Behavioural and electroencephalographic effects of systemic injections of 8-OH-DPAT in the pigeon (Columba livia)

Santos, Murilo Marcos dos; Hoeller, Alexandre Ademar; Santos, Tiago Souza dos; Felisbino, Manuela Brisot; Herdt, Marcello Alberton; Silva, Eduardo Simão da; Paschoalini, Marta Aparecida; Marino–Neto, José

doi:10.1016/j.bbr.2009.02.017

Cited by 10 publications

(3 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5; Buzsáki, 1986, 1989; Sirota & Buzsáki, 2005; Ulanovsky & Moss, 2007). In contrast to mammals, such hippocampal sharp‐wave/ripples (SWRs) have not been reported in birds during SWS (Ookawa & Gotoh, 1965; Van Twyver & Allison, 1972; Sugihara & Gotoh, 1973; Szymczak, 1987; Fuchs et al , 2006; Martinez‐Gonzalez et al , 2008, Dos Santos et al , 2009). Instead, the avian hippocampus tends to show only slow‐waves similar to those observed in other pallial regions, albeit with a lower amplitude during SWS (Sugihara & Gotoh, 1973).…”

Section: Avian and Mammalian Sleepmentioning

confidence: 99%

“…Although birds exhibit EEG activation and other features characteristic of mammalian REM sleep (e.g. rapid eye movements, twitching, reduced muscle tone, and reduced thermoregulation), a hippocampal theta rhythm has not been observed during avian REM sleep (Berger & Walker, 1972; Van Twyver & Allison, 1972; Sugihara & Gotoh, 1973; Šušić & Kovačević, 1973; Szymczak, 1987; Ookawa, 2004; Fuchs et al , 2006; Martinez‐Gonzalez et al , 2008; Dos Santos et al , 2009). In addition, most studies did not find a hippocampal theta rhythm during wakefulness in birds (Van Twyver & Allison, 1972; Sugihara & Gotoh, 1973; Dos Santos et al , 2009), apparently including flying pigeons navigating home (supplemental material in Vyssotski et al , 2009).…”

Section: Avian and Mammalian Sleepmentioning

confidence: 99%

See 1 more Smart Citation

Hippocampal memory consolidation during sleep: a comparison of mammals and birds

et al. 2010

View full text Add to dashboard Cite

The transition from wakefulness to sleep is marked by pronounced changes in brain activity. The brain rhythms that characterize the two main types of mammalian sleep, slow-wave sleep (SWS) and rapid eye movement (REM) sleep, are thought to be involved in the functions of sleep. In particular, recent theories suggest that the synchronous slow-oscillation of neocortical neuronal membrane potentials, the defining feature of SWS, is involved in processing information acquired during wakefulness. According to the Standard Model of memory consolidation, during wakefulness the hippocampus receives input from neocortical regions involved in the initial encoding of an experience and binds this information into a coherent memory trace that is then transferred to the neocortex during SWS where it is stored and integrated within preexisting memory traces. Evidence suggests that this process selectively involves direct connections from the hippocampus to the prefrontal cortex (PFC), a multimodal, high-order association region implicated in coordinating the storage and recall of remote memories in the neocortex. The slowoscillation is thought to orchestrate the transfer of information from the hippocampus by temporally coupling hippocampal sharp-wave/ripples (SWRs) and thalamocortical spindles. SWRs are synchronous bursts of hippocampal activity, during which waking neuronal firing patterns are reactivated in the hippocampus and neocortex in a coordinated manner. Thalamocortical spindles are brief 7-14 Hz oscillations that may facilitate the encoding of information reactivated during SWRs. By temporally coupling the readout of information from the hippocampus with conditions conducive to encoding in the neocortex, the slow-oscillation is thought to mediate the transfer of information from the hippocampus to the neocortex. Although several lines of evidence are consistent with this function for mammalian SWS, it is unclear whether SWS serves a similar function in birds, the only taxonomic group other than mammals to exhibit SWS and REM sleep. Based on our review of research on avian sleep, neuroanatomy, and memory, although involved in some forms of memory consolidation, avian sleep does not appear to be involved in transferring hippocampal memories to other brain regions. Despite exhibiting the slow-oscillation, SWRs and spindles have not been found in birds. Moreover, although birds independently evolved a brain region -the caudolateral nidopallium (NCL) -involved in performing high-order cognitive functions similar to those performed by the PFC, direct connections between the NCL and hippocampus have not been found in birds, and evidence for the transfer of information from the hippocampus to the NCL or other extra-hippocampal regions is lacking. Although based on the absence of evidence for various traits, collectively, these findings suggest that unlike mammalian SWS, avian SWS may not be involved in transferring memories from the hippocampus. Furthermore, it suggests that the slow-oscillation, the defining featur...

