Behaviour of silver nanoparticles in simulated saliva and gastrointestinal fluids

Pinďáková, Lucie; Kašpárková, Věra; Kejlová, Kristína; Dvořáková, Marcela; Krsek, Daniel; Jírová, Dagmar; Kašparová, Lucie

doi:10.1016/j.ijpharm.2017.05.026

Cited by 69 publications

(39 citation statements)

References 31 publications

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“…In addition, it was seen that NPs smaller than 10 nm were added to a greater extent than larger one [96]. It was also demonstrated that depending on the composition and pH, the morphology and the size of the Ag-NPs changed when passing through the different fluids (simulated saliva and gastric and intestinal fluids); in addition, there was only a low toxicity in a pilot study of reconstituted human tissues model [85]. When Ag-NPs interact with proteins, a corona is always formed and it decreases the entry of nanoparticles into cells and therefore, cellular toxicity decreases [97].…”

Section: In Vitro Studies: Static and Dynamic Gut Simulators And Epitmentioning

confidence: 96%

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

et al. 2020

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Foodborne diseases are one of the factors that endanger the health of consumers, especially in people at risk of exclusion and in developing countries. The continuing search for effective antimicrobials to be used in the food industry has resulted in the emergence of nanotechnology in this area. Silver nanoparticles (Ag-NPs) are the nanomaterial with the best antimicrobial activity and therefore, with great potential of application in food processing and packing. However, possible health effects must be properly addressed to ensure food safety. This review presents a detailed description on the main applications of Ag-NPs as antimicrobial agents for food control, as well as the current legislation concerning these materials. Current knowledge about the impact of the dietary exposure to Ag-NPs in human health with special emphasis on the changes that nanoparticles undergo after passing through the gastrointestinal tract and how they alter the oral and gut microbiota, is also summarized. It is concluded that given their potential and wide properties against foodborne pathogens, research in Ag-NPs is of great interest but is not exempt from difficulties that must be resolved in order to certify the safety of their use.

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Section: In Vitro Studies: Static and Dynamic Gut Simulators And Epitmentioning

confidence: 96%

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

et al. 2020

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“…Nanotechnologists in the field of food sciences have started to acknowledge the importance of PC on the fate and toxicity of ingested food-grade NPs [8]. It has been shown that incubation of silver NPs in simulated gastric media containing pepsin can result in the formation of PC, which facilitates NP aggregation [9,10]. Similarly, PC can also build upon the surface of polystyrene NPs exposed to various digestive enzymes [11].…”

Section: What Is It Known So Far?mentioning

confidence: 99%

Oral delivery of nanoparticles - let’s not forget about the protein corona

Berardi

Bombelli²

2019

Expert Opinion on Drug Delivery

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“…[35,37,39,40] Besides, once ingested, AgNPs pass through the GIT in which physiological parameters (e.g., pH, ionic strength, protein composition) are constantly evolving and thus influencing the features of AgNPs throughout the digestion process. [38,41,42] As toxic effects of NMs are related to their physicochemical properties, [21,43] all the alterations that could take place before AgNPs attain the intestinal cells might affect their potential toxicity [35,39] and must therefore be included in cytotoxicity investigations to realize an accurate risk assessment. [37] The European Food Safety Authority (EFSA) has published a guidance in which recommendations were given for risk assessment of nanomaterials used in the food chain.…”

Section: Introductionmentioning

confidence: 99%

“…[38,41,42,[47][48][49][50][51] However, most of them did not take into account the presence of food components that can also impact their behavior. [41,42,47,50,51] Two studies have nevertheless characterized the fate of poly(acrylic acid) stabilized ultrasmall AgNPs with a radius around 3 nm in the presence of the major food components, mimicked by the presence of starch, olive oil, and skimmed milk powder during the digestion process but particle size distribution was only analyzed with small-angle X-ray scattering. [38,48] Another study investigated the behavior of AgNPs incorporated in chicken meat during the digestion process but only single-particle inductive coupled plasma-mass spectrometry was applied.…”

Section: Introductionmentioning

confidence: 99%

The Food Matrix and the Gastrointestinal Fluids Alter the Features of Silver Nanoparticles

Laloux

Kastrati

Cambier

et al. 2020

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Silver nanoparticles (AgNPs) are used in the agri‐food sector, which can lead to their ingestion. Their interaction with food and their passage through the gastrointestinal tract can alter their properties and influence their fate upon ingestion. Therefore, this study aims at developing an in vitro method to follow the fate of AgNPs in the gastrointestinal tract. After incorporation of AgNPs into a standardized food matrix, a precolonic digestion is simulated and AgNPs are characterized by different techniques. The presence of food influences the AgNPs properties by forming a corona around nanoparticles. Even if the salivary step does not impact significantly the AgNPs, the pH decrease and the digestive enzymes induce the agglomeration of AgNPs during the gastric phase, while the addition of intestinal fluids disintegrates these clusters. AgNPs can thus reach the intestinal cells under nanometric form, although the presence of food and gastrointestinal fluids modifies their properties compared to pristine AgNPs. They can form a corona around the nanoparticles and act as colloidal stabilizer, which can impact the interaction of AgNPs with intestinal epithelium. This study demonstrates the importance of taking the fate of AgNPs in the gastrointestinal tract into account to perform an accurate risk assessment of nanomaterials.

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Behaviour of silver nanoparticles in simulated saliva and gastrointestinal fluids

Cited by 69 publications

References 31 publications

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

Oral delivery of nanoparticles - let’s not forget about the protein corona

The Food Matrix and the Gastrointestinal Fluids Alter the Features of Silver Nanoparticles

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