Behaviour of HPMC compacts investigated using UV-imaging

Pajander, Jari; Baldursdóttir, Stefanía; Rantanen, Jukka; Østergaard, Jesper

doi:10.1016/j.ijpharm.2012.02.034

Cited by 47 publications

(28 citation statements)

References 43 publications

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“…However, with passage of time, the core of matrix also gets hydrated. The drug release from this swollen matrix is due to disentanglement of surface polymeric chains resulting in erosion and due to diffusion of media into the discs through the swollen matrix (Tajarobi et al, 2009;Chen et al, 2010;Pajander et al, 2012;Asare-Addo et al, 2013). Due to solubilization of components of matrix, the number of pores and pore diameter in swollen matrix increases thereby resulting in further drug release.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Jaipal

Pandey

et al. 2014

Drug Delivery

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Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Jaipal

Pandey

et al. 2014

Drug Delivery

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“…Synchrotron‐based X‐ray diffraction experiments have recently been suggested to be a promising approach for investigating fast transformation kinetics . Recent advances in dissolution testing have also been achieved by the introduction of imaging techniques, including magnetic resonance imaging, Fourier transformed infrared (FTIR) and UV imaging providing real‐time data. UV imaging facilitates spatially (2D) and temporally resolved quantification of drug substance in solution immediately adjacent to the solid material .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous UV Imaging and Raman Spectroscopy for the Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing

Østergaard¹,

Wu²,

Naelapää³

et al. 2014

Journal of Pharmaceutical Sciences

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“…UV imaging has further been applied to studying drug release from cocrystals, hydroxypropyl methyl cellulose (HPMC) compacts, film‐coated extrudates and nanocrystal powders [78–82]. Furosemide dissolution was investigated in a biorelevant medium by means of UV imaging [83].…”

Section: Real‐time Analysis Of Small‐scale Drug Dissolution and Precimentioning

confidence: 99%

“…UV imaging has further been applied to studying drug release from cocrystals, hydroxypropyl methyl cellulose (HPMC) compacts, film-coated extrudates and nanocrystal powders. [78][79][80][81][82] Furosemide dissolution was investigated in a biorelevant medium by means of UV imaging. [83] Rather high variability was observed between individual experiments, which was explained by effects of swelling and recrystallisation on the compact surface.…”

Section: Focusing Lensmentioning

confidence: 99%

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

Kuentz

2015

Journal of Pharmacy and Pharmacology

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Objectives This review focuses on real-time analytics of drug dissolution and precipitation testing on a comparatively small scale. Key findings Miniaturisation of test equipment is an important trend in pharmaceutics, and several small-scale experiments have been reported for drug dissolution and precipitation testing. Such tests typically employ analytics in realtime. Fibre optic ultraviolet (UV) analytics has become a well-established method in this field. Novel imaging techniques are emerging that use visible or UV light; also promising is Fourier transform infrared imaging based on attenuated total reflection. More information than just a rate constant is obtained from these methods. The early phase of a dissolution process can be assessed and drug precipitation may eventually be observed. Some real-time techniques are particularly well suited to studying drug precipitation during formulation dispersion; for example, turbidity, focused beam reflectance measurement and Raman spectroscopy. Summary Small-scale dissolution tests equipped with real-time analytics have become important to screen drug candidates as well as to study prototype formulations in early development. Future approaches are likely to combine different analytical techniques including imaging. Miniaturisation started with mini-vessels or small vials and future assays of dissolution research will probably more often reach the level of parallel well plates and microfluidic channels.

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Behaviour of HPMC compacts investigated using UV-imaging

Cited by 47 publications

References 43 publications

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

Simultaneous UV Imaging and Raman Spectroscopy for the Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

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