Behçet Disease Associated With Myelodysplastic Syndrome

Lin, Yi‐Chun; Liang, Toong-Hua; Chang, Hsiao-Ning; Lin, Jeong‐Shi; Lin, Hsiao-Yi

doi:10.1097/rhu.0b013e3181776bde

Cited by 40 publications

(27 citation statements)

References 29 publications

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“…Kimura et al [18], having analyzed 46 MDS patients, revealed that trisomy 8 was the risk factor causing the development of multiple ulcerative lesions in intestines and thrombosis in MDS patients. Later, this assumption was confirmed by other researchers as well [19][20][21][22].…”

Section: Discussionsupporting

confidence: 76%

Behçet’s disease and comorbidity: internal case reports and literature review

et al. 2015

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The aim of this study was to determine the clinical characteristics of two patients with malignancy related to Behçet's disease. We reviewed literary-reported cases of Behçet's disease related to myelodysplastic syndrome, neoplasm and leukemia. Our own observation included two cases of comorbid conditions of Behçet's disease. The first patient with Behçet's disease had been examined concurrent development of intestinal tumor. The second one was diagnosed to have chromic myeloleukemia. The malignant transformation of Behçet's disease patients, both solid and hematological, is rather rare. Further accumulation of relevant date and its analysis will allow to find out the relationship between malignant disease and chemotherapy in Behçet's disease.

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Section: Discussionsupporting

confidence: 76%

Behçet’s disease and comorbidity: internal case reports and literature review

et al. 2015

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“…Furthermore, the prevalence rate of trisomy 8 is as high as 73.7% in MDS patients with BD [13]. Previous reports revealed several clinical characteristics such as a low prevalence rate of eye lesions and a high prevalence rate of intestinal lesions in BD patients with MDS involving trisomy 8 [14].…”

Section: Discussionmentioning

confidence: 99%

Refractoriness of Intestinal Behçet's Disease with Myelodysplastic Syndrome Involving Trisomy 8 to Medical Therapies - Our Case Experience and Review of the Literature

et al. 2013

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Background/Aims: Gastrointestinal lesions of Behçet's disease (BD) are often refractory to medical therapy and sometimes result in serious comorbidities such as gastrointestinal perforation and massive bleeding. There are several reports of patients with BD comorbid with myelodysplastic syndrome (MDS) involving trisomy 8 that frequently have intestinal lesions refractory to conventional medical therapy. Little is known about the efficacy of infliximab (IFX) for these intestinal lesions. Methods: We present 2 cases of intestinal BD with MDS involving trisomy 8 who did not respond to IFX, and review previous reports of BD with MDS involving trisomy 8 concerning their responsiveness to conventional medical therapy. Results: Among 31 previously reported cases that received medical treatment for BD, 19 (61.3%) showed temporary improvement of the BD symptoms, 9 (29.0%) deteriorated, and 3 (9.7%) showed no change. All of the 9 cases that showed deterioration had intestinal lesions. Our 2 cases failed to respond to IFX, resulting in a poor prognosis. Conclusions: IFX might not be effective for improving intestinal BD comorbid with MDS involving trisomy 8. Trisomy 8 is associated with the BD prognosis and refractoriness to conventional medical therapy.

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“…plications associated with BD. This knowledge does not seem to be well-known to dermatologists; therefore, we searched Pubmed for similar cases and found 31 reported cases (1,2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) (Table I). When the BD diagnostic criteria derived from the International Study Group (16) were applied to these 31 cases, recurrent oral aphthae and recurrent genital aphthae were found in more than 70% of the cases; however, ocular lesions were only rarely detected.…”

Section: Discussionmentioning

confidence: 99%