Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings

Léonard, Carol; Laird, Laura; Burianová, Hana; Graham, Simon J.; Grady, Cheryl L.; Simić, Tijana; Rochon, Elizabeth

doi:10.1080/02687038.2014.971099

Cited by 25 publications

(12 citation statements)

References 42 publications

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“…of a word they cannot name, guided by the use of a chart. We and others have shown that PCA treatment improves naming performance in patients who suffer from chronic non-fluent or fluent aphasia ( 7 – 9 ) following a left hemisphere stroke. Improved naming after standard PCA treatment has been associated with neural activation changes in left hemisphere areas (e.g., supramarginal gyrus, left inferior frontal gyrus) and to a lesser extent, in right hemisphere areas (e.g., precuneus) ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 94%

Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity

et al. 2018

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Despite the growing evidence regarding the importance of intensity and dose in aphasia therapy, few well-controlled studies contrasting the effects of intensive and non-intensive treatment have been conducted to date. Phonological components analysis (PCA) treatment for anomia has been associated with improvements in some patients with chronic aphasia; however, the effect of treatment intensity has not yet been studied with PCA. Thus, the aim of the present study was to identify the effect of intensity on neural processing associated with word retrieval abilities after PCA treatment. We used functional magnetic resonance imaging to examine therapy-induced changes in activation during an overt naming task in two patients who suffered from a stroke in the left middle cerebral artery territory. P1 received intensive PCA treatment whereas P2 received the standard, non-intensive, PCA treatment. Behavioral results indicate that both standard and intensive conditions yielded improved naming performance with treated nouns, but the changes were only significant for the patient who received the intensive treatment. The improvements were found to be long lasting as both patients maintained improved naming at 2-months follow-ups. The associated neuroimaging data indicate that the two treatment conditions were associated with different neural activation changes. The patient who received the standard PCA showed significant increase in activation with treatment in the right anterior cingulate, as well as extensive areas in bilateral posterior and lateral cortices. By contrast, the patient who received intensive PCA showed more decreases in activation following the treatment. Unexpectedly, this patient showed subcortical increase in activation, specifically in the right caudate nucleus. We speculate that the recruitment of the caudate nucleus and the anterior cingulate in these patients reflects the need to suppress errors to improve naming. Thus, both short-term intensive and standard, non-intensive, PCA treatment can improve word retrieval in chronic aphasia, but neuroimaging data suggest that improved naming is associated with different neural activation patterns in the two treatment conditions.

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Section: Introductionmentioning

confidence: 94%

Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity

et al. 2018

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“…Preliminary neuroimaging data further indicate that the activation of cognitive functions, as in making an active choice, is important for successful treatment of anomia. In a study with "choice" or "no choice" conditions, all five participants demonstrated treatment effects, but only the participant from the "choice" condition showed a change in neural activation [23].…”

Section: Introductionmentioning

confidence: 99%

Naming of Objects and Actions after Treatment with Phonological Components Analysis in Aphasia

Kristensson¹,

Saldert²

2018

Clin Arch Commun Disord

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To explore the effects of intensive treatment with phonological components analysis on naming of both objects and actions. Methods: Phonological components analysis (PCA) was used to treat two individuals with moderate or severe aphasia after stroke. A single case study design with chronological time series analysis was employed to explore the effects of treatment for a total of up to 20 hours comprising the naming of self-chosen objects and actions. Changes in confrontation naming ability were assessed repeatedly. In addition, generalisation of training effects was examined in connected speech in a picture description task as well as in ratings of functional communication skills as perceived by the participants and their next of kin. Results: An increase in correctly produced words for treated items with some generalisation to untreated items was demonstrated post-treatment in a participant with moderate mixed fluent aphasia and mostly phonological errors. Number of words and degree of informativeness in the picture description task also increased. Results remained at a 10-week follow-up. A participant with severe conduction aphasia and mainly semantic errors in the pre-training assessment also demonstrated a small increase in correct confrontation naming post-treatment. Some aspects of functional communication skills were rated slightly higher, but both participants perceived the negative impact of the aphasia to be greater post-treatment. Conclusions: Phonological component analysis may be used in training of both objects and actions. However, aphasia severity and underlying deficits most likely influence the results and further research is warranted to explore the training effects.

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“…The reciprocal activation of phonological and semantic representations during naming therapy [74] might explain the fact that both semantic-and phonological-focused therapies have been found to improve naming abilities in many patients with aphasia [70,[75][76][77][78][79][80]. Such generalization was also found in our group's work [10,81]. Our specific hypotheses were as follows:…”

Section: Introductionmentioning

confidence: 57%

“…A complete presentation of the treatment results is available in the original papers [10,81]. To summarize, all treated patients demonstrated significantly improved naming of treated words post-treatment, and these gains were maintained at a follow-up assessment administered four weeks post-treatment.…”

Section: Behavioral Resultsmentioning

confidence: 96%

“…Approval for the secondary analysis of these data was obtained from the Research Ethics Board at Baycrest Centre, Toronto, Canada. Participants were part of previous studies investigating the efficacy of language treatment [65] and its neural correlates [10,81]. For consistency with the previous studies, we kept the original labels of the individual participants.…”

Section: Methodsmentioning

confidence: 99%

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Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy

et al. 2021

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Changes in brain connectivity during language therapy were examined among participants with aphasia (PWA), aiming to shed light on neural reorganization in the language network. Four PWA with anomia following left hemisphere stroke and eight healthy controls (HC) participated in the study. Two fMRI scans were administered to all participants with a 3.5-month interval. The fMRI scans included phonological and semantic tasks, each consisting of linguistic and perceptual matching conditions. Between the two fMRI scans, PWA underwent Phonological Components Analysis treatment. Changes in effective connectivity during the treatment were examined within right hemisphere (RH) architecture. The results illustrate that following the treatment, the averaged connectivity of PWA across all perceptual and linguistic conditions in both tasks increased resemblance to HC, reflecting the normalization of neural processes associated with silent object name retrieval. In contrast, connections that were specifically enhanced by the phonological condition in PWA decreased in their resemblance to HC, reflecting emerging compensatory reorganization in RH connectivity to support phonological processing. These findings suggest that both normalization and compensation play a role in neural language reorganization at the chronic stage, occurring simultaneously in the same brain.

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Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings

Cited by 25 publications

References 42 publications

Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity

Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity

Naming of Objects and Actions after Treatment with Phonological Components Analysis in Aphasia

Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy

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