show abstract

Section: Avian and Mammalian Sleepmentioning

confidence: 99%

Section: Avian and Mammalian Sleepmentioning

confidence: 99%

Hippocampal memory consolidation during sleep: a comparison of mammals and birds

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In addition, the role of 5-HT 1A receptor signaling in behavioral outcome and cognitive functions is less investigated in the avian brain compared with mammals. Only a few studies suggest a role for this receptor type in ingestive behavior, circadian rhythm, sleep (Tejada et al, 2011;Fuchs et al, 2006;Garau et al, 2006;Da Silva et al, 2007;Campanella et al, 2009;Dos Santos et al, 2009), and impulsive reactions (Wolff and Leander, 2000). It was demonstrated that 5-HT modulates executive function during working memory in pigeons (Karakuyu et al, 2007) and possibly plays a role in visual attention switching (Miceli et al, 1999(Miceli et al, , 2002 and ingestive behavior (Güntürkün et al, 1989).…”

mentioning

confidence: 99%

Serotonin 5-HT1A receptor binding sites in the brain of the pigeon (Columba livia)

et al. 2012

View full text Add to dashboard Cite

Serotonin (5-HT) is a modulatory neurotransmitter that is involved in a variety of physiological and behavioral functions. In mammals, dysfunction of the serotonergic system has been linked to various diseases such as depression, schizophrenia, Alzheimer's disease, and eating disorders (Müller et al., 2007;Michelsen et al., 2008;Remington, 2008;Terry et al., 2008;Akimova et al., 2009;Polter and Li, 2010). In addition, growing evidence found in many species indicates that 5-HT modulates learning and memory (Jacobs and Azmitia, 1992;Winsauer et al., 1996; Meneses, 1999;Clarke et al., 2004; Meneses and PerezGarcia, 2007;Müller et al., 2007;Bert et al., 2008;Gasbarri et al., 2008;González-Burgos and Feria-Velasco, 2008;Sitaraman et al., 2008;Sambeth et al., 2009;Bari et al., 2010).Serotonin binds to multiple receptors (Hoyer et al., 2002;Green, 2006), which are widely distributed throughout the brain (Chalmers and Watson, 1991;Baumgarten and Grozdanovic, 1995;Barnes and Sharp, 1999;Riad et al., 2000). One of the most prominent is the 5-HT 1A receptor, which was first cloned and described by Fargin et al. (1988). The 5-HT 1A receptor belongs to the G protein coupled receptor superfamily and binds to a Gi/o protein (Innis and Aghajanian, 1987;Polter and Li, 2010). It displays a high affinity for 5-HT and occurs both pre-and postsynaptically (Hall et al., 1985;van Wijngaarden et al., 1990;Riad et al., 2000). As somatodendritic autoreceptors, 5-HT 1A receptors modulate the activity of 5-HT neurons, whereas they modify neuronal activity in terminal areas as postsynaptic receptors (Müller et al., 2007).The distribution of 5-HT 1A receptors in the brain has been investigated by several methods in rodents, nonhuman primates, and humans. Thereby, a high correlation between receptor binding with [3H]-8-hydroxy-2-(di-n-propylamino)tetralin ([ 3 H]-8-OH-DPAT) and 5-HT 1A mRNA densities has been shown (Chalmers and Watson, 1991;Pompeiano et al., 1992). High 5-HT 1A receptor densities were detected in the dorsal and median raphe nuclei and in areas of the limbic system such as the hippocampus, the lateral septum, the amygdala, as well as the entorhinal and cingulate cortices Zilles et al., 1985Zilles et al., , 2000Palacios et al., 1990;Yilmazer-Hanke et al., 2003). Moderate binding was detected in the olfactory bulb, the thalamus, hypothalamus, and several brain stem nuclei as well as neocortical areas. Low levels, or no binding, were reported in the basal ganglia and cerebellum (Gozlan et al., 1983;Marcinkiewicz et al., 1984;Zilles et al., 1985Zilles et al., , 2000Hall et al., 1997;Vergé et al., 1986;Albert et al., 1990;Palacios et al., 1990;Pompeiano et al., 1992;Khawaja, 1995; Kia et al., 1996a,b;Farde et al., 1997;Raurich et al., 1999;Hume et al., 2001;Maeda et al., 2001;Geyer et al., 2005;Palchaudhuri and Flügge, 2005;Eickhoff et al., 2007;Topic et al., 2007). 5-HT 1A receptors play a role in executive functions, anxiety related behavior, learning and reinforcement, feeding behavior, and locomotor activity (Zilles et al., 2...

