpura

et al. 2016

Progress in Neurobiology

View full text Add to dashboard Cite

Fundamentally, all brain disorders can be broadly defined as the homeostatic failure of this organ. As the brain is composed of many different cells types, including but not limited to neurons and glia, it is only logical that all the cell types/constituents could play a role in health and disease. Yet, for a long time the sole conceptualization of brain pathology was focused on the well-being of neurons. Here, we challenge this neuron-centric view and present neuroglia as a key element in neuropathology, a process that has a toll on astrocytes, which undergo complex morpho-functional changes that can in turn affect the course of the disorder. Such changes can be grossly identified as reactivity, atrophy with loss of function and pathological remodeling. We outline the pathogenic potential of astrocytes in variety of disorders, ranging from neurotrauma, infection, toxic damage, stroke, epilepsy, neurodevelopmental, neurodegenerative and psychiatric disorders, Alexander disease to neoplastic changes seen in gliomas. We hope that in near future we would witness glial-based translational medicine with generation of deliverables for the containment and cure of disorders. We point out that such as a task will require a holistic and multi-disciplinary approach that will take in consideration the concerted operation of all the cell types in the brain.

show abstract

Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia

Cited by 37 publications

References 190 publications

The Indispensable Roles of Microglia and Astrocytes during Brain Development

The Indispensable Roles of Microglia and Astrocytes during Brain Development

Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders

Translational potential of astrocytes in brain disorders

Contact Info

Product

Resources

About