Behavioural testing of standard inbred and 5HT1B knockout mice: implications of absent corpus callosum

Wahłsten, Douglas; Crabbe, John Jr; Dudek, Bruce C.

doi:10.1016/s0166-4328(01)00283-2

Cited by 30 publications

(22 citation statements)

References 36 publications

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“…For example, strain PL/J had an average brain weight of 0.506 g in the present study and 0.516 g in the Roderick study but 0.433 g in the Williams data (www.mbl.org), whereas the three studies found similar brain weights for C57BL/6J (0.495 g here, 0.489 for Roderick, and 0.482 for Williams). Previous data on brain size of eight strains from our laboratories [24] are very similar to the present data for the four strains included in both studies, whereas the former study with three laboratories found a significant main effect of laboratory but no significant interaction between strain and laboratory.…”

Section: Discussionsupporting

confidence: 88%

Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum

2003

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A morphometric survey of brain size and forebrain commissures of 21 inbred mouse strains from the Jackson Laboratory was done with animals tested in two laboratories as part of the Mouse Phenome Project. Strain BTBR T / + tf/tf was found to have 100% total absence of the corpus callosum as well as severe reduction of the hippocampal commissure in almost every animal, the most severe commissure defect observed to date in any commercially available mouse strain. The strain 129S1/SvImJ had a milder defect with incomplete penetrance.Crosses of BTBR mice with inbred strains BALB/cWah1, 129P1/ReJ, and the recombinant strain 9XCA/Wah having a severe commissure defect supported a two-locus model of the genetic defect in these strains. Brain size varied greatly among strains but for any one strain was almost identical in mice housed for 5 weeks in the two laboratories. Sex differences in brain weight and forebrain commissure sizes were not statistically significant. Theme: Disorders of the nervous system Topic: Genetic models

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Section: Discussionsupporting

confidence: 88%

Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum

2003

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“…Only one BALB/cWah1 mouse showed an abnormally small HC, whereas the HC was severely deficient in every 9XCA/Wah animal, including two in which there were almost no HC axons crossing the midline. There was a wide range of size of the CC in BALB/cWah1 mice, but this extreme size variation within BALB/cWah1 was not significantly related to fear conditioning (data not shown), which is consistent with the literature on behavioral sparing in CC agenesis (Schmidt et al, 1991;Bulman-Fleming et al, 1992;Wahlsten et al, 2001). As such, the focus of our analysis was on the difference between strains that arose from grossly different sizes of the HC.…”

Section: Commissural Anatomysupporting

confidence: 87%

“…This developmental variability within a genetically homogeneous strain provides a well controlled experiment of nature to assess the behavioral effects of an absent CC. Surprisingly, hereditary absence of the CC has little or no impact on a wide range of mouse behaviors (Schmidt et al, 1991;Bulman-Fleming et al, 1992;Wahlsten et al, 2001).…”

Section: Abstract: Hippocampal Commissure; Memory; Learning; Ltp; Fementioning

confidence: 99%

Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure

Schimanski¹,

Wahłsten

Nguyen

2002

J. Neurosci.

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The hippocampus is critical for forming new long-term memories, but the contributions of the hippocampal commissure (HC) to memory function and hippocampal synaptic plasticity are unclear. To shed light on this issue, we characterized behavioral memory and hippocampal synaptic plasticity in two inbred mouse strains. BALB/cWah1 mice display a range of corpus callosal defects and an intact HC, whereas 9XCA/Wah mice exhibit a complete absence of corpus callosum and a greatly reduced HC. No differences between strains were found in long-term potentiation (LTP) within two synaptic pathways in hippocampal slices. However, paired-pulse facilitation was deficient in area CA1 of slices from 9XCA/Wah, and it was rescued by decreasing extracellular [Ca 2ϩ ], suggesting that presynaptic calcium dynamics may be altered in this strain. In addition, contextual fear extinction was impaired in 9XCA/Wah mice, but performance on cued fear extinction and on 24 hr memory tests for cued and contextual fear conditioning were not significantly different between strains. Thus, an intact HC is critical for normal extinction of contextual fear. Intact interhemispheric connectivity is not required for acquisition or expression of cued and contextual fear conditioning. LTP was normal in slices from mice that lacked an intact HC, and this was correlated with normal performance on fear conditioning tests. In contrast, impaired short-term synaptic plasticity was correlated with defective contextual memory extinction in mice lacking an intact HC. Thus, the HC in mice is vital for particular aspects of memory function and for short-term synaptic modification in specific hippocampal circuits. Key words: hippocampal commissure; memory; learning; LTP; fear conditioning; extinction; agenesis; mouse strains; synaptic plasticityThe classic case study of H.M., a patient with surgical transection of the medial temporal lobes, demonstrated that the hippocampus is critical for the formation of new declarative memories (Scoville and Milner, 1957). Studies of human commissurotomy patients indicate that the main interhemispheric communication pathway between hippocampi, the hippocampal commissure (HC), is important for normal memory function. Indeed, patients with a transected HC show greater recognition memory deficits than those with an intact HC (Phelps et al., 1991). Patients with transection of both the corpus callosum (CC) and the HC also showed poor memory performance (Zaidel and Sperry, 1974). These findings indicate that an intact CC and HC are required for normal memory function.In two common inbred mouse strains, BALB/c and 129, agenesis of the CC occurs in Ͻ50% of these mice, whereas the remainder appear to have normal forebrain commissures (see Fig.

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“…Subjects were 24-month-old congenic mice (having primarily a C57BL/6J background; n = 16 females, n = 14 males), raised and group-housed in the Laboratory Animal Care Facility at The University at Albany [12,93].…”

Section: Subjects and Housingmentioning

confidence: 99%

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

2005

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Although 17β-Estradiol (E 2 ) improves cognitive performance of aged female mice, its mnemonic effects when administered post-training to aged male mice have not been examined. E 2 (10 µg, SC) or oil vehicle was administered to intact, 24-month-old female or male congenic (primarily C57BL/6 background) mice immediately after training in the inhibitory avoidance or water maze tasks. Following behavioral testing, effects of 1 or 24 h of E 2 exposure on hippocampal levels of E 2 and brain-derived neurotrophic factor (BDNF) were examined. Female and male mice administered E 2 showed significantly better performance in the inhibitory avoidance task than did vehicle-administered mice. When tested 24 h after training, mice that received E 2 had significantly longer latencies to cross-over to the shock-associated side of the chamber than did vehicleadministered mice. Female or male mice administered E 2 showed significantly better performance in the reference memory aspect of the spatial water maze task. When tested 30 min after training, mice administered E 2 had shorter latencies to, and spent longer swimming in, the quadrant that the hidden platform had previously been located in. E 2 administration produced physiological levels of E 2 in the hippocampus 1 and 24 h after E 2 . BDNF levels in the hippocampus were decreased following 1 h of E 2 exposure compared to vehicle. These findings suggest that E 2 to female and male mice may overcome age-related deficits in reference memory in an emotional or spatial learning task.

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Behavioural testing of standard inbred and 5HT1B knockout mice: implications of absent corpus callosum

Cited by 30 publications

References 36 publications

Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum

Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum

Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

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