show abstract

The role of serotonin in modulating common waxbill behaviour

Saldanha

Silva

Maximino

et al. 2023

Behav Ecol Sociobiol

View full text Add to dashboard Cite

Serotonin or 5-hydroxytryptamine (5-HT) is a monoaminergic neurotransmitter that is known to influence behaviour in various animal species. Its actions, however, are complex and not well-understood yet. Here, we tested whether and how two 5-HT receptor agonists and a 5-HT receptor antagonist influence behaviour in common waxbills (Estrilda astrild), focusing on aggression, movement and feeding. We applied acute administration of either 8-OH-DPAT (a 5-HT1A receptor agonist), fluoxetine (a selective serotonin reuptake inhibitor; SSRI) or WAY 100,635 (a 5-HT1A receptor antagonist), and then quantified behaviour in the context of competition for food. Waxbills treated with the SSRI fluoxetine showed an overall decrease of aggressive behaviour, activity and feeding, while we found no significant effects of treatment with the other serotonergic enhancer (8-OH-DPAT) or with the antagonist WAY 100,635. Since both 8-OH-DPAT and WAY 100,635 act mainly on 5-HT1A receptor pathways, while fluoxetine more generally affects 5-HT pathways, our results suggest that receptors other than 5-HT1A are important for serotonergic modulation of waxbill behaviour. Significance statement The serotonergic system is of interest for current behavioural research due to its influence on a range of behaviours, including aggression, affiliative behaviour, feeding and locomotion in various species. There are, however, numerous discrepancies regarding the behavioural effects of serotonin across studies. We used acute pharmacological manipulations of the serotonergic system in common waxbills, using two serotonin enhancers (8-OH-DPAT and fluoxetine) and a serotonin blocker (WAY 100,635). Behavioural effects of these pharmacological manipulations on aggressiveness, movement and feeding, during tests of competition over food, indicated an anxiogenic-like effect of fluoxetine, but not of 8-OH-DPAT and WAY 100,635. This suggests a distinct role for different serotonergic pathways on waxbill behaviour.

show abstract

Behavioural and electroencephalographic effects of systemic injections of 8-OH-DPAT in the pigeon (Columba livia)

Cited by 10 publications

References 79 publications

Hippocampal memory consolidation during sleep: a comparison of mammals and birds

Hippocampal memory consolidation during sleep: a comparison of mammals and birds

Serotonin 5-HT1A receptor binding sites in the brain of the pigeon (Columba livia)

The role of serotonin in modulating common waxbill behaviour

Contact Info

Product

Resources

About